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The decades-long quest to develop a HIV vaccine has been dealt another major blow, with the 'last true candidate in development' failing to prevent infections any better than a placebo in late-stage clinical trials. The multinational Mosaico study, which began in 2019 and involved more than 3,900 volunteers, was investigating a four-shot HIV vaccine for cisgender men and transgender people who have sex with cisgender men and/or transgender people. As the US National Institute of Allergy and Infectious Diseases (NIAID) reported last week, the trial was stopped after a planned data review by the study's independent data and safety monitoring...

U.S. regulators on Thursday strictly limited who can receive Johnson & Johnson’s Covid-19 vaccine due to a rare but serious risk of blood clots. The Food and Drug Administration said the shot should only be given to adults who cannot receive a different vaccine or specifically request J&J’s vaccine. U.S. authorities for months have recommended that Americans starting their Covid-19 vaccinations use the Pfizer or Moderna shots instead. FDA officials said in a statement that they decided to restrict J&J’s vaccine after taking another look at data on the risk of life-threatening blood clots within two week of vaccination.

The Food and Drug Administration said the shot should only be given to adults who cannot receive a different vaccine or specifically request J&J's vaccine. U.S. authorities for months have recommended that Americans starting their COVID-19 vaccinations use the Pfizer or Moderna shots instead. FDA officials said in a statement that they decided to restrict J&J's vaccine after taking another look at data on the risk of life-threatening blood clots within two weeks of vaccination. J&J's vaccine was initially considered an important tool in fighting the pandemic because it required only one shot. But the single-dose option proved less effective...

Drugmaker Johnson & Johnson has halted production of its single-dose COVID-19 vaccine, according to a New York Times report. The pharmaceutical company last year quietly shut down production at a plant in Leiden, Netherlands, which was the only facility where usable doses of the vaccine were manufactured, catching some of its customers off guard, the report states. Johnson & Johnson has instead been using the plant to work on an experimental and potentially more profitable drug that could protect against an unrelated respiratory virus, according to the report.

@Breaking911 BREAKING: US health advisers recommend Pfizer or Moderna COVID-19 vaccines over J&J shot because of rare but serious blood clot side effect - AP

The wife of California Governor Gavin Newsom took to social media to defend her husband and call out 'haters without a life' who criticized Newsom's 12-day disappearance from public view in a since-deleted tweet. -snip- Newsom was last seen in public on October 27, receiving a COVID-19 booster shot in Oakland. He said it was painless and then flexed in celebration, urging others to get boosters as well.

LOS ANGELES -- Jennifer Siebel Newsom, the wife of Gov. Gavin Newsom, took to Twitter late Sunday to post, then delete a message urging people to "stop hating" while her husband has been out of the public eye since canceling plans to attend last month's climate summit in Scotland, according to a screenshot.......When the initial announcement was made Oct. 29, his office said Newsom planned to participate virtually in the United Nations climate summit. But he did not. His last public appearance was Oct. 27, when he received a coronavirus booster shot.

California Governor Gavin Newsom’s last public appearance was October 27th, when he received a coronavirus booster shot. Then, only two days later on October 29th, citing “family obligations,” Gov. Gavin Newsom abruptly cancelled his much anticipated trip to Scotland to attend the 2021 United Nations Climate Change Conference, the Globe reported. An aid made the surprise announcement. It’s been 10 days since Gov. Newsom has been seen by the public – unusual for the governor who did daily Coronavirus updates for nearly 18 months on end – and unusual for him to cancel such an important international event where he...

California Governor Gavin Newsom has disappeared from public view for 10 days and abruptly canceled plans to attend the COP26 climate summit in Scotland over unexplained 'family obligations.' Newsom was last seen in public on October 27, receiving a COVID-19 booster shot in Oakland. He said it was painless and then flexed in celebration, urging others to get boosters as well. Two days later, his office issued a statement citing unspecified family obligations, abruptly cancelling his plans to attend the global climate conference

Anew study conducted in one county in Minnesota has found an increased likelihood that citizens who received the Johnson & Johnson's COVID-19 vaccine were more likely to develop blood clots. The study by the Mayo Clinic found that recipients of the Johnson & Johnson vaccine, officially designated "Janssen," in Olmsted County, Minnesota, were about 3.7 times more likely to develop a certain variety of cerebral blood clots. Case numbers taken from February 28 to May 7, 2021, were compared to pre-pandemic levels of the blood clots from January 1, 2001, through December 31, 2015. Census data from 2020 showed that...

People who received Johnson & Johnson's COVID-19 vaccine have higher antibody levels if their booster shot is from Pfizer-BioNTech or Moderna, a new report suggests. The National Institutes of Health (NIH) has allegedly collected data showing that mixing-and-matching is more protective than getting two doses from the New Brunswick, New Jersey-based company, a person who has seen the data told Axios. NIH officials plan to present the findings during a meeting of the U.S. Food and Drug Administration's (FDA) vaccine advisory committee on Friday. It comes as J&J has asked the FDA to approve a shot of its own single-dose...

Food and Drug Administration scientists found potential benefit to a second dose of the Johnson & Johnson coronavirus vaccine in a data review that was released Wednesday and that depended heavily on the company’s analysis, suggesting a booster of that shot was perhaps more warranted than additional doses of other coronavirus inoculations. From the dawn of the vaccine campaign, many experts said they believed the one-shot Johnson & Johnson regimen would ultimately require a second shot, and the documents pave the way for a panel of experts who advise the FDA to discuss Friday the timing, necessity and safety of...

A woman from King County, Washington, who was in her late 30’s, has died from a rare blood-clotting syndrome after receiving Johnson & Johnson vaccine on September 7, according to a statement by Public Health – Seattle & King County. The woman, whose identity was not disclosed, received her vaccination on August 26, 2021. After 11 days of getting the vaccine, she died on September 7 with thrombosis with thrombocytopenia syndrome (TTS). The CDC verified that the woman indeed died from the vaccine and confirmed the diagnosis. The Washington State Department of Health released a statement regarding the recent death...

A King County woman has died from a blood clot after she got the Johnson & Johnson vaccine. The Washington State Department of Health (WSDH) confirmed she is the first blood clot death in the state after getting the Johnson & Johnson vaccine. “Sadly, this is the first such death in Washington State,’ Secretary of Health Umair A. Shah said. “We send our deepest condolences to her family and loved ones. Losing a loved one at any time is a tragic and difficult and pain that’s become all too familiar in the last year and a half of this pandemic.”...

The European Medicines Agency (EMA), the European Union's drug regulator, on Friday found a possible link between Johnson & Johnson's COVID-19 vaccine and rare cases of blood clotting in deep veins. During a Pharmacovigilance Risk Assessment Committee meeting, the agency said it found a possible link between venous thromboembolism (VTE) and the J&J vaccine. "VTE is a condition in which a blood clot forms in a deep vein, usually in a leg, arm or groin, and may travel to the lungs causing a blockage of the blood supply, with possible life-threatening consequences," the agency wrote in its meeting highlights. It...

"The Janssen COVID-19 Vaccine’s Local Reactions, Systemic Reactions, Adverse Events, and Serious Adverse Events" "Fever was more common in participants 18-59 years (12.8%) compared to those ≥60 years (3.1%). The majority of systemic reactions were mild or moderate in severity. The most common grade 3 reactions were fatigue and myalgia." "Among vaccine recipients aged 18-59 years, 26.4% reported using antipyretic or analgesic medications, compared to 6.0% of placebo recipients. Among vaccine recipients aged ≥60 years, 9.8% reported using antipyretic or analgesic medications, compared to 5.1% of placebo recipients." "Reports of embolic and thrombotic events had a slight numerical imbalance with...

The White House announced Friday that Dr. Anthony Fauci, medical advisor to President Joe Biden, said he expects Americans who received the one-dose J&J vaccine against COVID-19 also will be recommended for a booster shot. Federal health officials have said it’s likely that those who received the Johnson & Johnson (J&J) vaccine will need a booster as well. They are still analyzing the data on that vaccine. More guidance for Johnson & Johnson recipients is expected in the coming weeks.

KEY POINTS * Johnson & Johnson's vaccine won't capture nearly as much market share as Pfizer and Moderna this year. * The company's vaccine has been at a disadvantage due to a perceived lower efficacy rate. * Its effectiveness against the delta variant could lead to an increase in demand. Johnson & Johnson's (NYSE:JNJ) COVID-19 vaccine has had some challenges this year. From production issues to some disquieting reports of blood clots possibly being linked to the vaccine, it hasn't been the success the company was likely hoping it would be at this stage. Vaccines from Pfizer (NYSE:PFE) and Moderna...

A continuation from the spring “Which Vaccine to Get” thread. Almost half a year has passed since. Discussion of the three Covid vaccines currently available in the USA — Comparisons. Contrasts. Pros. Cons. First hand experiences, scientific insights, etc... The current vaccines available on the market are: 1) Pfizer/BioNTech (mRNA) 2 doses 2) Moderna (mRNA) 2 doses 3) Johnson & Johnson (DNA adenovirus vector) 1 dose 4) Boosters of mRNA

Johnson & Johnson's COVID-19 has had positive results in South Africa, the co-head of a trial, Glenda Gray, told reporters Friday. A research study conducted from mid-February to May with upwards of 470,000 health workers showed positive results in those inoculated, and the country’s health regulator approved the single-shot J&J vaccine in Apri. It is being used in addition to Pfizer's. The study showed 91% to 96.2% protection against death, Gray said, and 67% efficacy against infection when the beta coronavirus dominated and 71% when the delta variant did. As of Thursday, more than 8.3 million people had been vaccinated...