Free Republic

An enzyme called PGK1 has an unexpectedly critical role in the production of chemical energy in brain cells, according to a preclinical study. The investigators found that boosting its activity may help the brain resist the energy deficits that can lead to Parkinson's disease. The study presented evidence that PGK1 is a "rate-limiting" enzyme in energy production in the output-signaling branches, or axons, of the dopamine neurons that are affected in Parkinson's disease. This means that even a modest boost to PGK1 activity can have an outsized effect on restoring the neuronal energy supply in low-fuel conditions—and the researchers showed...

Paul Harrell instructed his brother to post his goodbye video when he died. His brother posted it today.

The Biden-Harris administration said Tuesday that it opposed Prime Minister Benjamin Netanyahu’s plan to hold onto the Gaza-Egypt border — known as the Philadelphi Corridor — to ensure weapons cannot be smuggled into Gaza. State Department spokesperson Matthew Miller said in a briefing with reporters on Tuesday that the U.S. opposed any long-term Israeli presence in Gaza. He also said that Israel had agreed to a U.S. “bridging” proposal last month that would have required the Israel Defense Forces (IDF) to withdraw from “densely populated areas,” which Miller said “includes the Philadelphi Corridor.”

WHEELING, WV (WTRF) – West Virginia Governor Jim Justice is among a group of 24 Republican governors who joined together to write a letter to President Joe Biden to state their united opposition to two proposals currently under negotiation that would grant the World Health Organization (WHO) what they call “unprecedented and unconstitutional” powers in the United States. The governors state that “if adopted, these agreements would seek to elevate the WHO from an advisory body to a global authority in public health. ...they are concerned the most recent draft of the “Pandemic Treaty,” which would allow for the WHO...

When former President Donald Trump held a campaign event at Arlington National Cemetery last week, 1st Lt. Jimmy McCain says he viewed it as a “violation.” The youngest son of the late Sen. John McCain had already been moving away from the Republican Party — just weeks ago, he changed his voter registration to Democrat and plans to vote for Kamala Harris in November, he told CNN in an exclusive interview this week. But he is speaking out now for the first time about Trump because of the former president’s conduct at the hallowed ground where several generations of McCain’s...

The country’s strongman president, Nicolás Maduro, made the curious announcement that this year’s festivities would begin in October on Monday, in the midst of a political bleak midwinter for his crisis-stricken land. “It’s September and it already feels like Christmas. So this year – as a way of paying tribute to you and thanking you – I’m going to decree that Christmas be brought forward to 1 October,” Maduro proclaimed during one of his frequent TV appearances. Venezuela’s authoritarian leader, who is facing what experts call the greatest political challenge of his turbulent 11-year rule, promised all Venezuelans a Christmas...

New research shows that a treatment plan based on a novel combination of low doses of three anti-hypertensive drugs in a single pill—known as GMRx2—was superior to a high-quality standard care treatment plan at lowering blood pressure in patients with uncontrolled hypertension. Results of the 'deliVERy of Optimal blood pressure coNtrol in afrICA (VERONICA)-Nigeria' trial, were presented today. The GMRx2 treatment plan involved a once daily pill containing telmisartan, amlodipine and indapamide at a quarter, half or standard doses. The standard care treatment plan began with monotherapy, followed by dual and triple combination therapy, and was typical of hypertension guidelines...

Hundreds of homes in the coastal Los Angeles suburb of Rancho Palos Verdes have lost power due to a slow landslide that has resulted in several houses being deemed unsafe for occupancy. NBC Los Angeles reported: Power was shut off to an additional 105 homes Monday night due to accelerating landslides in a Rancho Palos Verdes neighborhood. The latest round of shutoffs occurred at 7 p.m. Monday in the Seaview area of the Los Angeles County seaside community overlooking the Pacific. On Sunday, power was shut off in 140 homes in the Portuguese Bend area. Those residents also remain under...

This is (I hope) going to be a short narrative, but I felt this needs to be shared for hopefully the benefit of others here. I am leaving Twitter/X. I'm done with it, and it's for reasons you might not think. Let me say that I'm glad Elon Musk bought it and opened it up to be used as it's supposed to be used. I'm glad the many folks that were once banned under the old regime were able to have their accounts restored. And I'm glad it is being used as a means to expose the lies, hatred, bigotry...

PlayStation will be taking its new Firewalk-developed live services game “Concord” offline this Friday and issuing refunds to players just two weeks after its Aug. 23 launch. The team-based first-person shooter game is reported to have drawn a historically small audience during its initial availability across PlayStation 5 and PC, with third-party PC-based gaming data website SteamDB showing 30 current in-game players at the time of publication on Tuesday. At the peak in its short history, “Concord” had 697 concurrent players, drastically low for a PlayStation new release, and ranked toward the bottom of PlayStation’s weekly sales charts. In “Concord,”...

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On Tuesday’s broadcast of the Fox News Channel’s “Fox & Friends,” Israel’s Ambassador to the U.N. Danny Danon responded to President Joe Biden criticizing Israeli Prime Minister Benjamin Netanyahu by alleging Netanyahu hasn’t done enough to get a ceasefire by stating that “we expect our ally, the U.S., to say, very clearly, Hamas is to be blamed for the fact we don’t have a deal today” in the wake of Hamas killing multiple Israeli hostages and an American hostage. Danon said, “[I]t’s very simple, the blame is on Hamas, period. You cannot blame Netanyahu or the Israelis. Hamas always say[s]...

While Reagan, Sean McNamara's new movie, has received largely negative reviews from critics, it has beaten box office expectations during its first weekend, ranking No. 4 on the charts. The Ronald Reagan biopic, which depicts the life of the actor and politician, stars Dennis Quaid as the 40th president and Penelope Ann Miller as Nancy Reagan. The film is loosely based on The Crusader: Ronald Reagan and the Fall of Communism, a 2006 book written by Paul Kengor. Reagan tells the story of its subject from his childhood through his acting career—with a focus on his struggle against communists in...

Fool's Ball Week 1!!!!!!!!!! Your home for all things Fool's Ball! In Memoriam Danny Lee (BENDER2)

Binyamin Netanyahu has said that Sir Keir Starmer’s decision to suspend some arms sales to Israel is “shameful” and will “only embolden Hamas”. The government has suspended 30 of Britain’s 350 arms export licences with Israel amid concerns that the weapons could be used against civilians in Gaza in breach of international law. The decision covers components for fighter aircraft, helicopters and drones, as well as equipment for hitting targets on the ground. “This shameful decision will not change Israel’s determination to defeat Hamas, a genocidal terrorist organisation that savagely murdered 1,200 people on October 7, including 14 British citizens....

After 50 years, the Thomas Merton Center will cease operations but has pledged to continue its work through its community-run thrift store in Garfield. The center, named for the 20th century American trappist monk, activist and writer, announced it will close due to budget constraints.

There are presumably 5 more bombers at Engels AFB that could potentially join in. Meanwhile, about a dozen "Geran" drones entered Ukrainian airspace through the north.

Seven Republican-led states on Tuesday filed a lawsuit to challenge the Biden administration's latest student debt forgiveness plan, saying the U.S. Department of Education was taking steps to start canceling loans as soon as this week. The lawsuit came less than a week after the U.S. Supreme Court rejected the Biden administration's bid to revive a different student debt relief plan that was designed to lower monthly payments for millions of borrowers and speed up loan forgiveness for some.

A businesswoman who styled herself as the “Queen of Trash” has gone on trial in Sweden accused of illegally dumping mountains of waste, in the country's biggest ever environmental crime case. Bella Nilsson is one of 11 people charged with “aggravated environmental crime”. She was chief executive of waste management company NMT Think Pink, which is accused of dumping or burying 200,000 tonnes of waste in 21 locations between 2015 and 2020. Lawyers for Ms Nilsson who is now called Fariba Vancor, and another former chief executive Leif-Ivan Karlsson say they deny any wrongdoing. Entering Attunda district court north of...

What is the sphere of influence – that is, the region in which the United States has a legitimate right to assert itself on the world scene, and demand respect for our borders, our shores, our people and our goods? When our nation was in the process of being founded in the 1770s and 1780s, our Founding Fathers would have identified our thirteen colonies, and stopped there. We weren’t interested in other nations’ petty squabbles and they had no business being involved in ours, so we believed. That position was soon to change. We hadn’t realized that our global shipping...