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Mayo Clinic researchers have linked the T cell dysfunction seen in rheumatoid arthritis with a metabolic deficiency. In "helper" T cells from patients with rheumatoid arthritis, low levels of a specific amino acid lead to cellular miscommunication, but supplying it may provide a new therapeutic strategy for autoimmune disease. Rheumatoid arthritis is an autoimmune disorder characterized by chronic inflammation, including high levels of a cytokine called tumor necrosis factor, or TNF. This protein is used to recruit immune system resources and can cause cell death (necrosis). Based on data collected over more than 20 years of work, Dr. Weyand's team...

The Toronto District School Board (TDSB) is not allowing its students to attend a book club meeting featuring author Nadia Murad Murad's book details how she escaped the Islamic State, where she was ripped from her home and sold into sexual slavery aged just 14 years old The superintendent Helen Fisher said Muslim students would be offended and the book 'promotes Islamophobia' Book club founder and TDSB parent Tanya Lee said the book 'has nothing to do with ordinary Muslims. (TDSB) should be aware of the difference' The Board later issued an apology but still won't let the students attend...

Moderna MRNA, -4.36% CEO Stéphane Bancel has left no doubt whether he’s taking a glass half-full or half-empty approach to the emergence of the new omicron coronavirus variant.He told the Financial Times there’s no world where current vaccines are as effective as they have been against the delta variant. And he suggested the drop-off could be significant.“I think it’s going to be a material drop. I just don’t know how much because we need to wait for the data. But all the scientists I’ve talked to . . . are like, ‘This is not going to be good’.”The interview put...

TV doctor Mehmet Oz formally announced his campaign for Senate in Pennsylvania on Tuesday, resetting the GOP field in a critical race with a focus on the coronavirus pandemic. “We have not managed our crises as effectively as past generations,” Oz wrote in a Washington Examiner op-ed. “During the pandemic, I learned that when you mix politics and medicine, you get politics instead of solutions. That’s why I am running for the U.S. Senate: to help fix the problems and to help us heal.” Oz didn’t specify in his column that he was running for the Republican nomination, but after...

Rep. Nancy Mace (R-S.C.) shot back at Rep. Marjorie Taylor Greene (R-Ga.) on Tuesday after Greene called her "trash," responding by using emojis to call her fellow first-term Republican congresswoman "batsh*t crazy." Mace was responding to Green's Tuesday morning tweet that accused her of being a "RINO," or Republican in name only, after Mace condemned Rep. Lauren Boebert (R-Colo.) for making anti-Muslim remarks about Rep. Ilhan Omar (D-Minn.). Mace "is the trash in the GOP Conference," Greene tweeted. "Never attacked by Democrats or RINO’s (same thing) because she is not conservative, she’s pro-abort. Mace you can back up off of...

Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases. The cells in your body are constantly renewing themselves, with older cells aging and dying as new ones are being born. But sometimes that process goes awry. Occasionally damaged cells linger. Called senescent cells, they hang around, acting as a bad influence on other cells nearby. Their bad influence changes how the neighboring cells handle sugars or proteins and so causes metabolic problems. Type 2 diabetes is the most common metabolic disease in...

Oakland Mayor Libby Schaaf on Monday revealed plans to reverse cuts to the city's police department and seek to hire more officers amid a spike in violence and homicides. The decision makes Oakland the latest city to bolster its support for law enforcement after several cities that committed to defunding the police in the wake of George Floyd's murder in 2020 experienced a considerable rise in violent crime. ... From New York City to Los Angeles - in cities that had some of the largest Black Lives Matter protests, and some with an extensive history of police brutality - police...

During remarks about the new Xi variant of Wuhan coronavirus at the White House Monday, President Joe Biden was asked to define a "new normal" for the American people. Biden responded by saying the "new normal" is endless vaccination and booster shots. "Mr. President, is this the new normal that Americans should expect: anticipating future potential variants?" a reporter asked. "To answer your first question first, the answer is: I expect this not to be the new normal. I expect the new normal to be everyone ends up getting vaccinated and the booster shot so we reduce the number of...

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Meghan McCain slammed CNN anchor Chris Cuomo in a Tuesday op-ed for The Daily Mail, calling him "unfit" for the job in the wake of allegations that he worked to defend his brother, former New York Gov. Andrew Cuomo (D), during his sexual harassment scandal. In the opinion piece, McCain questions why CNN hasn't already fired Cuomo, insinuating that CNN President Jeff Zucker may be attempting to save his own reputation. "Seriously, what does Chris Cuomo know about Jeff Zucker that is so compromising that Jeff doesn't want the American public to know?" she asks. "At this point, I can't...

hough the two countries already cooperate militarily, a recent document defines their relationship more concretely. Russia and China’s defense ministers inked a roadmap for closer future ties, moving closer to a de facto military alliance. During a video conference call, Defense Minister Sergei Shoigu and Wei Fenghe, the Chinese Defense Minister, signed the cooperation document “simultaneously” according to TASS, the Russian state-owned news agency. Russia’s Defense Ministry explained that Russia and China have “expressed a shared interest in stepping up strategic military exercises and joint patrols. During the call, Shoigu explained that both his country and China have been partners...

#Disrupt Texts and its co-thinkers are dedicated enemies of enlightenment and education. Students, teachers and serious academics should treat them with derision, challenge them and expose their ignorance.

Steven Spielberg’s adaptation of the beloved musical “West Side Story” finally began to screen for awards voters over the weekend ahead of its Christmas Day release. First reactions are pouring out as the film’s official premiere at the El Capitan Theatre in Los Angeles gets underway. Early reactions are offering praise for Spielberg’s direction and high marks for Rachel Zegler as Maria in her film debut. The musical premiered mere days after the death of Stephen Sondheim (who wrote the lyrics for the original production, with a book by Arthur Laurents and score by Leonard Bernstein) at the age of...

The UK’s minimum gap for Covid-19 booster jabs will be halved from six months to three, after the UK Government accepted advice from the Joint Committee on Vaccination and Immunisations to speed up the programme.Criminally, the Government also accepted the JCVI’s advice to offer all children over the age of 12 a second dose of the Pfizer vaccine, twelve weeks following the first dose, despite knowing the risk of myocarditis and pericarditis is much higher following the second dose.The UK Government and its scientific advisers claim that the reason for cutting the time people must wait to get a booster...

A common medication used to treat reflux, heart burn and ulcers could lessen the effectiveness of lung cancer immunotherapy drugs. The study investigated the impact of proton pump inhibitors (PPIs) on patients undergoing treatment for non-small-cell lung cancer, the most common type of lung cancer, accounting for 85 percent of cases. Patients received either chemotherapy or were treated with a combination of chemotherapy and atezolizumab, an immune checkpoint inhibitor drug, designed to boost the immune system into killing cancer cells. The researchers found PPI use was associated with worse survival in patients with advanced cancer treated with atezolizumab plus chemotherapy,...

Data available from Public Health Scotland shows that cases of ovarian cancer in 2021 are much higher than the 2017-2019 average, and deaths of new-born babies have reached the upper warning threshold indicating factors beyond random variation may have contributed to the deaths.With nearly 40,000 menstrual disorders being reported as adverse reactions to the Covid-19 vaccines, scientists warning of potential issues with the formulation of the Covid-19 injections leading to infertility, real-world data showing the rate of miscarriage following Covid-19 vaccination is as high as 82%, and a confidential study showing the Covid-19 vaccine accumulates in the ovaries over time,...

In a story TrialSite has been following, a patient in suburban Chicago has been discharged from a hospital after receiving ivermectin. The patient’s daughter, Dr. Man Kwan Ng, filed a lawsuit against Edward Hospital to have ivermectin administered to her father. Illinois Judge Paul Fullerton ordered the hospital to administer the drug saying, “the benefits could outweigh the risks.” Apparently, the judge was correct in this case.Over the Thanksgiving weekend 71-year-old Sun Ng walked out of the hospital. He was given a regimen of 15 daily shots of ivermectin starting on November 8th. The drug was administered by Dr. Alan...

LONDON -- Consumer prices across the 19 countries that use the euro currency are rising at a record rate as a result of a huge spike in energy costs this year, official figures showed Tuesday. Eurostat, the European Union's statistics agency, said the eurozone's annual inflation rate hit 4.9% in November, the highest since recordkeeping began in 1997 and up from 4.1% in October, the previous high mark. Across the eurozone, inflation is running at multiyear highs, including in Germany, Europe's largest economy, where the annual rate has hit 6%. Even that is below the 6.2% recorded at last count...

Miss USA has been running since 1952 and has traditionally been a celebration of thin, mostly white, able-bodied women — but this year’s pageant was noted for the diversity of its contestants. Organizers of the proudly progressive contest have been actively pushing to make it more inclusive, according to NBC. The event was dubbed “Pageantry Reimagined,” and featured just nine blonde contestants.

Senate Majority Leader Charles Schumer (D-N.Y.) is planning to bring President Biden's social and climate spending bill to the floor as soon as the week of Dec. 13, a source familiar confirmed to The Hill. Schumer's plan is to bring the bill, known as Build Back Better, to the Senate floor once Democrats finish their conversations with the parliamentarian, who provides guidance on what can be included in a bill passed through budget reconciliation. "As soon as the necessary technical and procedural work with the Senate parliamentarian has been completed... the Senate will take up this legislation," Schumer told reporters...