Posted on 11/30/2021 12:52:41 PM PST by ConservativeMind
A common medication used to treat reflux, heart burn and ulcers could lessen the effectiveness of lung cancer immunotherapy drugs.
The study investigated the impact of proton pump inhibitors (PPIs) on patients undergoing treatment for non-small-cell lung cancer, the most common type of lung cancer, accounting for 85 percent of cases.
Patients received either chemotherapy or were treated with a combination of chemotherapy and atezolizumab, an immune checkpoint inhibitor drug, designed to boost the immune system into killing cancer cells.
The researchers found PPI use was associated with worse survival in patients with advanced cancer treated with atezolizumab plus chemotherapy, but not in those that received chemotherapy alone, with the study showing PPI use was linked to a significant decrease in the benefit of the immune therapy treatment.
"Stomach issues and reflux are common in cancer patients so the use of antacids and PPIs is common." says Dr. Hopkins.
"Of concern is that the medication is often overused, or used inappropriately, as it is seen to cause little harm, however our research could indicate a need to change this approach."
PPIs treat a number of stomach issues by reducing acid production in the wall of the stomach, with types including esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole.
Recent studies have shown the medication can cause significant gut microbiota changes, which could lead to its impact on cancer immunotherapy.
"Immune checkpoint inhibitor (ICI) drugs help the immune system by switching on T-cells, allowing them to kill or control cancerous tumors, but the gut microbiota also plays an important role in regulating our body and its immune function," says Dr. Hopkins.
"When this gut microbiota is impacted it can stop the ability of ICIs to activate the immune system, meaning the drugs simply won't work as well to fight off the cancer."
(Excerpt) Read more at medicalxpress.com ...
I’m sure the vaccine isn’t implicated at all.
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