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Major depressive disorder (MDD) affects approximately 280 million people globally and is one of the leading causes of disability. One in every three people suffering from MDD also has to deal with treatment-resistant depression (TRD), a condition where patients do not respond to at least two antidepressant trials. Esketamine nasal spray, a rapid-acting anti-depressant, is known to be effective against TRD when administered alongside antidepressants like selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI). A study retrospectively compared the effectiveness of both the combinations in treating TRD and found that esketamine plus SNRI showed significantly better overall...

Blue laser vaporization alleviates lower urinary tract symptoms while preserving sexual function in patients undergoing benign prostatic hyperplasia (BPH) surgery, according to a study. Zun-Jie Hu and colleagues assessed the impact of 450-nm blue laser vaporization on sexual function in 67 patients (median age, 65 years) undergoing BPH surgery and followed for three months. The researchers found that blue laser vaporization significantly improved International Prostate Symptom Score, quality of life, and International Consultation on Incontinence Modular Questionnaire for Male Lower Urinary Tract Symptoms (ICIQ-MLUTS) scores. Blue laser vaporization was also significantly associated with a reduction in postvoid residual volume. There...

Two people were killed an six more were injured during the mass shooting that took place Thursday at Florida State University. As I described here, the shooter was stopped in the act and sent to the hospital by police. It sounds like he's going to survive. He was later identified as Phoenix Ikner, a 20-year-old student at FSU. His mother was also identified as a local sheriff's deputy. Ikner used one of her handguns in the attack. However, today we've got a lot more information about Ikner and his history and what it shows is a lot of family problems,...

The acting commissioner of the Internal Revenue Service (IRS) was replaced Friday, only three days after assuming the role, as his appointment triggered a power struggle between Treasury Secretary Scott Bessent and Elon Musk of the Department of Government Efficiency, the New York Times reported. Gary Shapley was replaced after Bessent complained to President Donald Trump that Musk circumvented Bessent’s office to secure the position for Shapley, the NYT reported. The outlet cited people who said they were familiar with the situation. Shapley was a longstanding IRS agent who accused the Biden administration’s Department of Justice of dragging out its...

The deep state is in a state of chaos after Pete Hegseth fired three Department of Defense aides who were allegedly involved in the leaking of classified government information earlier this year, along with the departure of Hegseth’s chief of staff from his role following an extended period of turmoil within the agency. For context, on April 18, 2025, Hegseth terminated three Defense aides — a senior adviser named Dan Caldwell, Deputy Chief of Staff Darin Selnick, and Chief of Staff to the Deputy Secretary of Defense Colin Carroll —and removed Chief of Staff Joe Kasper from his position. All...

According to the Migration Policy Institute and ACLU, approximately 75% of deportations under the Obama administration (2009–2017) were nonjudicial removals, meaning they bypassed immigration court hearings and judicial oversight. In FY 2012 alone, 313,000 nonjudicial removals occurred, compared to 1,400 in 1995. These removals often involved "expedited removal" or "administrative removal," where Department of Homeland Security (DHS) agents, such as Border Patrol or ICE officers, made decisions without involving an immigration judge. Did you hear one word about this from the media?

America's oldest serving astronaut Don Pettit has returned to Earth on his 70th birthday. The Soyuz MS-26 space capsule carrying Pettit and his Russian crewmates Alexey Ovchinin and Ivan Vagner made a parachute-assisted landing in Kazakhstan's steppe at 06:20 local time (01:20 GMT) on Sunday. They spent 220 days on board the International Space Station (ISS), orbiting the Earth 3,520 times, the US space agency Nasa said. For Pettit - who has now spent a total of 590 days in space - it was his fourth mission. Still, he is not the oldest person to fly in orbit - that...

During this week’s broadcast of FNC’s “Sunday Morrning Futures,” Sen. Mike Lee (R-UT) offered an optimistic take on the Trump administration’s challenge to the country’s existing birthright citizenship policy currently being considered by the Supreme Court. “Look, Jason, this is a fascinating case,” he said. “It’s a close case. It can be won. No one knows the outcome for sure. But one thing that’s important for everyone to keep in mind, this case is not about whether birthright citizenship exists, nor does it undermine the 14th Amendment’s birthright citizenship promise. This is, rather, about what the contours of birthright citizenship...

BETHLEHEM, Conn. (WFSB/Gray News) – A father in Connecticut was arrested after he said he shot a bear in self-defense to protect his family. The shooting happened at Todd Topicz’s home in August. He said that the bear entered the home through the garage, where his two kids were at the time. “He [the bear] walked right into the garage with people in there. He didn’t care. So, who knows what would’ve happened next time,” Topicz said.

Researchers at the University of Jyväskylä have for the first time isolated a giant virus in Finland, Jyvaskylavirus, revealing that these large amoeba‑infecting viruses are more widespread in northern soils and waters than previously thought. (Artist’s concept.) Credit: SciTechDaily.com ************************************************************************ Finland’s first giant virus, Jyvaskylavirus, shows these viruses are more widespread than thought and play key roles in ecosystems. For the first time in Finland, researchers at the University of Jyväskylä’s Nanoscience Center have isolated a giant virus, which they have named Jyvaskylavirus. This discovery suggests that giant viruses may be more widespread in northern regions than previously believed. It...

Saturday evening, I published three posts on A.A.R.P. v. Trump. Around midnight eastern time, Justice Alito issued his dissent, which was joined only by Justice Thomas. The dissent begins: "Shortly after midnight yesterday, the Court hastily and prematurely granted unprecedented emergency relief." He is correct. Justice Alito lists seven bullets which demonstrates why this order was problematic. The first bullet argues that it is unclear the Court had jurisdiction: It is not clear that the Court had jurisdiction. The All Writs Act does not provide an independent grant of jurisdiction. See 28 U. S. C. §1651(a) (permitting writs "necessary or...

It would be pointless to try and introduce Gene Simmons in a comprehensive way. He’s done too much, lived too long, and reinvented himself too many times to be summed up in a line or two. And so, I’ll simply tell you that my conversation with this legendary rock star led me to conclude that he is, among a great many other things, a patriot and a Momma’s boy. Although, not necessarily in that order. I suspect you’ll reach a similar conclusion.

Welcome to the PRAYER REQUESTS thread. This daily thread is a listing of prayer requests that have been posted by Freepers to the main forum who wish to have continued prayer. Hopefully this thread will remind us to continually pray for our fellow Freepers’ cares and needs. GOD hears and answers our prayers.

Democratic National Committee Vice Chair David Hogg said Sunday on ABC’s “This Week” that the Trump administration was showing it did “not care about the rule of law.” Partial transcript as follows: FORMER RNC CHAIR REINCE PRIEBUS: They’ve got no — well, he said they’ve got no message. They’ve got no movement. They’ve got no leader. I mean, it doesn’t get any worse than that. I mean, you’re defending Harvard. You’re traveling to El Salvador for MS-13 gang members. But here’s the point. KARL: Alleged. PRIEBUS: You’re taking $20 million, if I’m looking at someone, my vice chair, the RNC...

For the freedom you enjoyed yesterday... Thank the Veterans who served in The United States Armed Forces. Looking forward to tomorrow's freedom? Support The United States Armed Forces Today! ~ Hall of Heroes ~ Robert F. Stryker Info from here. Robert F. Stryker (November 9, 1944-November 7, 1967) was a United States Army soldier received the Medal of Honor for his actions during the Vietnam War. He is buried in Pine Hill Cemetery Throop, New York. The Army Stryker vehicle is named in his and PFC Stuart S. Stryker's honor. Rank and organization: Specialist Four, U.S. Army, Company C,...

"What did Trump just say about Jesus that made some Christians absolutely lose their minds?"

Secretary of Defense Pete Hegseth shared detailed plans about a military operation against the Houthis in Yemen on a second Signal group chat that included his wife, lawyer and brother, three people familiar with the chat told CNN.The revelation comes as some of Hegseth’s closest advisers have begun sounding the alarm about the secretary’s judgment, including his former press secretary, John Ullyot, and three former senior officials Hegseth fired last week — his top adviser Dan Caldwell, deputy chief of staff Darin Selnick, and Colin Carroll, who served as chief of staff to the deputy secretary of defense.

Mel brooks, Dom DeLuise, and Marty Feldman witness Bernadette Peters' nightclub act...Ba ba - Loooo... Scene from Silent Movie (1976, Mel Brooks)Silent Movie was co-written, directed by and starring Mel Brooks, released by 20th Century Fox in the summer of 1976. The ensemble cast includes Dom DeLuise, Marty Feldman, Bernadette Peters, and Sid Caesar, with cameos by Anne Bancroft, Liza Minnelli, Burt Reynolds, James Caan, Marcel Marceau, and Paul Newman as themselves, and character cameos by Harry Ritz of the Ritz Brothers, Charlie Callas, and Henny Youngman. The film was produced in the manner of an early-20th-century silent film, with...

The most popular Easter service in this capital of alternative living occurs not in church but on the sloping lawns of Dolores Park, where thousands show up in their Sunday best — which at the annual Hunky Jesus Contest can mean steampunk bonnets, a life-size Peep suit or, for those competing, elaborate (and usually scanty) Jesus and Mary costumes.

If you haven’t been to a comic convention or a celebrity event, you might not know how expensive celebrity autographs can be. Some think famous actors shouldn’t charge fans for autographs or photos, as they already earn a lot. But perhaps they just want to make extra money while they are still famous. Check out their prices, some of them just may surprise you! Mark Hamill Charging $195 for autographs and photos, the Star Wars star generated significant revenue during his 2016 appearance at Fan Expo Canada. While the exact number of autographs is unknown, his earnings were substantial enough...