Cranial surgery is tricky business, even under 21st-century conditions (think aseptic environment, specialized surgical instruments and copious amounts of pain medication both during and afterward). However, evidence shows that healers in Peru practiced trepanation — a surgical procedure that involves removing a section of the cranial vault using a hand drill or a scraping tool — more than 1,000 years ago to treat a variety of ailments, from head injuries to heartsickness. And they did so without the benefit of the aforementioned medical advances... According to Kurin, trepanations first appeared in the south-central Andean highlands during the Early Intermediate Period...