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In a nutshell * Steroid injections were associated with faster arthritis progression compared to no treatment or hyaluronic acid injections * Hyaluronic acid injections showed signs of slowing disease progression while still providing pain relief * Both treatments reduced pain, but only steroid shots were linked to concerning structural changes on MRI scans ============================================================ SAN FRANCISCO — Getting a cortisone shot for knee arthritis might provide quick pain relief, but new research reveals a troubling association: those steroid injections may be linked to faster joint damage over time. A surprising study found that patients who received corticosteroid injections showed more...

A clinical trial led by Monash University found that the common diabetes drug metformin significantly reduced knee pain in people with osteoarthritis and overweight or obesity, potentially delaying the need for knee replacements. Over six months, participants taking metformin experienced greater pain relief than those on placebo, offering a promising, low-cost alternative treatment. ======================================================================== Metformin may reduce knee pain in overweight patients with osteoarthritis, offering a low-cost alternative to early knee replacement surgery, according to a Monash University trial. A widely used diabetes medication may help relieve knee osteoarthritis (OA) pain in people who are overweight or obese, potentially delaying...

A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, research has found. Metformin, which is commonly prescribed to treat type 2 diabetes, reduced knee arthritis pain over six months in a clinical trial. The research was performed as a community-based study using telehealth. Some of the 107 participants with pain from knee osteoarthritis, who had a mean age of 60, took up to 2,000 mg of metformin daily for six months. Others took the placebo. None had diabetes. Knee pain was measured on a 0–100...

Amazon is planning a $1 million donation to president-elect Donald Trump’s inaugural fund, as founder Jeff Bezos and other tech leaders shore up ties with the incoming administration. The Wall Street Journal reports that the donation is being prepared as Jeff Bezos, Amazon’s executive chairman, is slated to visit Donald Trump next week at his private Mar-a-Lago club in Palm Beach, Florida, according to people familiar with the matter. Bezos and the company decided on the contribution earlier this week and communicated it to Trump’s team. “Bezos is donating through Amazon,” according to a person close to Bezos.

Kamala Harris was frequently absent for California Medical Assistance Commission meetings, even though she was appointed to the position by her boyfriend at the time and then-Assembly Speaker Willie Brown. Harris and Brown dated for about a year when she was a 29 year old lawyer for the Alameda District Attorney's office and he was the powerful speaker who ran for mayor of San Francisco at the age of 60. Brown appointed Harris to the CMAC position in 1994, drawing some criticism for impropriety despite Brown’s willingness to publicly flaunt accusations of political patronage. Harris had already served six months...

Bullet entered from behind just above the calf and exits forward right side of knee. Smooth folded skin entry wound. Who shot Crooks from behind? I haven't heard it mentioned or explained in any of the analysis. Just an observation.

A single injection of a new, off-the-shelf stem cell therapy for knee osteoarthritis significantly improved pain and function for up to 12 months in 75% of participants involved in a clinical trial. The treatment also has the potential to halt the disease’s progression. In 2020, 7.6% of the global population had the painful degenerative condition osteoarthritis, an increase of 132.2% in total cases since 1990. It’s expected that by 2050, cases will have increased by 74.9% for knee, 48.6% for hand, and 78.6% for hip osteoarthritis. Current treatment includes pain relief, usually with non-steroidal anti-inflammatory drugs (NSAIDs), exercise as tolerated,...

It’s the cycle of life. Lifelong bicyclers may live longer, have stronger immune systems and are less likely to experience knee pain or osteoarthritis, than people who don’t ride bikes. Although previous studies have already shown several benefits of cycling, new research now shows that people who cycle regularly have significantly less chance of developing osteoarthritis by the age of 65, according to NPR. The study, which was published last month in Medicine & Science in Sports & Exercise, surveyed 2,600 people with an average age of 64 about their lifetime exercise habits. All of the participants were at an...

Former populist Alexandria Ocasio-Cortez (D-NY) bent the knee to the Democrat establishment by surrendering her first dues payment to the Democratic Congressional Campaign Committee (DCCC). House campaign committees require election cycle dues from lawmakers. The amounts vary depending on party status. Lawmakers accumulate power by raising and dispersing funds to committees and colleagues. The parties award members for the donations with better committee assignments and favorable legislation treatment.

Vladimir Putin once again appeared to be unable to control a twitchy leg during his lengthy interview with US right-wing journalist Tucker Carlson earlier this week. The Russian president spent half an hour of the sit-down chat on an almost uninterrupted ramble covering 1,200 years of Eastern European history. But some viewers were distracted by his apparent need to physically push down his knee to prevent his leg from moving around. It’s been an odd habit of Putin’s for a while – stretching back at least as far as September 2022, when the appendage started twitching during a speech in...

For patients undergoing total knee arthroplasty (TKA), treatment with diosmin—a flavonoid supplement derived from citrus fruits—reduced swelling of the knee and leg and some measures of associated pain can be achieved, reports a clinical trial. Swelling is a common problem in patients undergoing TKA, and one that contributes to pain and patient dissatisfaction. Currently, there are no effective medication choices to reduce swelling after TKA. Diosmin—often in combination with a related flavonoid called hesperidin—has been used to reduce swelling of the limbs in patients with venous disorders. The exploratory study included 330 patients undergoing TKA at 13 university-affiliated hospitals. Patients...

A newly appointed Home Office minister sparked fury on the Tory right today after pictures were unearthed showing her taking the knee during the Black Lives Matter protests. Laura Farris, the MP for Newbury, said how it was important MPs and other public figures 'are there with the community showing their support' in the fight against racism in 2020. She attended the event in the Berkshire town in June 2020 in a mask during the Covid pandemic, less than a month after the murder of George Floyd by police in the US city of Minneapolis sparked worldwide protests. But her...

President Biden wanted to wrap up his appearance with the NBA Champion Golden State Warriors on Tuesday by taking a knee with Vice President Kamala Harris. But she refused and chuckled: 'I'm not doing that' – leaving the 80-year-old on the front of the stage, on his own, in an awkward end to the photo-op. The gesture from the president was met with laughter from the team and sounds of shock from the audience, including from his No. 2, who didn't want to join in on the kneeling position that became popular with athletes during Black Lives Matter protests. The...

Osteoarthritis is a degenerative joint disease that causes the cartilage in the joints to break down, leading to pain, stiffness, and difficulty moving. It is a common condition that often affects the hands, knees, hips, and spine. Risk factors for developing osteoarthritis include aging, obesity, and a history of joint injuries. Two recent studies have shown that corticosteroid injections, which are commonly used to treat the pain associated with knee osteoarthritis, may actually contribute to the progression of the disease. These findings were recently presented at the annual meeting of the Radiological Society of North America (RSNA). Osteoarthritis is a...

A decrease in body mass index (BMI) was associated with both a lower incidence of the structural defects of knee osteoarthritis and a lower likelihood that such defects would progress, or get worse. Researchers examined radiographic analyses of knees at baseline and at 4 to 5 years' follow up from adults with and without the structural defects of knee osteoarthritis at the start of the study. The team assessed 9,683 knees (from 5,774 individuals) in an 'incidence cohort' and 6,075 knees (from 3,988 individuals) in a 'progression cohort.' A 1-unit decrease in BMI corresponded to a 4.76% reduction in odds...

Injections of hyaluronic acid (known as viscosupplementation) to treat knee osteoarthritis make almost no difference to pain and might raise risk of adverse events, suggests research. Knee osteoarthritis is a chronic disease that involves inflammation and structural changes of the joints, resulting in joint pain and limitations to physical movement. It is a leading cause of disability among older people. National and international guidelines vary in their recommendations, but most advise against the use of viscosupplementation. In England, guidelines recommend against its use, but health care systems in other countries including the U.S. still offer it to patients. An international...

President Joe Biden bent down on one knee for a photo with Navy sailors after commissioning the USS Delaware submarine. The president and his wife First Lady Jill Biden appeared at the commissioning ceremony in Delaware on Saturday.

President Biden and first lady Jill Biden on Saturday participated at the 9/11 ceremony in Shanksville, Pennsylvania, commemorating the 20th anniversary of the 9/11 attacks. Today he looked lost again and hardly able to walk as he approached the site of the crash of flight 93. Then for some weird reason, Biden gets down on a knee. Video: (video uploaded on the site0 President Joe Biden commemorated the 20th anniversary of the Sept. 11 attacks on the United States on Saturday with visits to each of the sites where hijacked planes crashed in 2001, honoring the victims of the devastating...

Latasha Brown, co-founder of Black Voters Matter, said the president’s possible gesture was admirable, but “we cannot just have symbolic progress.” President Joe Biden got down on one knee in the East Room during the celebration of the 2021 WNBA champions Seattle Storm, on the eve of the vote on the John Lewis Voting Rights Act in the House and days before the anniversary of the March on Washington. While the WNBA has been at the forefront of professional basketball when it comes to issues of social justice and police reform, this is not the first time the president gotten...

It's a moral duty. https://youtu.be/ypTbsWPsSws