Posted on 07/29/2024 12:12:55 PM PDT by Red Badger
A single injection of a new, off-the-shelf stem cell therapy for knee osteoarthritis significantly improved pain and function for up to 12 months in 75% of participants involved in a clinical trial. The treatment also has the potential to halt the disease’s progression.
In 2020, 7.6% of the global population had the painful degenerative condition osteoarthritis, an increase of 132.2% in total cases since 1990. It’s expected that by 2050, cases will have increased by 74.9% for knee, 48.6% for hand, and 78.6% for hip osteoarthritis.
Current treatment includes pain relief, usually with non-steroidal anti-inflammatory drugs (NSAIDs), exercise as tolerated, and joint replacement surgery. No available treatment delays the progression of the condition, and long-term use of NSAIDs increases the risk of stomach ulcers, kidney failure, and stroke or heart attack. However, clinical trials of a new one-injection stem cell treatment for osteoarthritis, developed by the private Australian biotech company Magellan Stem Cells, have shown very promising results.
“Our research indicates that Magellan’s off-the-shelf donor stem cell treatment is safe and effective in improving joint function, reducing pain levels, and may have the potential to halt the progression of osteoarthritis,” said Associate Professor Julien Freitag, lead researcher and Magellan’s Executive Director and Chief Medical Officer.
MAG200 is a single injection of donor stem cells into the joint (an intra-articular injection). It’s considered an ‘off-the-shelf’ therapy because it uses donor, or allogeneic, stem cells rather than the patient’s own, the surgical harvesting of which is labor-intensive. Importantly, because the treatment uses mesenchymal stem cells – adult stem cells that can differentiate into other cell types – from adipose tissue or body fat, it doesn’t trigger an immune response.
(Excerpt) Read more at newatlas.com ...
Ping!...................
Off-the-shelf ?
7-11 has them.
If this had only come out sooner, I might not have had to have that painful knee replacement surgery last year. Ouch.
“Off-the-shelf ?”
It pays to read the article ...
My boss just had one replaced last week.
I think I’ll email him this article................🙄
“Off-the-shelf” is just a clinical term......you can’t run out and buy it at Walgreens. Lol!
Yes, it’s in the pharmacy between the Athlete’s foot creams and the heartburn pills...............
Pingaroony
Bump for reading later...
They work well as far as pain. I get the injections every two months, or so. I do not know if the cartilage is healed or not. I am sure losing 25 pounds has not hurt.
Not stem cells for me. I think mine is chicken or turkey. Not kidding.
.
It’ll be on the shelf next to the expanding crack sealer that you use to make a butt that can be used to stack cafeteria trays on.
I’m curious how you are doing now? My mother had a knee replacement in November and she isn’t doing well. It doesn’t feel any better than before she had the surgery. She has been very disciplined in her post-op therapy and has done everything her doctors have told her to no avail. She is at her wits end.
Don;t be a fat, carb feasting, non exercising slob and you can cut your risk of this kind of maladay. Look at the data, 80%+ of knee replacement are on morbidly obese.
It would be great if this was effective for finger joint OA.
People have been doing stem cell therapy on knees for a long time, a friend of mine had it done a few times over several years and said it helped him significantly for a while each time.
I guess the only difference with this study is the source of stem cells?
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