Free Republic

Josep Tabernero presented data at this week's American Society of Clinical Oncology's (ASCO) 20th Annual Gastrointestinal Cancers Symposium. This open-label controlled two-arm, phase III comparison study was designed to validate the efficacy and safety of the orally administered combination of trifluridine/tipiracil plus monoclonal antibody bevacizumab versus trifluridine/tipiracil alone in the third-line treatment of patients with refractory metastatic colorectal cancer (mCRC) who had progressed after two lines of prior therapy. Around 50% of colorectal cancer patients will ultimately develop metastasis, with a five- year survival rate of only 11%. The prognosis for patients with refractory disease remains poor, with median survival...

Obama's spokesperson refused on Tuesday to say whether the former president was searching his homes for classified documents, as The New York Times reported that prosecuting Donald Trump for mishandling files could be complicated by Joe Biden's own classified chaos. [cut] Biden said he had 'no regrets', yet five searches have now yielded documents - on Tuesday it emerged that Mike Pence, the former vice president, had found also classified documents at his own Indiana home. Obama's communications director, Hannah Hankins, was asked on Tuesday by Fox News whether he too was searching his homes. 'We have nothing for you...

On this day (Jan. 25) in 1978, Joy Division played their first live gig, a moment that is often credited with kicking off the post-punk era. The iconic, yet short-lived rock outfit – made up of frontman Ian Curtis, guitarist and keyboardist Bernard Sumner, bassist Peter Hook, and drummer Stephen Morris – premiered their unique blend of moody punk-tinged, synth rock at Pips Discotheque in Manchester, England. Back then, Pips was the place to be, a hub where the ever-shifting culture of late 1970s Britain was continually being shaped. “Inside there were different sub-cultures all coming together,” an article from...

A Vanderbilt math professor criticized the subject for being too "white" and "cisheteropatriarchal" in a lecture he presented at a major mathematician conference earlier this month. Luis Leyva, an assistant professor of mathematics at Vanderbilt Peabody College of Education and Human Development in Nashville, Tennessee, at the Joint Mathematics Meeting on January 4 delivered a lecture titled "Undergraduate Mathematics Education as a White, Cisheteropatriarchal Space and Opportunities for Structural Disruption to Advance Queer of Color Justice."

Thirteen crew members were rescued on Wednesday from a cargo ship that sank off southwestern Japan during fierce winter winds, with planes and ships, including private vessels, searching for the remaining nine. The vessel, the 6,651-tonne Hong Kong-registered “Jintian”, issued a distress call late on Tuesday, the Japan Coast Guard said. Media reported a person on the ship said it was listing and taking on water, and later reports said the 22 crew members – all Chinese or Myanmar nationals – had transferred to lifeboats. There was no immediate word on what caused the vessel, which was carrying lumber, to...

CLEVELAND – A Parkland, Florida, man pleaded guilty on Tuesday, Jan. 24, 2023, to devising a scheme that defrauded several companies involved in the sale of polymers, including one business in Northeast Ohio, and multiple logistic companies, causing losses of more than $4.1 million. According to court documents, from July 2013 to January 2020, Terrence Anderson, 66, devised a scheme to steal shipments of polymers from businesses involved in the sale of the chemicals. The scheme was achieved, in part, by fraudulently obtaining services from logistic companies involved in processing rail shipments. Court documents show that Anderson owned and operated...

The National Archives has missed the House Oversight Committee’s deadline to comply with requested documents related to President Joe Biden’s classified document scandal, according to the committee’s spokesperson. On January 10, the committee demanded the National Archives hand over records detailing the interactions between Biden’s attorneys and the Justice Department on or before January 24. “The National Archives has not produced the requested documents to the Committee at this time,” the committee spokesperson told reporters Tuesday. “Chairman Comer’s request still stands and anticipates moving forward with a transcribed interview with NARA’s general counsel soon.”

The man who gave the Marshall Tucker Band their name died at age 99 on Jan. 20. The Southern rock pioneers chose their moniker from a random discovery soon after they’d formed in 1972, as they confirmed in a social media post. “We are saddened to hear of the passing of someone very special to our hearts, for very obvious reasons,” the post read. “Our band’s namesake, Mr. Marshall Tucker, passed away peacefully yesterday morning at the age of 99. Though he was never a member of our band, we wouldn’t be here today without his historic name.” It continued:...

Conversion of St. Paul, Apostle–W (III) (Comm. of St. Peter, Apostle) January 25, 2023 Saul of Tarsus was full of hatred for Jesus and his disciples. From a bitter persecutor he became an ardent apostle and the irresistible preacher of the Gospel. *-*-*-*-*-*-*-*-*-* The great apostle PAUL, named Saul at his circumcision, was born at Tarsus, the capital of Silicia, and was by privilege a Roman citizen, to which quality a great distinction and several exemptions were granted by the laws of the empire. He was early instructed in the strict observance of the Mosaic law, and lived up to...

Is the Government protecting Ray Epps during the Proud Boys Trial and possibly MANIPULATING FOOTAGE to incriminate the Proud Boys? *See video never-before-seen video below from the 14,000 hours the Government is hiding! Please watch all the videos in this article for complete clarity.We have EVIDENCE to warrant an investigation into the matter! A protected source has released footage to the Gateway Pundit that was played in court during the Proud Boy’s trial. This video is “confidential” and part of the 14,000 hours of footage THEY DON’T WANT US TO SEE!!

clown, familiar comic character of pantomime and circus, known by distinctive makeup and costume, ludicrous antics, and buffoonery, whose purpose is to induce hearty laughter. The clown, unlike the traditional fool or court jester, usually performs a set routine characterized by broad, graphic humour, absurd situations, and vigorous physical action. The earliest ancestors of the clown flourished in ancient Greece—bald-headed, padded buffoons who performed as secondary figures in farces and mime, parodying the actions of more serious characters and sometimes pelting the spectators with nuts. The same clown appeared in the Roman mime, wearing a pointed hat and a motley...

VIDEO AT LINK................... Jan. 24 (UPI) -- A Maryland 9-year-old searching for shark teeth on a beach made her largest discovery to date -- a 15 million-year-old megalodon tooth. Molly Sampson was out searching for shark teeth on Calvert County Cliffs on Christmas Day when she found a megalodon tooth the size of her hand. "I couldn't believe it, it was so exciting," Sampson told WJLA-TV. "I usually find little ones, I never thought I would find a big one like that." Sampson took her discovery to the Calvert Marine Museum in Solomon's Island, where experts confirmed it was an...

Matt Gaetz joined Steve Bannon on the War Room to discuss the Deep State’s reaction to the unfolding Biden classified document scandal. Gaetz recalled how Americans, who saw the Russian Collusion sham for what it was, were branded conspiracy theorists.

Failed Texas gubernatorial candidate Beto O’Rourke has claimed that he returned a $1 million donation from disgraced former FTX CEO Sam Bankman-Fried; however, it appears that he did not return all of the money, according to a report. A spokesman for O’Rourke said in November that the campaign returned the “unsolicited” $1 million donation Bankman-Fried gave the Texas Democrat in October. An O’Rourke spokesman said that the refund was issued prior to FTX’s bankruptcy and the discovery of Bankman-Fried’s reportedly illegal business practices. However, the Washington Free Beacon found that the O’Rourke team did not return all of the money:

Pope discusses his health, his critics and future of papacyPope Francis says he hasn’t considered issuing norms to regulate future papal resignations and plans to continue for as long as he can as bishop of Rome, despite a wave of criticism from some top-ranking conservative cardinals and bishops about his papal priorities.In his first interview since the Dec. 31 death of retired Pope Benedict XVI, Francis addressed his critics, his health and the next phase of his pontificate, which marks its 10th anniversary in March without Benedict’s shadow in the background.Francis’ comments, delivered Tuesday at the Vatican hotel where he...

Russian President Vladimir Putin avoided commenting on Germany's landmark decision on Wednesday to supply tanks to Ukraine during a visit to Moscow State University, instead dispensing career advice to students and fielding questions on other topics. Putin, a fluent German speaker who served in the former East Germany as a KGB officer, spent more than an hour responding to students' questions on issues ranging from lost dogs to quantum technology, though the war in Ukraine also kept cropping up indirectly. Putin took a swipe at Western countries by suggesting some were using the Ukraine war as an excuse to "cancel"...

Dubya looked and didn't find, O refuses to answer, Trump declassified, had disputes, got raided, Brandon is stonewalling, pleading the 5th, hiding behind clown lady.

He’s been blacklisted. Anthony Loffredo, who calls himself the “black alien,” removed his ears, nostrils and even a few fingers; sharpened his teeth and dyed them purple; and covered his body in extreme tattoos. Now the Frenchman says he’s found one space where he can’t come in peace.

Fibrotic cancers such as gastric cancers are highly resistant to conventional therapies like immune checkpoint inhibitors. Cancer-associated fibroblasts (CAFs) are an important part of this resistance. Now, researchers have demonstrated that regorafenib and anti-PD-1 work synergistically to target CAFs, in turn modifying the cancer stroma and reducing fibrotic tumor growth. Gastric cancer (GC) is the third leading cause of death worldwide. Diffuse-types GCs (DGCs) are characterized by rapid progression. An important component of fibrotic cancer stroma is cancer-associated fibroblasts (CAFs), which are responsible for rapid GC progression and resistance to standard therapies. The interaction between platelet-derived growth factors (PDGFs) and...

Barack Obama, George W. Bush, and Bill Clinton are sidestepping the classified documents controversies embroiling their successors, with staffers saying the former presidents all turned over their materials to the National Archives and Records Administration years ago when they left office. "That process was conducted in 2008 and 2009, and all Presidential records – classified and unclassified – were turned over to the National Archives upon leaving the White House," said Freddy Ford, Bush's spokesperson, when asked what Bush is doing to assess whether he has any classified documents in his possession, in light of recent discoveries that President Joe...