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The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030. The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side...

I remember being a kid and seeing my grandmother without her dentures for the first time. It was a harrowing experience. Now my dad has dentures so, genetically speaking, I’m several decades out from needing some myself. However, it’s possible that modern medicine will solve the issue of lost teeth by then, thanks to a new drug that's about to enter human trials. The medicine quite literally regrows teeth and was developed by a team of Japanese researchers, as reported by New Atlas. The research has been led by Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital....

The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030. The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side...

Researchers in Japan are currently working on a medication that would allow people to grow a new set of teeth, with a clinical trial slated for July 2024.

Teeth from long-dead people and animals are divulging the history of modern-day pathogens.Ancient DNA extracted from the teeth of humans who lived long ago is yielding new information about pathogens past and present. In one of the latest studies, researchers uncovered and sequenced ancient herpes genomes for the first time, from the teeth of long-dead Europeans. The strain of herpes virus that causes lip sores in people today — called HSV-1 — was once thought to have emerged in Africa more than 50,000 years ago. But the new data, published in Science Advances on 27 July1, indicate that its origin...

In a new analysis of thousands of teeth from ancient skeletons buried at a site near Naples, Italy, archaeologists have discovered that people were using their mouths to help with their work -- occupations that likely involved processing hemp into string and fabric. We all use our teeth as tools -- to open bottles, hold pieces of paper, or even smoke a pipe. When we do this, we open ourselves up to the possibility of cracking our teeth but also create microscopic grooves and injuries to the enamel surface. Since teeth don't remodel like bones do, these tiny insults remain...

A new paper in Molecular Biology and Evolution, published by Oxford Univeristy Press, uncovers well-preserved microbiomes from two 4,000 year old teeth in a limestone cave in Ireland. These contained bacteria that cause gum disease, as well as the first high quality ancient genome from S. mutans, an oral bacterium that is one of the major causes of tooth decay.These discoveries allowed the researchers to assess the impact of past dietary changes on the oral microbiome across millennia, including major changes coinciding with the popularization of sugar and industrialization. The teeth, both derived from the same Bronze Age man, also...

Since the fourth millennium BCE, when urban civilizations first appeared in ancient Mesopotamia, humans have strived to achieve proper dental hygiene. Yet the nylon-bristled toothbrush we use today didn’t come along until the 1930s. For the thousands of years in between, people relied on rudimentary tools that evolved with scientific knowledge and technological advancements over time. Some of the earliest toothbrush predecessors date as far back as 3500 BCE. Here’s a look at how people kept their teeth clean before the modern toothbrush.AdvertisementChew Sticks and ToothpicksSometime around the year 3500 BCE, the ancient Babylonians (located near modern-day Iraq) created a...

November 21, 2022 Share Email 592205.jpg Credit: U.S. Military One of the keys to bringing home unidentified military remains, including POW/MIAs and the more than 81,500 soldiers unaccounted for in conflicts dating back to World War II, is using science to determine where home might be. University of Utah scientists are engaged in an effort, in support of the Defense POW/MIA Accounting Agency, to develop methods that can trace the geographic origin of remains, particularly teeth. Why teeth? Because everyone’s body, including their teeth, contains a record of where they’ve lived and traveled in the form of various stable isotopes...

Dental Detectives Reveal Diet of Ancient Human Ancestors Sean Markey for National Geographic News November 9, 2006 Paranthropus robustus, a dead-end branch of the early human family tree, has been described as a "chewing machine" that was mostly jaws and not much brains. While the label may still apply, pioneering dental detective work has revealed unexpected news about the species' dietary variety. Using lasers to vaporize tiny particles of tooth enamel, researchers in the United States and Great Britain analyzed the chemical makeup of 1.8-million-year-old fossil teeth from four individuals unearthed in the Swartkrans cave site in South Africa. Different...

...The results published in PNAS (Proceedings of the National Academy of Sciences) also suggest tooth decay was more prevalent in earlier societies than previously estimated. The results also suggest that the hunter-gatherer society studied may have developed a more sedentary lifestyle than previously thought, relying on nut harvesting. Dental disease was thought to have originated with the introduction of farming and changes in food processing around 10,000 years ago. A greater reliance on cultivated plant foods, rich in fermentable carbohydrates, resulted in rotting teeth.High level of decayNow, the analysis of 52 adult dentitions from hunter-gatherer skeletons found in a cave...

Hunter-gatherers had almost no malocclusion and dental crowding, and the condition first became common among the world's earliest farmers some 12,000 years ago in Southwest Asia... By analysing the lower jaws and teeth crown dimensions of 292 archaeological skeletons from the Levant, Anatolia and Europe, from between 28,000-6,000 years ago, an international team of scientists have discovered a clear separation between European hunter-gatherers, Near Eastern/Anatolian semi-sedentary hunter-gatherers and transitional farmers, and European farmers, based on the form and structure of their jawbones... In the case of hunter-gatherers, the scientists from University College Dublin, Israel Antiquity Authority, and the State University...

When tooth enamel forms, it incorporates elements from the local environment -- the food one eats, the water one drinks, the dust one breathes. When the researchers looked at remains from the ancient city of Harappa, located in what is known today as the Punjab Province of Pakistan, individuals' early molars told a very different story than their later ones, meaning they hadn't been born in the city where they were found... The text of the Indus Valley Civilization remains undeciphered, and known and excavated burial sites are rare. A new study, published in today's PLOS ONE, illuminates the lives...

In what Prof. Barkai describes as a "time capsule," the analysed calculus revealed three major findings: charcoal from indoor fires; evidence for the ingestion of essential plant-based dietary components; and fibers that might have been used to clean teeth or were remnants of raw materials. "Prof. Karen Hardy published outstanding research on the dental calculus of Neanderthals from El Sidron cave in Spain, but these dated back just 40,000-50,000 years—we are talking far earlier than this," said Prof. Barkai. "This is the first evidence that the world's first indoor BBQs had health-related consequences," said Prof. Barkai. "The people who lived...

DNA evidence lifted from the ancient bones and teeth of people who lived in Europe from the Late Pleistocene to the early Holocene -- spanning almost 30,000 years of European prehistory -- has offered some surprises, according to researchers who report their findings in the Cell Press journal Current Biology on Feb. 4, 2016. Perhaps most notably, the evidence shows a major shift in the population around 14,500 years ago, during a period of severe climatic instability... The researchers pieced this missing history together by reconstructing the mitochondrial genomes of 35 hunter-gatherer individuals who lived in Italy, Germany, Belgium, France,...

Scientists have found traces of rampant tooth decay in the teeth of people living almost 9,000 years ago in today's Poland. According to the researchers from the Cardinal Stefan Wyszynski University in Warsaw, the disease, which is also known as [cavities], could have been the result of consuming too much fruit and honey. Traditionally, it was thought that tooth decay became common only after man began to lead a sedentary lifestyle and use more processed cereal products. But, with farmers not appearing in Poland until about 7,000 years ago, the 9,000-year-old discovery has taken the scientists by surprise... Professor Jacek...

Protest in France has tapered off since the Yellow Vests mass demonstrations in late 2018 and early 2019 but this week a spirited nationwide protest by farmers emerged. Larg conglomerates and global businesses the target of farmers anger since their policies threaten the ability of French farmers to make a living... French political leader Florian Philippot ("Les Patriots") saying that deal with the South American countries: "will kill our agriculture"... As the protests spread to highways in the Paris area Friday Prime Minister Gabirel Attal appearing at a cattle farm. He announced measures including the cancellation of a planned tax...

People with both type 1 and type 2 diabetes are prone to tooth decay, and a new study from Rutgers may explain why: Reduced strength and durability of enamel and dentin, the hard substance under enamel that gives structure to teeth. Researchers induced type 1 diabetes in 35 mice and used a Vickers microhardness tester to compare their teeth with those of 35 healthy controls over 28 weeks. Although the two groups started with comparable teeth, enamel grew significantly softer in the diabetic mice after 12 weeks, and the gap continued to widen throughout the study. Significant differences in dentin...

Scientists in London develop pain-free filling that allows teeth to repair themselves without drilling or injections The tooth-rebuilding technique developed at King's College London does away with fillings and instead encourages teeth to repair themselves. Tooth decay is normally removed by drilling, after which the cavity is filled with a material such as amalgam or composite resin. The new treatment, called Electrically Accelerated and Enhanced Remineralisation (EAER), accelerates the natural movement of calcium and phosphate minerals into the damaged tooth. A two-step process first prepares the damaged area of enamel, then uses a tiny electric current to push minerals into...

The federal government is calling for lower levels of fluoride in drinking water, the first update since the 1960s. The new recommendation is for 0.7 milligrams of fluoride per liter of water, which replaces the previous range of 0.7 to 1.2 milligrams, according to the Health and Human Services Department on Monday. Americans have access to more fluoride through toothpaste and mouth rinses than when the recommendations were introduced in 1962, the agency said. Because Americans are using more fluoride, officials are worried about increases in cases of fluorosis, a condition that stains teeth exposed to too much fluoride. "The...