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Squamous cell carcinoma of the skin is a type of cancer that starts as a growth of cells on the skin. It starts in cells called squamous cells. The squamous cells make up the middle and outer layers of the skin. Squamous cell carcinoma is a common type of skin cancer. Squamous cell carcinoma of the skin is usually not life-threatening. But if it's not treated, squamous cell carcinoma of the skin can grow large or spread to other parts of the body. The growth of the cancer can cause serious complications. Most squamous cell carcinomas of the skin are...

The skin acts as the body's defense against external threats. However, as we age, the epidermis—the outermost layer of skin—gradually becomes thinner and loses its protective strength. To combat aging's impact on skin, numerous studies have emphasized the benefits of vitamin C (VC). Now, researchers have discovered VC helps thicken skin by directly activating genes that control skin cell growth and development. Their findings suggest that VC may restore skin function by reactivating genes essential for epidermal renewal. To investigate how VC affects skin regeneration, the team used human epidermal equivalents and applied VC at 1.0 and 0.1 mM—concentrations comparable...

WASHINGTON, D.C. — The leader of the free world was sporting a new look this morning, as witnesses noticed that President Donald Trump's skin had returned to normal human color just one day after HHS Secretary Robert F. Kennedy Jr. began phasing out artificial dyes. The president's hue marked a drastic change from the standard orange-tinted tone he had become known for, with experts speculating that RFK Jr.'s ban on synthetic dyes resulted in Trump's skin reverting back to a far more natural shade commonly associated with human beings. "He's a cleaner, far less-toxic Trump," said one White House...

In a nutshell * Compound K, a rare ginseng metabolite, fights skin aging through multiple pathways simultaneously — strengthening skin barrier, boosting collagen, and reducing inflammation * Unlike many anti-aging ingredients, Compound K can penetrate skin effectively and may activate longevity genes while improving cellular energy production * While laboratory results are promising, most research is still in early stages with limited human clinical trials to confirm effectiveness in commercial products ==================================================================================== GUANGZHOU, China — For thousands of years, ginseng has been treasured in Eastern medicine for its health-promoting properties. Now, modern science is uncovering the remarkable potential of one...

A publicly funded university in California is killing babies in abortions and turning around and using their body parts for grisly research. A leading pro-life legal group is raising the spotlight on unethical medical practices at the University of California San Francisco (UCSF) Medical Center. At UCSF, babies are killed in abortions up to 24 weeks of pregnancy, with the remains of these unborn children used for controversial scientific experiments. Reports suggest that researchers have harvested organs, such as intestines and scalps, from these viable babies and grafted them onto mice. Alexandra Snyder, the CEO of Life Legal, condemned the...

ABT-263, a senolytic drug, accelerates wound healing in aging skin by clearing senescent cells, triggering beneficial inflammation, and enhancing gene activity, offering a promising new treatment for slow-healing wounds. Topical ABT-263 effectively reduced several senescence markers in aged skin, preparing it for improved wound healing. Researchers from Boston University’s School of Medicine have identified a promising treatment that could improve wound healing in aging skin. Their study, published in the journal Aging, reveals that the drug ABT-263 can significantly accelerate skin repair by eliminating old, damaged cells known as senescent cells. As people grow older, their bodies accumulate senescent cells—cells...

Dermatofibrosarcoma protuberans (DFSP) is a rare skin sarcoma known for its high recurrence rates, making treatment particularly challenging. While surgery remains the standard option, it often leads to scarring and other complications. Current in vitro models struggle to capture the complexity of the skin tumor environment, especially the role of immune cells. Due to these issues, advancing alternative therapies that can minimize surgical impact while effectively controlling tumor growth is crucial. Researchers successfully developed patient-derived organoids from DFSP tumors, closely replicating the histological and genetic characteristics of clinical samples. Using these organoids, they tested both metformin and imatinib, a drug...

Patients with primary thyroid cancer who receive radioactive iodine therapy have an elevated risk for melanoma and other nonkeratinocyte skin cancers when limiting the cancer site to the head and neck, according to a study. Shawheen J. Rezaei and colleagues characterized the risk for subsequent melanoma and other nonkeratinocyte skin cancers in patients with primary thyroid malignant neoplasms. Standardized incidence ratios (SIRs) were calculated to estimate the risk for subsequent cancer development. The researchers found that 45.5 percent of the 174,916 patients with primary thyroid cancer diagnosed from 2000 to 2019 had first-course treatment of some form of radiation. Following...

X-ray specs and invisibility cloaks are the stuff of sci-fi and fantasy, but sometimes science is just stranger than fiction. A food dye that helps give certain sodas and snacks their hallmark orange hue renders mouse skin almost completely see-through in a reversible, potentially non-toxic research method that could transform medical and scientific imaging. Because of a counterintuitive fundamental physics principle, Tartrazine, also known as Yellow 5, can temporarily turn biological tissue transparent to the naked eye, as described in a study published September 5 in the journal Science. So far, the scientists behind the new discovery have used the...

With aging, collagen and elastin in the skin decrease, leading to sagging, fine lines and deep wrinkles. These changes often arise from oxidative stress, inflammation, and changes in enzyme activities. Collagen is the main structural protein of the extracellular matrix of connective tissue, and has a positive role in healing, bone regeneration and anti-aging of skin. The active collagen tripeptides (CPs), such as Gly-Pro-Hyp (GPH) and Pro-Hyp (PH), have shown effectiveness in anti-skin aging. In particular, CPs and elastin peptides (EPs) supplements can repair wrinkles, accelerate collagen synthesis, and play an anti-aging effect. However, despite oligopeptide collagen, CP, and EP...

Move over mosquitos. There's another blood-sucking biter Americans need to guard against because it can spread disease: the sand fly.Sand flies are tiny tan flies — about a quarter of the size of a mosquito — that live in warm, wet, rural and forested areas. In other parts of the world, they are known to transmit a parasite — a single-celled organism — that causes an infectious disease called leishmaniasis. They're most active at night, and they're so tiny they can slip through ordinary mosquito nets on tents or window screens. "Sometimes you don't even notice that you've been bitten,"...

Taylor White was only 21 when her face was tattooed with obscenities against her will, leaving her with no other option than to cover up the unsightly markings with dark, black ink. Now, more than a decade later, the Florida resident is finally removing her blackout face tattoo with the help of a generous stranger, Karridy Askenasy, otherwise known as TheDadBot. White, who formerly worked in the body-modification industry and is attempting to transition into the mental health field, said her face tattoo became an obstacle for her to land a job, and she was hurt by the rejection. “I’ve...

Is a suntan just as bad as a sunburn? Isn’t it good to get some Vitamin D from sun exposure?How bad is a suntan, really? And how do UV rays affect your skin? Although rates of indoor tanning have been dropping in the United States, many people still try to get a tan outdoors. According to a National Cancer Institute analysis of data from the 2020 National Health Interview Survey, about 39 per cent of women and 29 per cent of men in the United States had intentionally sought an outdoor tan in the past year. Yet while bronzed skin...

More than eight million people in the U.S. experience psoriasis, a condition in which skin cells build up and form itchy dry patches. A person's vitamin D levels could play an important role in psoriasis severity, according to one of the largest studies to date. The analysis, which included almost 500 psoriasis cases from the National Health and Nutrition Examination Survey (NHANES), showed a linear relationship between increasing psoriasis severity and decreasing vitamin D levels measured through blood tests. "Topical synthetic vitamin D creams are emerging as new therapies for psoriasis, but these usually require a doctor's prescription," said Rachel...

Could muscadine wine help perk up sagging skin? According to a new study, women who drank two glasses of dealcoholized muscadine wine daily showed significant improvements in the elasticity and water retention of their skin compared with those who consumed a placebo. The study is the first time scientists have studied the impacts of nonalcoholic wine consumption on skin health in a randomized clinical trial. Researchers attribute the beneficial effects to chemical compounds called polyphenols that naturally occur in many plants. Muscadine grapes are native to the Southeastern United States and are commonly used to make wine. Previous clinical trials...

New research indicates that for patients with advanced skin cancer, it may be important to maintain normal vitamin D levels when receiving immunotherapy medications called immune checkpoint inhibitors. Vitamin D has many effects on the body, including regulation of the immune system. To see whether levels of vitamin D might impact the effectiveness of immune checkpoint inhibitors, investigators analyzed the blood of 200 patients with advanced melanoma both before and every 12 weeks during immunotherapy treatment. A favorable response rate to immune checkpoint inhibitors was observed in 56.0% of patients in the group with normal baseline vitamin D levels or...

...Prostate Cancer Illustration Researchers have found that a single enzyme called PI5P4Kα can be targeted to kill prostate cancer. The discovery is the first of its kind and could help tackle treatment resistance in prostate cancer. Additionally, it could lead to better treatment options for other types of cancer, including those affecting the breast, skin, and pancreas. By inhibiting one enzyme, scientists from Sanford Burnham Prebys can kill prostate cancer cells when other treatments can’t. For the first time, researchers have discovered that prostate cancer can be killed by targeting a single enzyme, called PI5P4Kα. The findings, published recently in...

Researchers in the U.K. have developed a way to reverse the aging process in skin cells, turning back the biological clock by about 30 years. De-aging cells has become increasingly common in the last decade, with researchers reprogramming multiple mouse, rat and human cell types. But never before have cells been de-aged by so many years and still retained their specific type and function. The method, developed by Diljeet Gill, a postdoctoral candidate at the Babraham Institute in Cambridge, and his colleagues, was published April 8 in the journal eLife, and has been dubbed "maturation phase transient reprogramming." The researchers...

It's not quite the mythical fountain of youth but it is, perhaps, a start: Scientists have managed to engineer human skin cells to reverse 30 years of aging, resetting them to a much more youthful state in terms of certain molecular measurements. While it's very early days for the research – so we shouldn't get carried away too quickly – the technique could play a major part in efforts to produce rejuvenative medicine that's able to undo some of the damaging consequences of our bodies getting older. What makes the research particularly notable is that the skin cells were reprogrammed...

John Leguizamo admitted that he tries to stay out of the sun in order to stay “light-skinned” for film roles. The 57-year-old Latino actor was recently interviewed for the Academy Awards’ “Seen series,” during which he opened up about his experiences in Hollywood. “I definitely would not go in the sun for years. It was a conscious thing because I could work,” the “Romeo + Juliet” star said. “And all the Latinos that made it so far, a lot of them were all light-skinned,” he added. “What happened to all the Afro-Latinos and the majority of indigenous Latinos? They don’t...