Evaluating anti-skin aging effects of collagen tripeptide and elastin peptide formulations

Medical Xpress / KeAi Communications Co. / Journal of Dermatologic Science and Cosmetic Technology ^ | Aug. 13, 2024 | Shan Lu et al

[ConservativeMind]

With aging, collagen and elastin in the skin decrease, leading to sagging, fine lines and deep wrinkles. These changes often arise from oxidative stress, inflammation, and changes in enzyme activities.

Collagen is the main structural protein of the extracellular matrix of connective tissue, and has a positive role in healing, bone regeneration and anti-aging of skin. The active collagen tripeptides (CPs), such as Gly-Pro-Hyp (GPH) and Pro-Hyp (PH), have shown effectiveness in anti-skin aging.

In particular, CPs and elastin peptides (EPs) supplements can repair wrinkles, accelerate collagen synthesis, and play an anti-aging effect. However, despite oligopeptide collagen, CP, and EP exhibiting skin soothing and anti-aging effects confirmed in other fields, their combination effects in anti-aging have rarely been investigated.

In a study, 70 volunteers were recruited with the aim of evaluating the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged women.

"The participants were partitioned into two groups: one treated by collagen-rich drink (combination effects of different CP including tripeptide) and the other, as the placebo group," says Shan Lu.

Influences of treatments on visual skin condition scoring of volunteers. (A) Glossiness and (B) smoothness indexes were evaluated. *: Intra-group significance difference, P < 0.05; #: Inter-group significance difference, P < 0.05. Credit: Shan Lu, et al

Compared to the placebo group, the collagen drink group showed significant improvements in skin hydration, transepidermal water loss, skin elasticity, dermal collagen content, pore size, wrinkle length, skin smoothness and skin roughness decrease.

"Further, mass spectrometry demonstrated a significant increase in collagen efficacy components, including blood pH and GPH levels," adds Lu.

Overall, the study's findings support the combined use of CP and EP as dietary supplements to effectively combat skin aging in the skin of young and middle-aged.

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TOPICS: Health/Medicine
KEYWORDS: skin; skinaging

[ConservativeMind]

We make less collagen as we age. This shows up in exaggerated wrinkling, cartilage breakdown, and even hemorrhoids and varicose veins.

Cartilage is made from Type 2 (II) collagen, while skin and blood vasculature is made from Type 1 (I) with some Type 3 (III). Hemorrhoids have been found to be deficient in both Type 1 and 3, and need a higher proportion of Type 1, most.

Peptides are showing promise in tests and this approach uses a much smaller amount of collagen than gelatin or other formulations. The improvements have been shown to last many months after discontinuation, in some of these studies.

Helping our bodies restart collagen processes could have long-term benefits.

[ConservativeMind]

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[Oystir]

Why would they study the young and middle aged? It is the 55+ that show the effects of lost collagen. My understanding is that the supplements have never shown results. Seems like another, “who knows?”

[DannyTN]

[edwinland]

Is there a commercial version of that drink?

[MayflowerMadam]

Last week I began taking a concoction a church friend gave to us that helped his shoulder. He was scheduled for “shoulder reversal” surgery, and was able to cancel it.

In a mug, add 1 scoop collagen peptides; 1 tsp. finely ground cinnamon; 1 Tbs. cherry concentrate (not juice from concentrate); 2 Tbs. honey. Add 5-6 oz. warm/hot water. (I use my Keurig’s 6 oz. button.) Stir it up and drink it before it gets too thick.

We’ll see if it helps in a week or two.

[steve86]

That’s an exceptionally good overview.

[steve86]

“It is the 55+ that show the effects of lost collagen.”

I see it all the time in late 40s.

[onthelookout777]

Fish collagen peptide supplements seem to show a lot of promise for multiple health problems.

FOR TYPE 2 DIABETES:

In a double-blind study (company-funded), a fish collagen peptide supplement reduced:

- fasting blood glucose
- HbA1c
- insulin resistance

The study: https://www.iomcworld.com/open-access/a-double-blind-randomised-four-arm-clinical-study-to-evaluate-the-safety-efficacy-and-tolerability-of-collagen-peptide-as-a-nutrac-47500.html

FOR TYPE 2 DIABETES, BLOOD PRESSURE, CHOLESTEROL:

A marine collagen peptides supplement reduced:

- fasting blood glucose
- HbA1c
- diastolic blood pressure
- mean arterial pressure
- creatine
- triglycerides
- total cholesterol
- LDL

and increased:
- insulin sensitivity
- HDL

The study: https://www.sciencedirect.com/science/article/abs/pii/S0002962915314464

Some sources say marine collagen is more bioavailable than other forms of collagen.

Some sources say marine collagen peptides can improve bone density.

I’m not an expert on any of this and welcome more input.