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Evaluating anti-skin aging effects of collagen tripeptide and elastin peptide formulations
Medical Xpress / KeAi Communications Co. / Journal of Dermatologic Science and Cosmetic Technology ^ | Aug. 13, 2024 | Shan Lu et al

Posted on 08/25/2024 8:52:17 AM PDT by ConservativeMind

With aging, collagen and elastin in the skin decrease, leading to sagging, fine lines and deep wrinkles. These changes often arise from oxidative stress, inflammation, and changes in enzyme activities.

Collagen is the main structural protein of the extracellular matrix of connective tissue, and has a positive role in healing, bone regeneration and anti-aging of skin. The active collagen tripeptides (CPs), such as Gly-Pro-Hyp (GPH) and Pro-Hyp (PH), have shown effectiveness in anti-skin aging.

In particular, CPs and elastin peptides (EPs) supplements can repair wrinkles, accelerate collagen synthesis, and play an anti-aging effect. However, despite oligopeptide collagen, CP, and EP exhibiting skin soothing and anti-aging effects confirmed in other fields, their combination effects in anti-aging have rarely been investigated.

In a study, 70 volunteers were recruited with the aim of evaluating the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged women.

"The participants were partitioned into two groups: one treated by collagen-rich drink (combination effects of different CP including tripeptide) and the other, as the placebo group," says Shan Lu.

Influences of treatments on visual skin condition scoring of volunteers. (A) Glossiness and (B) smoothness indexes were evaluated. *: Intra-group significance difference, P < 0.05; #: Inter-group significance difference, P < 0.05. Credit: Shan Lu, et al

Compared to the placebo group, the collagen drink group showed significant improvements in skin hydration, transepidermal water loss, skin elasticity, dermal collagen content, pore size, wrinkle length, skin smoothness and skin roughness decrease.

"Further, mass spectrometry demonstrated a significant increase in collagen efficacy components, including blood pH and GPH levels," adds Lu.

Overall, the study's findings support the combined use of CP and EP as dietary supplements to effectively combat skin aging in the skin of young and middle-aged.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: collagen; skin; skinaging
We make less collagen as we age. This shows up in exaggerated wrinkling, cartilage breakdown, and even hemorrhoids and varicose veins.

Cartilage is made from Type 2 (II) collagen, while skin and blood vasculature is made from Type 1 (I) with some Type 3 (III). Hemorrhoids have been found to be deficient in both Type 1 and 3, and need a higher proportion of Type 1, most.

Peptides are showing promise in tests and this approach uses a much smaller amount of collagen than gelatin or other formulations. The improvements have been shown to last many months after discontinuation, in some of these studies.

Helping our bodies restart collagen processes could have long-term benefits.

1 posted on 08/25/2024 8:52:17 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 08/25/2024 8:55:41 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Why would they study the young and middle aged? It is the 55+ that show the effects of lost collagen. My understanding is that the supplements have never shown results. Seems like another, “who knows?”


3 posted on 08/25/2024 10:31:51 AM PDT by Oystir ( )
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To: ConservativeMind

4 posted on 08/25/2024 10:43:54 AM PDT by DannyTN
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To: ConservativeMind

Is there a commercial version of that drink?


5 posted on 08/25/2024 11:57:13 AM PDT by edwinland
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To: ConservativeMind

Last week I began taking a concoction a church friend gave to us that helped his shoulder. He was scheduled for “shoulder reversal” surgery, and was able to cancel it.

In a mug, add 1 scoop collagen peptides; 1 tsp. finely ground cinnamon; 1 Tbs. cherry concentrate (not juice from concentrate); 2 Tbs. honey. Add 5-6 oz. warm/hot water. (I use my Keurig’s 6 oz. button.) Stir it up and drink it before it gets too thick.

We’ll see if it helps in a week or two.


6 posted on 08/25/2024 12:26:46 PM PDT by MayflowerMadam (I'm voting for the convicted felon with the pierced ear. )
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To: ConservativeMind

That’s an exceptionally good overview.


7 posted on 08/25/2024 12:54:39 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: Oystir

“It is the 55+ that show the effects of lost collagen.”

I see it all the time in late 40s.


8 posted on 08/25/2024 12:56:33 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: All

Fish collagen peptide supplements seem to show a lot of promise for multiple health problems.

FOR TYPE 2 DIABETES:

In a double-blind study (company-funded), a fish collagen peptide supplement reduced:

- fasting blood glucose
- HbA1c
- insulin resistance

The study: https://www.iomcworld.com/open-access/a-double-blind-randomised-four-arm-clinical-study-to-evaluate-the-safety-efficacy-and-tolerability-of-collagen-peptide-as-a-nutrac-47500.html

FOR TYPE 2 DIABETES, BLOOD PRESSURE, CHOLESTEROL:

A marine collagen peptides supplement reduced:

- fasting blood glucose
- HbA1c
- diastolic blood pressure
- mean arterial pressure
- creatine
- triglycerides
- total cholesterol
- LDL

and increased:
- insulin sensitivity
- HDL

The study: https://www.sciencedirect.com/science/article/abs/pii/S0002962915314464

Some sources say marine collagen is more bioavailable than other forms of collagen.

Some sources say marine collagen peptides can improve bone density.

I’m not an expert on any of this and welcome more input.


9 posted on 08/25/2024 1:13:38 PM PDT by onthelookout777
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To: ConservativeMind

Thanks. I used to drink collagen everyday. Then scar tissue was growing so much after cancer surgery I quit, because I didn’t know if collagen was helping the unwanted growth.
Thinking of starting again.


10 posted on 08/25/2024 2:55:16 PM PDT by Rusty0604 (W looking for new conspiracy theories as all the old ones have come true)
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To: onthelookout777

“Some sources say marine collagen is more bioavailable than other forms of collagen.”

Thanks for that info.


11 posted on 08/25/2024 4:14:16 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: onthelookout777; ConservativeMind

As with other marine products, concern has been expressed that toxic heavy metals may be found in certain lots. I don’t know how meaningful this concern is regarding the frequency of this occurrence. Maybe just take a slightly higher dose of non-marine sourced product to make up for the poorer absorption?


12 posted on 08/25/2024 4:57:27 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: steve86

Thanks, Steve. After reading your comment, I found a paper with test results of heavy metal content of many collagen supplements. Unfortunately, it was back in 2020, so not fully up to date.

On page 10, they list the products they tested and the amounts of heavy metals that were found.

I haven’t read the whole paper and don’t know how much of a concern these amounts of heavy metals are.

On page 7, they list the 3 products with the lowest levels of heavy metals.

https://cleanlabelproject.org/collagen-white-paper/


13 posted on 08/25/2024 5:55:15 PM PDT by onthelookout777
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To: steve86

Wait till you hit the cliff called 55


14 posted on 08/26/2024 12:22:54 PM PDT by Oystir ( )
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To: Oystir

That was 15 years ago.


15 posted on 08/26/2024 3:09:15 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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