During the past 2.6 million years, Earth’s climate has alternated between warm periods known as interglacials, when conditions were similar to those of today, and cold glacials, when ice sheets spread across North America and northern Europe. Before about 1 million years ago, the warm periods recurred every 40,000 years, but after that, the return period lengthened to an average of about 100,000 years. It has often been suggested that a decline in the atmospheric concentration of carbon dioxide was responsible for this fundamental change. Writing in Nature, Yan et al.1 report the first direct measurements of atmospheric CO2 concentrations...