Cardiovascular disease (CVD) often starts with the buildup of lipid deposits or plaques within the blood vessel, setting the stage for atherosclerosis. Rupture of these atherosclerotic plaques clot blood vessels and lead to life-threatening conditions including heart attack or stroke. Dyslipidemia, meaning having too much "bad" or atherogenic lipids in the blood, represents the most common cause of CVDs. Accordingly, doctors often prescribe lipid-lowering medications. In two studies, researchers found a novel approach to achieve intensive lipid lowering, which enabled reversal of atherosclerotic plaques in murine disease models. This potential therapy employs a previously unknown function of the essential element...