Posted on 11/05/2023 7:17:40 AM PST by ConservativeMind
Cardiovascular disease (CVD) often starts with the buildup of lipid deposits or plaques within the blood vessel, setting the stage for atherosclerosis. Rupture of these atherosclerotic plaques clot blood vessels and lead to life-threatening conditions including heart attack or stroke.
Dyslipidemia, meaning having too much "bad" or atherogenic lipids in the blood, represents the most common cause of CVDs. Accordingly, doctors often prescribe lipid-lowering medications.
In two studies, researchers found a novel approach to achieve intensive lipid lowering, which enabled reversal of atherosclerotic plaques in murine disease models.
This potential therapy employs a previously unknown function of the essential element manganese. Increasing doses of extra manganese, even when conveniently provided to mice via diets, dramatically reduce blood lipids and clear out the atherosclerotic plaques that have already built up in the blood vessels.
Dr. Xiao Wang, explains, "Manganese is considered as the least understood essential element, mainly playing supporting roles in enzymatic reactions. Yet, we've uncovered an active, signaling role of the manganese ion in controlling lipid delivery into the blood."
Bulk lipids, including cholesterol and triglycerides, are transported into the blood via lipoproteins. These are much larger and more complex compared to other secretory factors in the blood.
The researchers discovered that these lipid-ferrying lipoproteins rely on the biomolecular condensation of a common cellular machinery, known as the coat protein complex II (COPII) complex. Moreover, COPII condensation needs to be finely balanced at the right level to support bulk lipid delivery.
After dissecting a series of unexpected observations, the researchers further discovered that manganese ions could directly bind COPII and enhance its condensation. This in turn alters the fine balance in COPII regulation, resulting in a unique, bell-shaped regulation on blood lipid levels. The novel mechanism ultimately enabled the manganese-based therapy that could clear plaques in mice bearing CVDs.
(Excerpt) Read more at medicalxpress.com ...
BUMP
The top sources of manganese in the diets of U.S. adults are grain products, tea, and vegetables [4].
I am a tea drinker. Something I inherited from my mom and dad. Thanks Mom and Dad!
This is an easy fix to health problems much to the chagrin of big pharma.
Building upon junk science.
If this had any foundation, I’d already be dead.
If I’m labeled merely an ‘outlier’, then I’m evidence of alien life on our planet.
You never eat food that has manganese in it?
Absolutely not.
I’m a paid shill directed by the establishment to discredit so-called ‘alternative health’ claims by strictly adhering to a processed food diet and my family will be handsomely rewarded should the outcome prove to be consequential.
/s
OR...
I could be describing decades of gaslighting via corporate advertising while the regulators play ‘see no evil/hear no evil’ until they are provided proof of disease or death.
All the while they play the ‘lipid hypothesis’ fiddle while Rome burns and invent all manner of jackassery to rationalize the growing body of evidence against the health narrative.
Thanks for this post.
I have about 50% blockage of my carotids. I don’t know whether the plaque is hard or soft plaque. I’m guessing that at least 50% of that plaque is soft because there was a big increase of the plaque in the last year.
My centrum multivitamin has about 4 mg of Manganese. If I hear this article and comments correctly—I can add another 7 mg of magnesium for a total of 11 mg. ‘
In theory the extra Manganese will help to lower the plaque.
Correct?
Soybeans are a good source of manganese, as is brown rice.
https://www.nutritionadvance.com/foods-high-in-manganese/
You also need to subtract out your other food sources, from the day.
You might only be able to add 2.5 - 5 mg of manganese, as a result.
Brown rice is high in oxalates, so is not for kidney stone sufferers.
Manganese VS Magnesium
from Healthline:
Manganese and magnesium are two of the essential minerals. You need to consume enough of each on a regular basis to keep your body working properly.
Though their names sound similar, manganese and magnesium have distinct roles in the body.
One thing that I could not figure out —was how the doses of manganese fed to mice translated to doses for humans. did you understand that?
The doses used varied from 5 mg/kg to 50 mg/kg.
None of those doses, quite larger than the Upper Tolerable Limit for humans, caused any liver enzyme or creatinine changes.
That is, 5 mg/kg - 40 mg/kg.
I weigh 170lb.
When I converted the low number 5 mg/kg to mg/lb... I got very roughly 34g mg. as being the equivalent manganese dose for a 170 person.
Does that sound about right to you?
I stop at the Upper Tolerable Limit.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.