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Research has shown amiloride is as effective as spironolactone in reducing systolic blood pressure (SBP) over 12 weeks in patients with resistant hypertension. Spironolactone is a fourth-line medication. Adverse effects, particularly hyperkalemia and hormonal disruptions, limit its use in long-term care. Amiloride, a potassium-sparing diuretic, lacks these hormonal side effects, making it a potential replacement candidate. In the study, researchers conducted a prospective, open-label, blinded end-point trial to assess whether amiloride could provide comparable SBP reduction to spironolactone in patients with resistant hypertension. Researchers enrolled 118 participants at 14 hospitals across South Korea. Participants ranged in age from 19 to...

[Catholic Caucus] Let the Forgetting BeginOver the length of the Francis pontificate, those with even a slight whiff of concern were labeled “anti-Francis,” or having “attacked” Francis, or had even become heretics.The Francists are playing defense now, fighting a rear-guard action against those who have questioned certain actions, thoughts, and even “teachings” of Pope Francis. There is an odor of desperation among them. After all, we have had a sometimes rocky 12 years. The Francists know this, though they would put all the blame on Taylor Marshall. Over the length of his papacy, those with even a slight whiff of...

Please join with fellow FREEPERS to pray for AMERICA: For those in Authority in Government, Family, Military, Business, Healthcare, Education, Churches, and the Media.1 Timothy 2:1-2 I urge, then, first of all, that requests, prayers, intercession and thanksgiving be made for everyone: for kings and all those in authority that we may live peaceful and quiet lives in all godliness and holiness.Religion Forum threads labeled “Prayer” are closed to debate of any kind.

The riots followed Paris Saint-Germain's victory in the Champions League game.At least two people were killed and hundreds more were injured in Paris following a European soccer championship, as protesters waved Palestinian flags and clashed with police. Chaos erupted across the city after thousands of people took to the streets to celebrate Paris Saint-Germain winning the Champions League, the most prestigious title in European soccer. Videos and photos from the riots showed people clashing with police, crashing through barriers, destroying vehicles, climbing monuments, and causing mayhem. Protesters waived Palestinian flags amid the chaos, following an anti-Israel protest during the championship...

You’d think an elderly woman getting burned alive at a pro-Israel event by a man hurling Molotov cocktails while screaming “This will end when Palestine is free” would be universally condemned as terrorism. But this is 2025, with the media’s moral compass still spinning wildly and antisemitism extremely fashionable on the political left. So, instead of acknowledging the obvious, CNN went into full denial mode the moment the FBI under Director Kash Patel called the Boulder firebombing exactly what it was: a targeted terror attack. Despite the local police chief declining to confirm whether the Boulder attack was targeted, the...

ATTENTION!So, it appears Zelenskyy gave the go ahead to attack parked Russian nuclear capable bombers without informing @realDonaldTrump (if true that our President was not consulted nor informed, this isn’t simply a breach of protocol. It’s a geopolitical insult and a warning sign. If Ukraine is willing to conduct strikes with strategic consequences without notifying the White House, we are no longer allies with coordination issues—we are co-belligerents flying blind).Also given Senator “warmonger” Lindsey Graham’s and Senator “Da Nang Dick” Blumenthal’s recent visit, this attack could appear as though it was sanctioned. I pray the Russians have better intelligence than...

Ipsos poll, which includes some partial results, puts Nawrocki on 51% and his pro-European rival, Rafał Trzaskowski, on 49%Overnight projections from Poland’s crucial presidential run-off showed a narrow lead for the right-wing candidate Karol Nawrocki, as votes continued to be counted. A set of preliminary results combining exit polls and counted ballots, published at 1am local time on Monday morning (midnight BST), gave Nawrocki a 51-49% lead over liberal contender Rafał Trzaskowski, an ally of the ruling government led by Donald Tusk. Nawrocki’s lead was a dramatic reversal of projections, after an exit poll, published as voting concluded, appeared to...

SEOUL (Reuters) - South Korea's factory activity shrank for a fourth month in May as frail domestic demand and the impact of U.S. tariffs took a heavy toll on factory output while overall orders plunged at their steepest pace in five years, a business survey showed on Monday. The Purchasing Managers Index (PMI) for manufacturers in Asia's fourth-largest economy, released by S&P Global, edged up to 47.7 in May, from 47.5 in April. The index has stayed below 50-mark, which separates expansion from contraction, since February. "South Korea's manufacturing sector came into May on an unstable footing," said Usamah Bhatti,...

France is no longer France.

Anti-ICE activists intervened and obstructed the officers, with one individual later posting a video online bragging about running the agents out of the area. Immigration and Customs Enforcement (ICE) agents in Boston were forced to abandon an operation after a crowd of activists surrounded their vehicle and blew their cover while they were surveilling the home of an illegal immigrant wanted for murder. According to Fox News’ Bill Melugin, who was covering immigration in Boston this week, the agents was in close proximity to a school during the operation in order to arrest a murder suspect. Activists intervened and obstructed...

As the administration continues to remake the federal bureaucracy to President Trump’s liking, the Office of Personnel and Management has developed an intensive new training program for those aspiring to join the Senior Executive Service, the upper echelon of government employees. Per an OPM memo, obtained first by RealClearPolitics, the syllabus includes course work grounded in the U.S. Constitution, “Founding ideals of our government,” and Trump’s own executive orders. The development program requires 80 hours of video-based training and culminates in two days of in-person training in Washington, D.C. It will affect government employees across the administration and disparate agencies...

A research team has unveiled the cause and molecular mechanism of chronic brain inflammation that results in repetitive behavioral disorders. The research team demonstrated that an inflammatory response by immune cells in the brain induces overactivity in certain receptors, which may, in turn, lead to the meaningless repetitive behaviors observed in people with autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD). The research involved mice with a mutated NLRP3 gene. This gene mutation stimulates a chronic inflammatory response by immune cells in the brain that are called microglia. Prolonged inflammation overactivates N-methyl-D-aspartate (NMDA) glutamate receptors, which are important for excitatory...

In a dramatic incident captured on video, U.S. Department of Homeland Security police Wednesday handcuffed one of Rep. Jerry Nadler aides in the congressmember's Manhattan office, which is in the same federal office building as an immigration courthouse. In the video, which was shared with Gothamist and filmed by a person who was monitoring activity in immigration court, DHS officers entered Nadler’s district office and accused staff members of “harboring rioters.” A Nadler staffer is seen crying and being handcuffed. Another officer is at a door trying to enter a private area of the office while a staffer asks for...

Boulder attacker Mohamed Sabry Soliman, 42, was in the country Illegally He’s an Egyptian national who arrived during the Biden administration on a B-2 visa and never returned home.

For the freedom you enjoyed yesterday... Thank the Veterans who served in The United States Armed Forces. Looking forward to tomorrow's freedom? Support The United States Armed Forces Today! ~ Hall of Heroes ~Lt. Cdr. Edward "Butch" O'Hare Info from here. Edward Henry Butch O'Hare (March 13, 1914 – November 26, 1943) was born in St. Louis, Missouri to Edward Joseph O'Hare and Selma O'Hare. Butch had two sisters, Patricia and Marilyn. When their parents divorced in 1927, Butch and his sisters stayed with their mother Selma in St. Louis while their father Edward moved to Chicago. Butch's father...

Olivia Dunne showed off her gymnastics skills on the runway with a jaw-dropping move during the Sports Illustrated Swimsuit Fashion Show over the weekend. The national champion gymnast strutted down the walkway in a black and white polka dot bathing suit that featured red bows in the front and down toward her hips. As she reached the end of the aisle, she dropped down in a split. Dunne smiled as she received some applause from the crowd that packed the show. As she walked back up the runway, she touched hips with musician Xandra Pohl. Dunne also wore a bikini...

Secretary of State Marco Rubio doubled down on President Trump’s demand for peace talks between Ukraine and Russia after the war escalated over a weekend with a series of intense bombings inside both countries. Rubio told Russian Foreign Minister Sergey Lavrov on Sunday that both sides needed to engage in direct talks “to achieve a lasting peace,” according to the State Department. The message came after Ukraine’s forces wiped out and damaged 41 of the Kremlin’s nuclear bombers and aircraft, attacking at least four air bases across Russia in a massive operation.

Streaks of colorful light could paint the sky over a large portion of the country on Sunday night into Monday morning amid a severe geomagnetic storm.A geomagnetic storm is expected to set skies aglow in the northern part of the United States on Sunday night into early Monday morning, with the northern lights potentially visible as far south as Alabama to Northern California, according to the National Oceanic and Atmospheric Administration’s Space Weather Prediction Center.The geomagnetic storm reached severe strength early Sunday morning. Though it was not expected to be as intense as the one in May 2024 that flooded...

VIDEOHere is a summary of the WILD experiences I had in Portugal over the course of 11 days from May 20 to May 31 which feels more like a couple of months. This is just a summary of what I will show in more detail with photos and videos over the course of the next few weeks which will be posted on weekends. Some of what you are about to see and hear appears no where else and hopefully will save you a lot of money and grief if you decide to visit that magical country.I barely scratched the surface...

Hand it to the Ukrainians: They’re not only fighting heroically on, more than three years after Moscow launched its savage and utterly unprovoked war to destroy their nation, they’re fighting with cheek and style. The latest, of course, is Sunday’s surprise drone strikes on airbases deep inside Russia, targeting strategic warplanes that have been pummeling mostly-civilian targets in Ukraine. It counts as an intelligence coup, too: The drones were infiltrated to near their final targets over months, with Vladimir Putin’s massive internal-surveillance agencies left utterly in the dark. Then again, Vlad’s secret police were caught clueless back when the Wagner...