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Researchers have synthesized complex menthyl esters and uncovered the mechanism by which they interact with the liver X receptor. Researchers developed menthyl esters with significant anti-inflammatory and anti-obesity effects, potentially offering new treatments for chronic inflammatory conditions and metabolic disorders. Recent therapeutic advances and commercial successes have often been driven by modified derivatives of natural products. Menthol, a naturally occurring cyclic monoterpene alcohol, is found in various plants, especially in mint family members like peppermint and spearmint. It is widely used in confectionery, chewing gum, and oral care products. Notably, menthol also possesses significant medicinal properties, including analgesic, anti-inflammatory, and...

A long-profitable niche for American car makers has been the all-American muscle car. Low-slung, two door sedans with enormous horsepower, wide tires, aggressive styling and the low rumble of those powerful V-8 engines. There’s nothing quite like them, and they sell for a premium. Ford made the Mustang, Chevy the Camaro, and Dodge, the Charger and Challenger. They were initially designed to go fast in a straight line, but as technology improved and suspensions became more sophisticated, they began to hold their own on the racetrack as well as the drag strip, and their internal amenities began to rival luxury...

I am passing along this note of thanks from Ali's mom and dad Dalainna sent you a thank you for donating to Help us support Ali Rose I hope you're doing well! We just wanted to take a moment to say a big thank you for your generous donation. We apologize for the delay in reaching out—we finally had a chance to look at the GoFundMe, and we can't express how much your support means to us. Ali has been home for almost two months now and is doing amazing! She's busy with PT four times a week, OT two...

By now, the diversity, equity, and inclusion (DEI) industry’s capture of academia, business, and government is obvious to most Americans. From former Harvard president Claudine Gay’s televised equivocations before Congress to the unhinged, violent student and faculty occupations in support of Hamas at some of America’s most elite universities, many are no doubt wondering if DEI is producing something counter to its placid-sounding words. That this shameful behavior is occurring at civilian institutions of higher learning is probably no surprise to most observers. Unfortunately, DEI has metastasized beyond the confines of the civilian world and found a willing host in...

In President Joe Biden’s proposal in the Fiscal Year 2025 Budget of the United States Government, and more specifically in the General Explanations of the Administration’s FY 2025 Revenue Proposals, the Biden administration has proposed a slate of bold shifts in tax policy that could redefine high income tax planning and investment strategies. Among the most striking initiatives in the FY2025 Budget Proposal is a set of proposals taxing unrealized gains—a concept ---SNIP-- . A shift in tax policy towards tapping revenue streams in unrealized gains is almost certainly on the horizon-

This is a very challenging operation. Rescue services say they have teams of specialist divers who are used to working in small, cramped quarters. The depth of the shipwreck is proving a big challenge. They have also been hampered, we’ve been told, by the fact that the boat is lying on its side and the access points are choked with debris, so it’s very difficult to gain access to the yacht itself. What we understand is that they want today to try and get into a cabin where some of the missing may have been sleeping. The rescue services know...

The largest event for the LGBTQ+ community is months away in downtown Orlando. Come Out With Pride is back this year for its 20th anniversary at Lake...But finding details about it on VisitFlorida.com is currently not an option. The LGBTQ+ travel section is gone with no explanation. The section previously featured blog posts and videos related to the state’s

House Speaker Mike Johnson (R-La.) slammed the Biden administration after a “stunning” inspector general’s report released Tuesday found nearly 300,000 migrant children have gone missing in the US. “This administration’s failure to secure our border is facilitating what is the equivalent of a modern-day slavery operation,” Johnson told reporters on a press call Tuesday evening. “The southern border is a national security disaster and a humanitarian catastrophe and Kamala Harris cannot be trusted to fix it,” he thundered. “And this is one of the biggest scandals in American history; it’s one of the most tragic; and we have to hold...

Remember 2019? The Trump administration's border policies were causing the Left to lose their minds, and they were fixated on "kids in cages," which was a slur on how the administration housed unaccompanied minors. Rising Democrat star Alexandria Ocasio-Cortez even went down to the border, all dressed in white, and staged a dramatic show, calling them concentration camps.

In Sweetwater County, Republican voters split in electing representatives, sending two incumbents packing and putting incumbent Reps. J.T. Larson and Cody Wylie, both of Rock Springs, back in Cheyenne. Challengers Darin McCann and Marlene Brady will represent Sweetwater County after ousting incumbent Reps. Clark Stith of Rock Springs and Tony Niemiec of Green River, according to complete but unofficial results. snip “I’m kind of saddened, not just for me,” said Niemiec, one of two Sweetwater incumbents upset by the Freedom Caucus tide. “It looks like the Freedom Caucus will be in power in the House.” He predicted “cuts, cuts, cuts”...

CHEYENNE — Laramie County’s currently longest-serving state legislator, Rep. Dan Zwonitzer, and his father, Rep. David Zwonitzer, both lost their seats in Tuesday’s primary. The Cheyenne Republican lawmakers were ousted by their Wyoming Freedom Caucus-endorsed opponents, Ann Lucas in House District 44 and Steve Johnson in HD 8.

Rep. Albert Sommers (R-Pinedale) lost to a political newcomer in a close-fought contest for a state Senate seat Tuesday, an upset that ousts one of the most influential figures in Wyoming politics in recent years. Laura Taliaferro Pearson, a sheep rancher and school bus driver who lives north of Kemmerer, thanked the residents of her four-county district late on Tuesday as she held onto a small lead. The Associated Press called the race around 11 p.m., when Pearson topped Sommers by a 3.4% margin. “I’m thrilled to be a senator representing our great state,” she told WyoFile. “It means the...

Microsoft warned customers this Tuesday to patch a critical TCP/IP remote code execution (RCE) vulnerability with an increased likelihood of exploitation that impacts all Windows systems using IPv6, which is enabled by default. Found by Kunlun Lab's XiaoWei and tracked as CVE-2024-38063, this security bug is caused by an Integer Underflow weakness, which attackers could exploit to trigger buffer overflows that can be used to execute arbitrary code on vulnerable Windows 10, Windows 11, and Windows Server systems.

Freedom Caucus contender Darin McCann, R-Rock Springs, beat State House District 48 Rep. Clark Stith in a stunning upset in the Republican primary race in Sweetwater County that turned heated over accusations of “crossover voting.” The loss for Stith, R- Rock Springs, the speaker pro tempore, was tough to swallow for the legislator who was seeking a full fourth term in office. "Serving in the Wyoming Legislature was the honor of a lifetime,” Stith told Cowboy State Daily. “Voters in my district want change and change they’ll get,” Stith added. “They will get anti-government change. I expect less support for...

The Wyoming Legislature will look distinctly different when it convenes for its 68th session in January. In Tuesday night’s Republican primary, longtime legislators went down left and right. Most notable was House Speaker Albert Sommers, R-Pinedale, who lost his bid for Senate District 14 to Kemmerer resident Laura Taliaferro Pearson by 156 votes. Sommers had served in the Legislature since 2013. The main beneficiary of the upheaval: The Wyoming Freedom Caucus, a conservative movement that has positioned itself farther right of more mainstream conservatives, including many incumbents its members have deemed to be part of the “establishment.” All together, Cowboy...

President Donald J. Trump, 45th President of the United States of America, and Vice Presidential Nominee, Senator JD Vance will deliver remarks on National Security in Asheboro, North Carolina on Wednesday, August 21, 2024, at 2:00PM EDT. Since weak, failed, and dangerously liberal Kamala Harris took office America has become a global laughingstock. From our wide-open border to the botched Afghanistan withdrawal to the Hamas-Israeli war to enabling the Iranian terrorist regime, this Administration’s weakness on the world stage has put America’s national security in jeopardy and brought us to the brink of World War III. Kamala Harris played a...

“Let your character be free from the love of money, being content with what you have; for [the Lord] Himself has said, ‘I will never desert you, nor will I ever forsake you’” (Hebrews 13:5). God promises to provide for all your needs. In World War II the death of many adults left many orphans. At the close of the war, the Allies provided some camps to feed the orphans and to try and find a place to relocate them. The children began to develop and grow, receiving the finest food and care. But in one of the camps, the...

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The process of buying a home comes with many, many decisions. This barrage of choices starts immediately with deciding which online platform to use to search for potential homes. While the choice was once primarily between online real estate giants Zillow and Realtor.com, there's now a new number-two competitor in town: Homes.com. You may have seen their ads — especially during Superbowl LVIII — featuring big-name celebrities like Jeff Goldblum, Dan Levy, and Heidi Gardner. But does Homes.com's rapid growth mean that it's a better platform? Not necessarily. It all depends on what you're looking for. Meanwhile, Zillow's name continues...

Vice President Kamala Harris has enjoyed a noticeable surge in the polls – particularly national polls – since becoming the Democratic standard bearer, but the rapid shift in her position has left some industry analysts questioning the apparent boost in the formerly quite unpopular vice president’s standing. In her 2020 run, she struggled to break 3% before dropping out, according to The Hill. Prior to becoming the Democratic nominee, Harris suffered from decidedly poor approval ratings and Trump initially held the lead over her in a head-to-head matchup. The average quickly flipped, however, in the wake of several surveys showing...