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Fluorescence microscopy images showing the endoplasmic reticulum network (green) wrapping around damaged lysosomes (red). The cell nucleus is shown in blue. Today in Nature, University of Pittsburgh researchers describe for the first time a pathway by which cells repair damaged lysosomes, structures that contribute to longevity by recycling cellular trash. The findings are an important step towards understanding and treating age-related diseases driven by leaky lysosomes. "Lysosome damage is a hallmark of aging and many diseases, particularly neurodegenerative disorders such as Alzheimer's," said lead author Jay Xiaojun Tan, Ph.D., assistant professor of cell biology at Pitt's School of Medicine...

Glenn Greenwald has been dealing with some family health issues lately and it has kept him from weighing in on political issues, but last night he found the time to post a thread on Twitter which is worth your time. Greenwald methodically points out how the left is systematically stifling dissent through coordination with various people and elements of the state and the media. This is disturbing but a must-read: *********************************************************** The regime of censorship being imposed on the internet – by a consortium of DC Dems, billionaire-funded "disinformation experts," the US Security State, and liberal employees of media corporations...

An updated look and forecast of the 2022 US Senate Elections, approximately two months out. Prediction: GOP: 53 Dem: 47

A Few Good Women sprang out of a community effort to help beautify Karen Hicks's neighborhood at 87th and Ingleside and spread outward from there. “We are a group of women that give love and support at any level,” Hicks told Chicago City Wire. “We started with our mass campaign of cleaning up. We call it the 'pop up cleanup.' We go to different communities westside, Southside. What really got it was the trash that I was seeing on the expressway over three years ago. The trash has gotten to be just unbelievably abundant in our communities. So we began...

NEW YORK, UN. Sept 7 (Interfax) - UN Secretary General Antonio Guterres said on Tuesday he believes that the area around the Zaporizhzhya Nuclear Power Plant should become a demilitarized zone, while the Ukrainian side should pledge not to move into this territory. "An agreement on a demilitarized perimeter should be secured," Guterres said at a UN Security Council meeting. "That would include the commitment by Russian forces to withdraw all the military personnel and the equipment from this perimeter and the commitment by the Ukrainian forces not to move into it," he said. "The Zaporizhzhya facility and its surrounding...

University COVID-19 vaccine mandates are unethical because the vaccines are up to nearly 100 times more likely to cause a person of student age serious injury than prevent him or her from being hospitalised with COVID-19, a new study has concluded. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4206070 The study, whose authors include Dr. Kevin Bardosh, a recipient of funding from the pro-vaccination Wellcome Trust led by Sir Jeremy Farrar, and Dr. Tracy Beth Høeg of the Florida Department of Health, presents a risk-benefit assessment of booster vaccines among people of student age and provides five ethical arguments against mandates. The researchers estimate that 22,000-30,000 previously...

Anew study is raising concerns about the effectiveness of the monkeypox vaccine being used in the United States and other parts of the world. The work, which has not yet been peer-reviewed, found that two doses of the vaccine induced relatively low levels of neutralizing antibodies against the monkeypox virus, and those antibodies had poor neutralizing capacity. The researchers noted the so-called correlates of protection — what is needed, in terms of immune system weaponry, to be protected against monkeypox — are not known. Still, the evidence of low levels of neutralizing antibodies raises questions about how much protection is...

A Washington State teenager has gone from missing person to the subject of a murder investigation, police said. Gabriel Michael Davies, 16, of Olympia, was reported missing last Wednesday after failing to show up to football practice, according to the Tacoma News Tribune. Authorities located found the football player’s vehicle near Millersylvania State Park. Davies himself was found late Thursday in what police termed “suspicious circumstances.” Gabriel Michael Davies, 16, was reported missing last Wednesday after failing to appear at football practice. Detectives reportedly found a small amount of blood and a smashed cell phone around Davies’ car. Although the...

Today I did this search on Brave using the Brave search engine: "when did trump declassify documents" These are the sources that came up, in order: CBS NBC WSJ Washington Post NY Times Missouri Independent CNN Politico Washington Post FactCheck The Guardian The Hill WSJ Newsweek ALL are liberal sources. Then I used Duckduckgo: Yahoo NY Times WSJ FactCheck Townhall WeLoveTrump Politico ABC PJ Media Yahoo Substack PolitiFact NY Post Rawstory WSJ Washington Post SKEWS to the liberals, but definitely more variety

No doubt there are hundreds or even thousands of articles opining on how the democrats came out on top of the 2020 election (note I didn’t say ‘win’). Few if any gave possible opinions or evidence on our own culpability in what happened between November 3rd and 4th in 2020. As the saying goes, “Those who do not learn from history are doomed to repeat it.” I can testify that mistakes were clearly made on our side, and in order to save the Republic, we need to honestly look at what we have done (or in this case – did...

ATLANTA, GA — CDC Director Dr. Rochelle Walensky held a press conference to warn the public about a deadly new "stealth" COVID-19 variant that causes negative test results and causes no symptoms. "This deadly variant has bypassed our most sophisticated tests by ingeniously becoming harmless to the human body," said Director Walensky, "It is estimated that eight billion people have caught this variant. We must prevent it from spreading further by closing schools and locking up kindergarten children." The CDC director's guidance to close schools and stem the tide of this "stealth" variant is backed by data that has been...

The California legislature just passed S.B. 107, a dangerous bill that undermines the fundamental right of every parent in every state to direct the upbringing of their children. It allows California courts to strip custody from parents — even parents who don’t live in California — who have legitimate concerns about a young child undergoing irreversible medical procedures to appear as a different gender. California wants to become a “sanctuary state” to which minor children from around the country can flee (or even be taken by someone else) to obtain on-demand puberty blockers, cross-sex hormones, or surgeries to remove healthy...

VIDEOYes, Ol' PJ and the wife are heading for the southern Caribbean aboard the Celebrity Equinox from September 8 until September 17. I know it is a cruel thing to leave you bereft of the DUmmie FUnnies videos during that time period but I really need to recharge my batteries.

This fall, Apple will make some of its flagship iPhones outside China for the first time, a small but significant change for a company that has built one of the most sophisticated supply chains in the world with the help of the Chinese authorities. But the development of the iPhone 14, which is expected to be unveiled on Wednesday, shows how complicated it will be for Apple to truly untangle itself from China. More than ever, Apple’s Chinese employees and suppliers contributed complex work and sophisticated components for the 15th year of its marquee device, including aspects of manufacturing design,...

Trump-hating comedian Kathy Griffin suggested civil war will be waged if people do not vote for Democrats in November.In a psychotic tweet on Tuesday, the actress said voting for Republican would descend the country into a “civil war.”“If you don’t want a Civil War, vote for Democrats in November. If you do want Civil War, vote Republican,” Griffin, 61, tweeted, just days after Joe Biden’s revolting speech declaring Trump supporters “extremists” and enemies of the state.If you don’t want a Civil War, vote for Democrats in November. If you do want Civil War, vote Republican.— Kathy Griffin (@kathygriffin) September 6,...

Stacey Lyn Chahorski of Norton Shores, Michigan, was reported missing in January 1989. But it wasn't until earlier this year that authorities confirmed through a new type of genealogy investigation that a body found in Georgia's Dade County in December 1988 belonged to Chahorski. Now, that same technology has been used to identify her killer as Henry Fredrick "Hoss" Wise, officials with the Georgia Bureau of Investigation and the Federal Bureau of Investigation announced Tuesday. Wise also worked as a truck driver for Western Carolina Trucking, traveling through Dade County on his regular route. He had a criminal history in...

A public school teacher in Johnston County is accused of several sex offenses, including the statutory rape of a kid under the age of 15. English teacher Amanda Doll, 37, of Benson’s West Johnston High School was detained on September 2. According to online court documents, Doll was charged with three felonies: statutory rape of a kid under the age of 15, having intercourse with a student and engaging in indecent acts with a child. Doll is being held on $1 million dollar bond. She had requested a lower bail so she could return home to her four children.

Terence Graham has been waiting anxiously for weeks to receive urgent CT scan results after experiencing "noticeable swelling" in the back of his head that gave him "blinding headaches." The 55-year-old Canadian Forces veteran, who lives in Laird, Ont., about 40 kilometres southeast of Sault Ste. Marie, said he was checked out at the local emergency department on July 27. Not only did it take nearly three weeks to get the scan, he says he's since been unable to get the results. The findings of a new Angus Reid Institute poll conducted in Canada and the U.S. in August suggest...

Tehran (AsiaNews) – Iran will become a full member of the Shanghai Cooperation Organization (SCO) with the signing of the memorandum of obligation at a summit in Samarkand, on 15-16 September. “This year, within Uzbekistan's chairmanship, Iran, as an observer state will ... become a full-fledged member of the SCO,” RIA Novosti quoted Uzbek Foreign Minister Vladimir Norov as saying yesterday during a meeting in Moscow. Iran took one step closer to full membership on 17 September last year when its application was accepted 15 years after it was made. On that date, SCO began the country's accession, which usually...

A bridge in Democratic Republic of Congo (DRC) collapsed as officials gathered to inaugurate it, according to local Khaama Press news agency. Videos of the accident are circulating on social media where people are mocking the construction quality. The small bridge was built to help locals cross a river during the rainy season. The temporary structure that was there before the bridge used to break frequently, the news agency said in its report. One of the videos shows officials standing on the bridge to formally inaugurate it during an official event. The inauguration would have been complete with the cutting...