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Metabolic Enzyme Promotes Neuroblastoma Aggressiveness High-risk neuroblastoma is an aggressive childhood cancer with poor treatment outcomes. Despite intensive chemotherapy and radiotherapy, less than 50 percent of these children survive for five years. While the genetics of human neuroblastoma have been extensively studied, actionable therapeutics are limited. Now researchers in the Feng lab at Boston University School of Medicine (BUSM), in collaboration with scientists in the Simon lab at the Perelman School of Medicine at the University of Pennsylvania (Penn), have not only discovered why this cancer is so aggressive but also reveal a promising therapeutic approach to treat these patients....

Coal use is surging in some of the world’s largest economies as electricity demand rebounds from the pandemic, illustrating the challenges to countries looking to wean themselves off the dirty but reliable fossil fuel. Coal was in decline for years in many countries, but its use is now picking up in the U.S., China and Europe despite growing pressure from governments, investors and environmentalists to curb carbon emissions. The leading reason for the uptick—which has pushed coal prices to multiyear highs—is rising power demand as economies reopen rapidly from pandemic hibernation. While analysts and executives say the resurgence of coal...

California's Oakland Zoo has vaccinated some of its larger animals against COVID-19, using a new experimental vaccine specifically formulated for animals.

This Independence Day, a poll from Issues & Insights revealed that only 36% of adults aged 18-24 said they were "proud to be American," compared with 86% of those over the age of 65. This shouldn't be surprising. America's children have been raised in a system dedicated to the proposition that America itself is evil, a repository of discrimination and bigotry, a country founded in sin and steeped in cruelty. This week, for example, the National Education Association, the single largest teachers union in the country, passed a resolution pledging to "Share and publicize ... information already available on critical...

MSNBC “Morning Joe” host Joe Scarborough on Wednesday had a message for President Donald Trump’s supporters: “America, love it or leave it.” Scarborough highlighted the shift from liberals hating everything about America to now “Trumpists” hating everything about the nation’s institutions that conservatives “were supposed to be protecting against the radical left.”

In New Hampshire, HB334 was passed by both the House and Senate, and should be sent to Governor Sununu in a few days. The conference committee report was adopted by both the House and the Senate on 24 June, 2021. HB 334 cleans up some leftover provisions from the Constitutional Carry bill passed by New Hampshire in 2017. There was a separate provision that banned the carry of loaded handguns on off-road vehicles and snowmobiles unless you had a concealed carry permit.With the passage of the Constitutional Carry, the provision no longer made any sense. HB334 eliminated that ban, as...

Governor Greg Abbott today issued a proclamation that identifies eleven agenda items for the Special Session that begins at 10:00 AM on Thursday, July 8. "The 87th Legislative Session was a monumental success for the people of Texas, but we have unfinished business to ensure that Texas remains the most exceptional state in America,” said Governor Abbott. "Two of my emergency items, along with other important legislation, did not make it to my desk during the regular session, and we have a responsibility to finish the job on behalf of all Texans. These Special Session priority items put the people...

I am amazed Yahoo reported this. Grievance politics seems to permeate every aspect of our society these days — and it has a serious cost. Robin DiAngelo and Ibram X. Kendi have emerged as contemporary televangelists. The deceptively-named concept of “anti-racism” is the new orthodoxy in our universities, and racial politics have also entered our public schools. Classics such as To Kill a Mockingbird and The Adventures of Huckleberry Finn are banned from some high school curricula, only to be replaced by woke bestsellers. As a Washington Examiner editorial chronicled, K-12 students have been subjected to “restorative justice” circles and...

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Republican Rep. Nancy Mace of South Carolina is standing her ground. Mace's house was vandalized over Memorial Day weekend. Since then, she goes about her business armed as police search for the culprit. "When they show up to your house, and physically just, you know, try to destroy it with graffiti, it's personal and it's invasive and it's violating, and it doesn't feel good," said Mace, according to Fox News. "I now go to the gun range almost weekly to practice shooting," she said. Mace warned anyone coming at her or her family in a June tweet.

An Oxford man convicted of sex trafficking is asking for a new trial, citing several trial errors — including one by a U.S. senator — that led to his conviction. William "Billy" Quinn, 57, filed a motion for a new trial Friday in Furnas County District Court. Quinn was found guilty of 13 counts of sexual assault and sex trafficking of a 15-year-old during a two-week trial last month in Beaver City. He was acquitted of one count of felony first-degree sexual assault. Quinn’s attorney, Joseph Howard of Omaha, filed the motion, alleging that, among other things, U.S. Sen. Ben...

As Jesus looked out to the end of the age, he pointed out a terrible problem. “He said to his disciples, ‘The harvest truly is plentiful, but the laborers are few.’” (Matthew 9:37, NKJV). As I read these words, I wonder, “What’s the solution? How can more laborers be raised up to go the nations?” Jesus gave the answer in the very next verse: “’Therefore pray the Lord of the harvest to send out laborers into his harvest.’” (Matthew 9:38). You may think, “Doors are closing all over the world.” That may be true, but it doesn’t matter how closed...

As we reported yesterday, White House Press Secretary Jen Psaki announced that they were going to be going “door to door” in an “outreach” to “get remaining Americans vaccinated.” Press Secretary Psaki says the US will implement “targeted community by community door-to-door outreach” to get more Americans vaccinated. pic.twitter.com/PcHdGX83NN — The Post Millennial (@TPostMillennial) July 6, 2021 Joe Biden then later repeated the same thing, showing it wasn’t a mistake or a random comment by Psaki. But there was more. She was asked if there was a target for herd immunity and if so, what that number would be. “What...

“Much more then, having now been justified by His blood, we shall be saved from the wrath of God through Him. For if while we were enemies, we were reconciled to God through the death of His Son, much more, having been reconciled, we shall be saved by His life” (Romans 5:9-10). Jesus Christ delivers His brethren not only from sin and its judgment, but also from uncertainty and doubt about that deliverance. God is a God of wrath. But the wrath due to be poured out on all mankind, Christ took on Himself. That’s what the apostle Paul meant...

During his Tuesday gun control speech, New York Gov. Andrew Cuomo (D) announced the re-instatement of a law designed to allow gun companies to be sued under the pretext of “public nuisance.” This puts New York on a collision course with the Protection of Lawful Commerce in Arms Act (PLCAA). Breitbart News noted Cuomo criticized the PLCAA, making clear he was going full steam ahead with efforts to counter it via the re-institution of New York’s Public Nuisance Liability for Gun Manufacturers. Cuomo described his goal as removing “immunity” for gun makers. Bloomberg Law notes Assemblywoman Patricia Fahy (D) believes...

DENVER (KDVR) — Single-use plastic bags and Styrofoam takeout containers will eventually be a thing of the past in Colorado after Gov. Jared Polis signed a bill to phase them out. The Plastic Pollution Reduction Act goes into full effect in 2024. Polis signed the law on Tuesday after Colorado Democrats passed the bill without any Republican support. The measure also repeals a pre-emptive law that bars local governments from passing stronger plastics restrictions than the state’s.

<p>Former President Donald Trump is expected to announce a class-action lawsuit Wednesday against three of the country's biggest tech companies: Facebook, Twitter and Google.</p><p>Trump will serve as the lead plaintiff in the suit, claiming he has been wrongfully censored by the companies, according to a person familiar with the action. The person spoke on condition of anonymity to share details ahead of the announcement.</p>

SEATTLE — A plea from Seattle Police Chief Adrian Diaz to put the guns down as the city and county see a spike in shootings. Concerned community leaders had a special meeting with the chief to address the wave of violent crime. “This last year and a half, I don’t see it slowing down,” Diaz said. It was a hard and honest conversation Tuesday evening at Emerald City Bible Fellowship Church. Diaz, the pastor and community advocates tried to find ways to curb the gun violence rocking the city and county. “I need those guns put down,” Diaz said. Even...

After their baby was born, the panicked father went to see the Obstetrician. 'Doctor,' the man said, 'I don't mind telling you, but I'm a little upset because my daughter has red hair. She can't possibly be mine!!' 'Nonsense,' the doctor said...'Even though you and your wife both have black hair, one of your ancestors may have contributed red hair to the gene pool.' 'It isn't possible,' the man insisted. 'This can't be, our families on both sides had jet-black hair for generations.' "Well, said the doctor, let me ask you this. How often do you have sex???" THE man...

The Biden administration came up short of its goal to have 70 percent of all adult Americans receive at least one COVID-19 vaccination by July 4. So on Tuesday it rolled out a new plan to take vaccination "door-to-door" and hopefully bolster flagging participation. But even as the White House worries of a virus resurgence because of the more contagious Delta variant of COVID, its latest plan isn't sitting well with many, particularly among conservative Republicans. Indeed, critics were quick to pan it as overly intrusive. "Now we need to go community to community, neighborhood by neighborhood, and oft-times door...