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... Remdesivir has been recently recognized as a promising antiviral drug against a wide array of RNA viruses (including SARS/MERS-CoV5) infection in cultured cells, mice and nonhuman primate (NHP) models. ..... Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c,...

It’s just the flu, bro. Normally experts in the field of epidemiology remind me of experts in global warming. But there is a professor who is both an MD and PhD in economics from Stanford who is a true Flubro. See link below: https://www.realclearpolitics.com/video/2020/04/02/dr_jay_bhattacharya_questioning_conventional_wisdom_in_the_covid-19_crisis.html There is a video at the link too.

At his coronavirus press conference on Saturday, April 4, President Donald Trump emphasized again that “we have to” restart business. But Allergy and Infectious Disease director Dr. Anthony Fauci has subtly if indirectly demurred on the possibility of such a restart. That puts Trump closer to virus checkmate than he realizes. He has moves, but they come from the misunderstood and misreported program of Swedish Voluntary Mitigation. Dr. Fauci remarkably states that America can restart as soon as there are no more deaths or even positive infections. The problem is that may never happen. The “social separation” of the CDC/NIH...

At the risk of upsetting a few folks, someone who appears to be in the know has tossed a small bucket of cold water on the notorious hydroxychloroquine and azithromycin drug cocktail: [....] First up is this study from France. It’s another very small one, and all the usual warnings apply because of that. It’s from a team at the University of Paris and Saint-Louis Hospital there, and they evaluated 11 consecutive patients admitted there with the same course of treatment as the Marseilles group first reported (hydroxychloroquine 600mg/day and azithromycin, 500mg the first day and 250 mg/day thereafter). The...

Gun Law Reform in Bolsonaro's Brazil, Homicides Drop Precipitously In December, 2018, in an article published by the Wall Street Journal, this pronouncement was made. From the wsj.com: Now, Brazil is set to embark on an experiment that will determine what happens when you loosen gun restrictions in a country battling an overpowering wave of gun crime. Homicides in Brazil were at historic highs in 2017. They dropped a bit in 2018, as candidate Bolsonaro ran on reform of the gun laws to allow self-defense, and reform of the law to get tough on crime.  The homicide numbers dropped from...

If you watch cable news, something I have assiduously avoided these past few weeks, you will be told that Barney Fife is in charge of the country, that the President lies, mismanages, exaggerates, and has totally botched America’s response to the coronavirus pandemic. Yet an honest observer sees much the opposite, rather than the fake news peddled by agents of doom in the media. Some say character is created in the crucible of adversity, yet the reality is that such adversity reveals character. Leaders are facing unprecedented challenges today, with lives and entire economies riding on every decision. Such battles...

It was a bloody Sunday in Trenton, as residents were supposed to be locked down in their homes because of the coronavirus outbreak. By 10 p.m., police were investigating five shootings that happened in a span of four hours throughout the city, ---SNIP--- Officials wondered if Gov. Phil Murphy's stay-at-home order may have contributed to pent-up rage among Trentonians cooped up in their houses due to the deadly coronavirus sweeping the state. "We lost our humanity," Mayor Reed Gusciora said by text message late Sunday. "May be retaliatory. And emotions have just boiled over today."

Among the works that first brought Henry Kissinger to academic acclaim was "A World Restored," his 1950s book about how the greatest diplomats of Europe met at the Congress of Vienna to restore order to a continent shattered by the Napoleonic Wars. The balance-of-power peace these men achieved lasted -- with the significant exception of the Franco-Prussian War of 1870-1871 -- for the full century, from 1815 to 1914. Writing in The Wall Street Journal Friday, Kissinger declared that it is now an imperative that the world's leaders, even as they deal with the raging pandemic, begin to make the...

The centuries-old premium Jewish communities place on religious gatherings is running headlong into the need for isolation amid the unyielding coronavirus pandemic. Like other religious institutions, Jewish communities around the country are attempting to adapt their traditions to government guidance designed to protect against the virus' spread, like holding online services and gatherings: virtual prayer in the wake of the current epidemic. But in and around New York, authorities complain that, far from discouraging gatherings, a few Orthodox Jewish leaders are leading prayer groups, celebrations and receptions that have been specifically prohibited by emergency orders in both New York and...

Maeve Kennedy Townsend McKean and her 8-year-old son drifted into the bay after paddling out in a canoe to retrieve a ball. Her body was recovered on Monday evening. The body of one of two Kennedy family members who went missing last week when their canoe capsized in the Chesapeake Bay was recovered on Monday, the authorities said. The Maryland Natural Resources Police said on Monday night that it had found the body of Maeve Kennedy Townsend McKean, 40, a granddaughter of Robert F. Kennedy. It said the search would continue for her son Gideon McKean, 8. Ms. McKean’s body...

Professor Klaus Püschel, head of forensic medicine in Hamburg, explains about Covid19: "This virus influences our lives in a completely excessive way. This is disproportionate to the danger posed by the virus.And the astronomical economic damage now being caused is not commensurate with the danger posed by the virus. I am convinced that the Corona mortality rate will not even show up as a peak in annual mortality." In Hamburg, for example, "not a single person who was not previously ill“ had died of the virus: "All those we have examined so far had cancer, a chronic lung disease, were...

A crew member on the Navy hospital ship sent to NYC to help with the coronavirus pandemic has tested positive for the illness, a report said on Monday night

BROTHERSVALLEY TOWNSHIP, Pennsylvania -- Anyone who drives along the narrow, winding township road just off of U.S. Route 219 immediately finds themselves whisked back in time, if only for a moment, as their car enters the Burkholder Bridge. The 150-year-old structure has cherry-red shingles; a charming sign bearing its name across the arc of the roof; and alabaster white sidewalls, which are distinctive because their openness allows much of the structure to be exposed. In theory, some would say this covered bridge has surpassed its usefulness in the modern world. Its 3-ton weight limit and 8-foot height limit restrict many...

Bloomberg News reports that the US intelligence community has concluded that China is “intentionally” hiding the true numbers of its coronavirus cases and fatalities — a fact that should surprise no one, and is yet another way Beijing has made the pandemic a bigger problem for the rest of the world. China reacted slowly but then effectively to the spread of the virus. It brought it under control, and the flu didn’t become the Chernobyl moment for China many foreign pundits predicted. But the bigger picture is that we should expect the spread of Communism after this crisis. Beijing is...

Thanks to Jonathan Karl for making my point for me. – I have repeatedly noted in recent weeks the fact that pretty much all of the big corporations who own all of the nation’s fake, corrupt news media outlets have been infected with ChiCom money and business interests just as America has been infected with the ChiCom-generated Wuhan Virus. As if to emphasize that point for me, ABC News’s Jonathan Karl, the current head of the White House Correspondents Association (WHCA) invited a “reporter” from a Hong Kong-based media operation that is in fact majority owned by ChiCom interests, including...

A statement widely attributed to the great British thinker G. K. Chesterton describes the modern period as perfectly as any single idea can: "When people stop believing in God, they don't believe in nothing; they believe in anything." One of these substitute gods has been nature. Indeed, of all the false gods, nature is probably the most natural for people to worship. Every religion prior to the Bible had nature-gods -- the sun, the moon, the sea, gods of fertility, gods of rain and so on. That is why the farther Western society gets from biblical, i.e., Judeo-Christian, religions, the...

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Comptroller Scott Stringer's mother, Arlene Stringer-Cuevas, 86, died on Friday after testing positive for coronavirus. During a Monday interview on CNN, Stringer blamed Trump for his mother's death. In New York City, this is playing out in so many families, and I’ve got to tell you, Donald Trump has blood on his hands, and he has my mom’s blood on his hands. And he sent us a hospital here in the Manhattan harbor, and no one can get on that hospital," Stringer said. "This is something that’s just outrageous, and so it’s very tough to mourn under these circumstances."

Three weeks ago Governor Gavin Newsom projected that 56% of California’s population — or 25.5 million people will be infected with the Wuhan Coronavirus over an 8-week period. Since we are nearly at the halfway point of Newsom’s prediction, we thought we would check in. As of Monday morning, California has 15,247 confirmed COVID-19 infections and 350 deaths — OUT OF about 40 MILLION PEOPLE! California is one of the largest economies in the world, yet the entire state has been virtually shut down because 0.04%. of the population has confirmed infections and 0.0009%. of the population has died from...

Half of us are going to come out of this quarantine as amazing cooks. The other half will come out with a drinking problem. •I used to spin that toilet paper like I was on Wheel of Fortune. Now I turn it like I'm cracking a safe. •I need to practice social-distancing from the refrigerator. •Still haven't decided where to go for Easter ----- The Living Room or The Bedroom •Every few days try your jeans on just to make sure they fit. Pajamas will have you believe all is well in the kingdom. •Homeschooling is going well. 2 students...