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In a major breakthrough, scientists have identified a rather elusive protein involved in the production of ‘good’ fat, brown fat, and found it can even boost the formation of these cells in white fat. Understanding how to ‘switch on’ the creation of this type of energy-burning cell opens the door to novel weight-loss treatments that have eluded researchers to date. Brown adipose tissue (BAT) is essential for producing heat from blood sugar and fat molecules, through a process called thermogenesis. It also requires a lot of energy (or calories) to fuel this. Unfortunately, by the time we reach adulthood, most...

fatcells A study by University of Alberta researchers has shown the fat cells that lie just beneath our skin shrink when exposed to the blue light emitted by the sun. “When the sun’s blue light wavelengths—the light we can see with our eye—penetrate our skin and reach the fat cells just beneath, lipid droplets reduce in size and are released out of the cell. In other words, our cells don’t store as much fat,” says Peter Light, PhD, senior author of the study, who is a professor of pharmacology and the director of UAlberta’s Alberta Diabetes Institute, in a release....

Fat people have less than thin people. Older people have less than younger people. Men have less than younger women. It is brown fat, actually brown in color, and its great appeal is that it burns calories like a furnace... --snip-- The brown fat also kept its subjects warm. The more brown fat a man had, the colder he could get before he started to shiver. Brown fat, Dr. Carpentier and Jan Nedergaard, Dr. Cannon’s husband, wrote in an accompanying editorial, “is on fire.” On average, Dr. Carpentier said, the brown fat burned about 250 calories over three hours. But...

Columbia University Medical Center (CUMC) researchers have identified a mechanism that can give energy-storing white fat some of the beneficial characteristics of energy-burning brown fat. The findings, based on studies of mice and of human fat tissue, could lead to new strategies for treating obesity and type 2 diabetes. The study was published August 2 in the online edition of the journal Cell. Humans have two types of fat tissue: white fat, which stores excess energy in the form of triglycerides, and brown fat, which is highly efficient at dissipating stored energy as heat. Newborns have a relative abundance of...

Scientists have discovered a biological switch that gives energy-storing white fat the characteristics of energy-burning brown fat. The findings could lead to new strategies for treating obesity. The animal study by researchers at The Ohio State University Medical Center shows that the change is due to the activation of a nerve and biochemical pathway that begins in the hypothalamus, an area of the brain involved in energy balance, and ends in white fat cells. This pathway, called the hypothalamic-adipocyte axis, also induces brown-fat-like cells within masses of white fat. The white-to-brown fat transformation occurs when animals are placed in an...

Scientists say they have found a way to turn body fat into a better type of fat that burns off calories and weight. The US Johns Hopkins team made the breakthrough in rats but believe the same could be done in humans, offering the hope of a new way to treat obesity. Modifying the expression of a protein linked to appetite not only reduced the animals' calorie intake and weight, but also transformed their fat composition. "Bad" white fat became "good" brown fat, Cell Metabolism journal reports. Brown fat is abundant in babies, which they use as a power source...