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Scientists have achieved a breakthrough in sepsis research. In a study on mice, the researchers demonstrated that vitamin B1 (thiamine pyrophosphate, TPP) restores mitochondrial energy metabolism, drastically reduces lactate production, and increases survival rates in sepsis. Sepsis is the body's runaway reaction to an infection. Instead of only attacking the pathogen, the immune system goes into overdrive and also attacks the body itself, while patients experience an excessive buildup of lactic acid in the blood. In the study, the research team has discovered a simple yet powerful therapeutic approach: a combination of vitamin B1 and glucose. In 2021, the same...

Cereals regarded as healthy may actually raise your risk of dementia — and it's not because of the sugar. A study published in the journal General Psychiatry found a link between a vitamin in brands such as Cheerios and Shreddies and cognitive decline, which can be a precursor for dementia. Thiamine, or vitamin B1, is also found naturally in whole grains, legumes, liver and salmon, and not getting enough of it has also been linked to health issues. But researchers say for the first time they've discovered a J-shaped curve that indicates consuming too much also has negative consequences.

Doses of vitamin B1 (thiamine) can reverse early kidney disease in people with type 2 diabetes, research shows. The team from Warwick University tested the effect of vitamin B1, which is found in meat, yeast and grain, on 40 patients from Pakistan. The treatment stopped the loss of a key protein in the urine, the journal Diabetologia reports. Charity Diabetes UK called the results "very promising" - but said it was too early for any firm conclusions.