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Keyword: squalenesynthase

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  • Cholesterol drug strips staph of color, virulence

    02/15/2008 12:35:11 PM PST · by Dysart · 25 replies · 167+ views
    Reuters via Yahoo ^ | 2-15-08 | Deena Beasley
    Potentially deadly staph bacteria may be easily defeated by the body's own immune system once stripped of their golden hue by a drug developed to lower cholesterol, according to new research.The findings offer a promising new direction in the fight against increasingly drug-resistant staph infections, according to the National Institutes of Health, which supported the research. An international team of researchers found that a "squalene synthase inhibitor," originally developed by Bristol Myers Squibb, blocks infections of Staphylococcus aureus, named for its "golden halo," in mice.Staph contains a carotenoid -- like beta carotene in carrots -- that acts like an antioxidant...