Researchers report a discovery in cardiac regeneration that offers new hope for the treatment of ischemic heart failure. The study reveals a novel approach to promoting cardiomyocyte proliferation. "When the heart cannot replace injured cardiomyocytes with healthy ones, it becomes progressively weaker, a condition leading to heart failure. In this study, we investigated a new way to stimulate cardiomyocyte proliferation to help the heart heal," said Dr. Riham Abouleisa. Previous studies showed that calcium plays an important role in cardiomyocyte proliferation. In the current study, Abouleisa and her colleagues explored how modulating calcium influx in cardiomyocytes would affect their proliferation....