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Keyword: p450

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  • Grapefruit Warning: It Can Interact with Common Medications

    07/21/2025 7:10:18 AM PDT · by Red Badger · 37 replies
    Healthline ^ | March 15, 2023 | Medically reviewed by Dena Westphalen, PharmD — Written by Matthew Thorpe, MD, PhD
    Grapefruit and its close relatives can increase the blood levels of certain drugs and cause serious side effects. Affected drugs include some medications for blood pressure and heart rhythm, among others. Grapefruit is a delicious citrus fruit with many health benefits. However, it can interact with some common medications, altering their effects on your body. If you’re curious about the grapefruit warning on many medicines, this article will help you understand why it’s there and what your options are. Here’s a closer look at 31 common drugs that may have dangerous interactions with grapefruit, as well as some alternatives. Note:...
  • Unlocking New Talents in Nature: Protein Engineers Create New Biocatalysts

    12/30/2012 1:17:16 PM PST · by neverdem · 5 replies
    ScienceDaily ^ | Dec. 20, 2012 | NA
    Protein engineers at the California Institute of Technology (Caltech) have tapped into a hidden talent of one of nature's most versatile catalysts. The enzyme cytochrome P450 is nature's premier oxidation catalyst -- a protein that typically promotes reactions that add oxygen atoms to other chemicals. Now the Caltech researchers have engineered new versions of the enzyme, unlocking its ability to drive a completely different and synthetically useful reaction that does not take place in nature. The new biocatalysts can be used to make natural products -- such as hormones, pheromones, and insecticides -- as well as pharmaceutical drugs, like antibiotics,...