Free Republic

Most Tuesdays, I run early in the morning with a woman named Meredith. For such close friends, we’re quite different. Meredith is a voluble social worker who draws energy from crowds. I’m an introverted editor who works from home. Meredith runs her best in large races and loves training with big groups. I’ve set PRs in solo time trials and tend to bail when a run’s head count gets above five. Meredith is a worrier, beset by regrets and anticipated outcomes, who has sought treatment for anxiety. I have dysthymia, or chronic low-grade depression. We like to joke that Meredith...

If you’re cruising along on a runner’s high while your partner has yet to feel that sweet euphoria, is that a nod toward your superior running ability? Sorry, no. The more likely reason could simply be in your genes, according to a recent study published in Medicine & Science in Sports & Exercise. Researchers looked at 25 collegiate runners, both male and female, and tested their saliva before and after a long-distance run. They also asked them about whether or not they experienced a runner’s high, which they gauged based on four criteria: mood, lost sense of time, run quality,...

US scientists have demonstrated the existence of undiscovered chemical pathways to an important class of bioactive lipids in the nervous system. Endocannabinoids are lipid messengers that play a key role in both central and peripheral tissues, where they participate in diverse physiological processes including appetite, pain-sensation, mood, and memory. Unlike other neurotransmitters such as amino acids and neuropeptides, they are not water soluble so cannot be stored in the body and are made on-demand from phospholipid precursors involving complex multiple pathways. A complete understanding of these mechanisms is crucial to understanding their effects in mammalian physiology, explains Benjamin Cravatt and Gabriel Simon at...