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Key Points Eli Lilly said its next-generation drug cleared a crucial late-stage trial in patients with obesity, delivering significant weight loss across doses. The results bring Lilly one step closer to filing for approval of the weekly injection, called retatrutide, which works differently from existing injections and pills. The highest dose of retatrutide helped patients lose 28.3% of their weight — or 70.3 pounds — on average over 80 weeks. ==================================================================== VIDEO AT LINK........ Eli Lilly on Thursday said its next-generation drug cleared a crucial late-stage trial in patients with obesity, delivering significant weight loss across doses. The results bring...

After decades of stigma, researchers are studying cannabis and its compounds like never before. As regulations and restrictions ease in many parts of the world, including the US, this controversial plant and its ancient health claims are finally being put to the test. For many years now, scientists have noticed that some cannabis users tend to have lower body weight and a reduced risk of developing type 2 diabetes compared to those who don't use cannabis. That is somewhat unexpected, as cannabis is known to trigger the 'munchies', or an appetite for food, in those who use the drug. Now,...

This innovative gel can be quickly applied to teeth in much the same way as standard fluoride treatments. Unlike traditional products, it contains no fluoride. Instead, it is made from proteins that imitate those naturally responsible for guiding enamel formation early in life.Once applied, the gel forms a thin yet durable layer that seeps into the surface of the teeth, filling in tiny cracks and holes. It then acts as a scaffold that captures calcium and phosphate ions from saliva. These minerals are carefully organized into new enamel through a process known as epitaxial mineralization. This allows the regenerated enamel...

Sen. Mark Warner (D-Va.) on Monday announced the death of his 36-year-old daughter, who had suffered from juvenile diabetes. “We are heartbroken beyond words by the passing of our beloved daughter, Madison, 36, after a decades-long battle with juvenile diabetes and other health issues. She filled our lives with love and laughter, and her absence leaves an immeasurable void,” Warner and his wife, Lisa Collins, posted in a statement on X. “We are grateful for the loving support of friends and family during this difficult time and ask for privacy as we navigate this profound loss,” he added. Madison is...

Doctors have found that metformin, an everyday medicine for diabetes, is associated with less progression of age-related macular degeneration (AMD), the most common cause of blindness in western countries. In a recent study, people with diabetes over the age of 55 years taking metformin were 37% less likely to develop the intermediate stage of AMD over a five-year period compared to those not taking metformin. AMD is a disease that affects the central retina or macular at the back of the eye. It eventually causes the light-sensitive tissue to die off (geographic atrophy, a form of dry AMD) or be...

Scientists have discovered that human stomach cells can be genetically reprogrammed to act like pancreatic beta cells and produce insulin. This approach could one day help people with Type 1 diabetes generate their own insulin without injections. Understanding Type 1 Diabetes and Its Challenges Type 1 diabetes develops when the pancreas fails to produce enough insulin, a hormone made by specialized beta cells. This chronic condition affects an estimated 9.5 million people around the world. Without sufficient insulin, blood sugar levels remain high and, over time, can cause serious harm to vital organs including the kidneys, eyes, and heart. Managing...

Novo Nordisk is the maker behind Ozempic and WegovyThe price of Novo Nordisk's blockbuster diabetes and weight loss-related drug Ozempic will be cut, according to President Donald Trump. Trump said this week during a White House event on fertility treatments and drug pricing the price reduction will come after swift negotiations with the drugmaker. "They'll be much lower," Trump told reporters. Novo Nordisk is the maker of Ozempic and Wegovy, which have the same active ingredient, semaglutide, but they are approved for different uses. Ozempic was approved by federal health officials in 2017 and marketed for medical use in the...

A study indicates that changes in the body that lead to type 2 diabetes occur long before current diagnostic thresholds for prediabetes are met. The study challenges conventional thinking about the onset of type 2 diabetes, identifying a risk category before prediabetes, called "pre-prediabetes." At this stage, people with normal glucose tolerance already have severe insulin resistance, early beta cell dysfunction and measurable cardiovascular disease. In this study, DeFronzo's team of scientists examined people with normal glucose tolerance, per ADA standards, and found that one measurement—one-hour glucose levels during an OGTT—is far better at predicting future disease. A value between...

In women with type 2 diabetes (T2D), use of hormone replacement therapy (HRT) skin patches is not associated with a higher risk of blood clots or stroke. However, an increased cardiovascular risk was found for oral HRT, according to a large real-world study. Among the findings are an analysis revealing women with T2D who took the oral form of HRT doubled their risk of developing a pulmonary embolism (PE—when a blood clot blocks an artery in the lung) and faced a 21% increased risk of heart disease compared with those receiving transdermal HRT (skin patches). "Our study suggests that up...

The wines named in the lawsuit are primarily inexpensive white or blush varietals including moscato, pinot grigio and sauvignon blanc.Many popular, inexpensive brands of wine made and distributed in California, including Trader Joe's famed "Two Buck Chuck," contain illegal and dangerously high levels of poisonous inorganic arsenic, according to a lawsuit filed Thursday in Los Angeles. Plaintiffs Doris Charles, Alvin Jones, Jason Peltier and Jennifer Peltier allege in their complaint that dozens of wineries are violating state law by knowingly producing, marketing and selling arsenic contaminated wine and failing to warn consumers about the potential danger. The suit, filed in...

Img src="https://scitechdaily.com/images/Marijuana-Leaf-Cannabis-Buds-Chocolate-Brownies-Edibles-777x518.jpg"> annabis use may secretly quadruple your risk of diabetes. Credit: Shutterstock Cannabis use may come with an unexpected cost: a nearly fourfold rise in diabetes risk. The finding, drawn from millions of health records, challenges assumptions about the drug’s effects and underscores the need for closer medical monitoring. Cannabis Use and Diabetes Risk Cannabis use has been associated with nearly a fourfold increase in the likelihood of developing diabetes, according to an analysis of health data from more than 4 million adults. The findings are being presented at this year’s Annual Meeting of The European Association for the...

The widely used diabetes drug metformin changes blood metal levels in humans. The study is an important step in understanding the drug's many actions and designing better ones in the future. Metformin is the most widely prescribed diabetes drug in the world. Apart from lowering blood sugar levels, it is also known to have a broad range of beneficial side effects such as against tumors, inflammation and atherosclerosis. However, although it has been used for more than 60 years now, its mechanism of action is still not clear, hampering the development of even better drugs against these conditions. Ogawa Wataru...

WASHINGTON (AP) — Global warming in the United States is amping up the country’s sweet tooth, a new study found.When the temperature rises, Americans — especially those with less money and education — drink lots more sugary beverages and a bit more frozen desserts. It amounts to more than 100 million pounds of added sugar (358 million kilograms) consumed in a year, compared to 15 years earlier, according to a team of researchers in the U.S. and United Kingdom writing in Monday’s Nature Climate Change.

Potatoes have long had a bad rap for being high in carbs. A new study backs that concern—at least in part.That weekly french fry habit could be setting you up for diabetes decades down the road. Research found that eating french fries just three times a week may significantly raise Type 2 diabetes (T2D) risk—but, surprisingly, other potato preparations showed no increased risk at all.RaraAvisPhoto/Shutterstock“Our findings suggest it’s not fair to put all potatoes in the same basket,” lead author Seyed Mohammad Mousavi told The Epoch Times.How You Like Your Potatoes MattersThe study, led by Harvard T.H. Chan School of...

Kidney complications in diabetes often progress silently, putting patients at risk of life-threatening outcomes long before any symptoms appear. A new study offers a promising solution. Researchers found that two simple blood markers—estimated glomerular filtration rate difference (eGFRdiff) and growth differentiation factor-15 (GDF-15) levels—can independently predict kidney disease progression and mortality in people with diabetes. "Currently, eGFR and urinary albumin, which are commonly used in routine clinical practice, are not sufficient to accurately predict kidney outcomes in individuals with diabetes," says Dr. Gohda. The research team analyzed data from 638 Japanese adults living with diabetes mellitus. Participants were observed for...

A study has found that drinking just one can of artificially-sweetened soft drink a day may increase the risk of developing type 2 diabetes by 38%. Surprisingly, that risk for artificially sweetened soft drink is even higher than for those who consume sugar-sweetened beverages, such as regular soft drinks, where the risk was found to be 23% higher. The research followed more than 36,000 Australian adults over nearly 14 years. The study—led by Professor Barbora de Courten, Associate Professor Allison Hodge, and Ph.D. student Robel Hussen Kabthymer—adds to growing global concern about the health effects of both sugary and artificially...

A team has identified a potential new strategy to prevent, and even reverse, immune checkpoint inhibitor–induced type 1 diabetes, a rare but life-threatening side effect of cancer immunotherapy, using an existing class of autoimmune drugs. The study identifies a new group of immune cells involved in the development of immune checkpoint inhibitor–induced type 1 diabetes and shows that JAK inhibitors, which are already FDA-approved for conditions like psoriasis and arthritis, can stop the autoimmune attack on insulin-producing cells in the pancreas and, in some cases, even reverse the damage in preclinical models. Checkpoint inhibitors like pembrolizumab and nivolumab have revolutionized...

It’s no secret that kids (and some of us adults) love fruit juice. Many of us grew up drinking fruit juice, and parents often think 100% fruit juice is healthy. But is it really? UC Davis Health pediatricians Lena Rothstein and Dean Blumberg tackled this juicy topic in their podcast Kids Considered: We often like the taste of fruit juice because it’s a sweet drink. But it’s no secret that sweet often means more sugar, even if it’s natural sugar. Think about whole fruits that are sweeter – they have more natural sugars that make them taste sweet. Same goes...

The health benefits of potatoes are misunderstood, according to research by professor Neda Akhavan in UNLV’s Department of Kinesiology and Nutrition Sciences. Nutrition sciences professor Neda Akhavan’s recent research identifies potatoes as a potential superfood for individuals with Type 2 diabetes. New research reveals that properly prepared potatoes can offer significant health benefits, including cardiovascular improvements, for people with Type 2 diabetes, challenging their negative dietary reputation. The potato is small enough to fit inside a person’s hand yet contains enough nutrients to whittle waistlines and lower blood sugar in adults with Type 2 diabetes. Yet, despite the fact that...

Despite medical advances, infectious diseases caused by bacteria and viruses are still among the most common causes of death worldwide. What role could fructose play in such diseases? A research group has now been able to prove for the first time that monocytes, important immune cells in the blood, react more strongly to bacterial toxins after fructose consumption—but not in a positive way. Specifically, the concentration of receptors for certain bacterial toxins increases, making the body more susceptible to inflammation. In two independent randomized studies with healthy adults, the researchers investigated how the consumption of fructose-sweetened beverages affects the immune...