Posted on 03/05/2025 7:20:41 PM PST by ConservativeMind
A study suggests that fish oil can weaken insulin resistance and reduce glucose intolerance by modulating the body's inflammatory response.
The findings were based on experiments with rats, which were not obese but exhibited a condition similar to type 2 diabetes, a disease characterized by elevated blood sugar due to reduced action of the hormone insulin.
As the authors explain, supplementation with omega-3 fatty acids such as those present in fish oil has been prescribed for individuals with cardiovascular problems and type 2 diabetes, but the effects of these nutrients on insulin resistance without obesity are poorly understood.
In this study, the researchers observed that administration of 2 grams of fish oil per kilogram of body weight (equivalent to 540 mg/g of eicosapentaenoic acid, or EPA, and 100 mg/g of docosahexaenoic acid, or DHA) three times per week for eight weeks reduced insulin resistance in non-obese rats, which also displayed improved levels of blood sugar, inflammatory markers and lipid features, including total cholesterol, LDL ("bad cholesterol") and triglycerides.
The researchers reported an early breakdown of anti-inflammatory mechanisms in non-obese GK rats with insulin resistance. Lymph nodes (part of the immune system) in newly weaned 21-day-old GK pups already exhibited a reduction in markers of regulatory T-cells (Tregs, cells with anti-inflammatory characteristics). Other early inflammatory alterations were also observed in the rats.
"Fish oil supplementation reversed this pro-inflammatory profile, displaying a significant anti-inflammatory effect and reducing polarization of Th1 and Th17 cells [lymphocyte subtypes that perform crucial functions in inflammation], followed by a rise in the percentage of Tregs, which can inhibit the activation of pro-inflammatory lymphocytes. Thus the action of omega-3 fatty acids on lymphocytes, modulating them from a pro-inflammatory state to an anti-inflammatory state, may have triggered the reduction in insulin resistance in these animals," Lobato said.
(Excerpt) Read more at medicalxpress.com ...
Bkmk
3 negatives=positive? U tell me.
I read that fish oil can reduce insulin resistance. But it requires you to like fish.
It amazes me how the medical industry can study the hell out of what effects rats,but they pumped untested poison into millions of humans. That resulted in hundreds of thousands of deaths,and they don’t even acknowledge it. I have lost all faith in the medical industry. They have completely failed us.
“2 grams of fish oil per kilogram of body weight”
For a 160 pound guy, that’s about 145 grams of fish oil. That is 145/225 times an 8 oz cup, so about 5 oz of fish oil taken 3 times a week.
Any volunteers? I thought not.
That was just to force the mice to show the cells that benefited.
The article mentions earlier that a couple grams of fish oil is prescribed to patients knowing it helps, but never understanding the why.
“A study suggests that fish oil can weaken insulin resistance and reduce glucose intolerance by modulating the body’s inflammatory response.”
After reading a statement like that then I realize how little I know. Very confusing.
Been taking the stuff for years...hasn’t helped a lick.
One could argue it could be worse but, then, you would never know.
Burp! I can’t afford that much fish oil!
I take a low dose of fish supplement every other day. I’m never constipated. Coincidence?
We will develop the healthiest and strongest mice and rats on Earth...................
We will develop the healthiest and strongest mice and rats on Earth...................
I read that fish oil can reduce insulin resistance. But it requires you to like fish.It also requires that you not have shellfish allergies. 😟
“That was just to force the mice to show the cells that benefited.”
When you increase something to that extent, you probably are creating effects that do not exist at the much lower dose. I supplement with liquid fish oil - lemon flavor - 2-3 teaspoons a day. I don’t know if it helps.
Studies on fish oil capsules mostly show no benefit at all.
But if you increase a dose from 2 teaspoons to 5 ounces, you are testing something entirely different. Add in the tests are in mice - primarily herbivores with a different digestion system than we have - and you end up with a meaningless result. Which, unhappily, describes most nutrition studies.
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