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Antioxidants (Basel). 2020 Jul; 9(7): 624.Published online 2020 Jul 16. doi: 10.3390/antiox9070624PMCID: PMC7402141PMID: 32708578Francesca Silvagno,* Annamaria Vernone, and Gian Piero PescarmonaAuthor information Article notes Copyright and License information DisclaimerThis article has been cited by other articles in PMC. Go to:AbstractThe novel COVID-19 pandemic is affecting the world’s population differently: mostly in the presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal cytokine storm and patients die from acute respiratory distress syndrome, whereas in many cases the disease has a mild or even asymptomatic progression. A common denominator in all conditions associated with COVID-19 appears...

Paris (AFP) - Dozens of scientists have raised concerns over a large-scale study of hydroxychloroquine and chloroquine published in the Lancet that led to the World Health Organization suspending clinical trials of the anti-viral drugs as a potential treatment for COVID-19. Hydroxychloroquine, normally used to treat arthritis, has become one of the most high profile drugs being tested for use against the new coronavirus. This is partly because of comments by public figures including US President Donald Trump, who announced this month he was taking the drug as a preventative measure. In research published in the Lancet on May 22,...

The use of Real World Evidence in Covid-19 is growing, and that’s a good thing. Properly implemented, RWE has the potential to deliver solid results faster than Randomized Controlled Trials, as I explained in a .css-mckguv{-webkit-transition:background 0.25s var(--ease-in-out-quad),color 0.25s var(--ease-in-out-quad);transition:background 0.25s var(--ease-in-out-quad),color 0.25s var(--ease-in-out-quad);color:var(--theme-ui-colors-accent,#6166DC);}.css-mckguv:visited{color:var(--theme-ui-colors-accent,#6166DC);opacity:0.85;}.css-mckguv:hover,.css-mckguv:focus{-webkit-text-decoration:underline;text-decoration:underline;}previous blog post.So I couldn’t miss the largest observational study published to date on the effects of (hydroxy-)chloroquine, in 96 032 hospitalised Covid-19 patients, from an international registry comprising 671 hospitals in six continents:Mehra, M. R., Desai, S. S., Ruschitzka, F., & Patel, A. N. (2020). ‘Hydroxychloroquine or chloroquine with or without a macrolide for treatment of...

ABSTRACT Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to...

RIO DE JANEIRO (Reuters) - Brazil’s Health Ministry will issue new guidelines on Wednesday expanding the recommended use of chloroquine for treating the novel coronavirus, President Jair Bolsonaro said, days after the health minister quit under pressure to sign the new guidelines. Interim Health Minister Eduardo Pazuello, an active duty army general, will sign the new protocol and stay in the top job for now, the president said in an online interview on Tuesday evening. Bolsonaro said he kept a box of the anti-malarial drug in case his 93-year-old mother needed it, noting U.S. President Donald Trump said he was...

COVID-19: Hydroxychloroquine, Chloroquine, and Azithromycin Posted on April 13, 2020 ***This page is being continuously updated as we collect more information. Please excuse any formatting challenges for the time being. If you have other info to add, please let us know in the comment box below!The chart below includes NASPA’s compilation of state actions affecting Hydroxychloroquine, Chloroquine, and Azithromycin. This is a work in progress.The following are other relevant links: FDA Fact Sheet for Emergency Use Authorization from the Strategic National StockpileFDA Request for Emergency Use Authorization from the Strategic National StockpileFDA Cautions Against Use of Hydroxychloroquine or Chloroquine...

Introduction We are currently facing a pandemic involving a newly discovered coronavirus (SARS-CoV-2) which putting our societies to the test in many ways. Despite controversy, only two drugs, namely hydroxychloroquine (HCQ) and chloroquine (CQ), have been used by physicians on a large-scale basis as treatment forCOVID-19 [1]. According to the Sermo Real Time Covid-19 Barometer (https://www.sermo.com/, consulted 20 April), for over 20,000 physicians across 30 countries, chloroquine derivatives are the first medication used to treat COVID-19 patients in ICUs (67%), the second medication in other hospital settings (66%),and the third in outpatient settings (40%). While many countries recommend it for...

The Mesa City Police Department's homicide division is investigating the death of Gary Lenius, the Arizona man whose wife served him soda mixed with fish tank cleaner in what she claimed was a bid to fend off the coronavirus. A detective handling the case confirmed the investigation to the Washington Free Beacon on Tuesday after requesting a recording of the Free Beacon's interviews with Lenius's wife, Wanda. Gary Lenius, 68, died on March 22. Wanda, 61, told several news outlets last month that both she and her husband had ingested a substance used to clean aquariums after hearing President Donald...

In death, he has become famous as a cautionary tale about the risks of mindlessly following the armchair medical advice President Donald Trump has dispensed from the White House podium. But friends of 68-year-old Gary Lenius, the Arizona man who passed away last month from drinking a fish tank cleaner that contained an ingredient, chloroquine phosphate, that Trump had touted as a potential coronavirus cure, say they are still struggling to understand what drove an engineer with an extensive science background to do something so wildly out of character.

Introduction: The first-line therapy for the intermittent preventive treatment of malaria in pregnancy (IPTp) is sulphadoxine-pyrimethamine (SP). There is an urgent need to identify safe, well-tolerated and efficacious alternatives to SP due to widespread Plasmodium falciparum resistance. Combination therapy using azithromycin and chloroquine is one possibility that has demonstrated adequate parasitological response > 95% in clinical trials of non-pregnant adults in sub-Saharan Africa and where IPTp is a government policy in 33 countries. Areas covered: Key safety, tolerability and efficacy data are presented for azithromycin and chloroquine, alone and/or in combination, when used to prevent and/or treat P. falciparum, P....

The Communist Democrats, NWO freaks, and the media are trying to kill us. On Wednesday March 25, 2020 I was supposed to have dinner with First Lady Melania Trump and a number of fellow women fundraisers, at Mar-a-Lago, Palm Beach, Florida. On that morning I awoke in Washington, DC with flu symptoms. This is the story of that journey – and I promise you – a truthful report of what is really going on out there with this pandemic and how politics is responsible for the damage to the U.S. economy and for the unnecessary deaths of Americans. Day 2:...

Doctors who prescribe an anti-malarial drug being touted as a potential COVID-19 treatment will face a $13,000 fine due to new prescription rules. The rules, brought into effect in Queensland on Tuesday, means that clinicians are banned from prescribing hydroxychloroquine as a COVID-19 treatment. Hydroxychloroquine is an anti-malarial drug now used to treat anti-immune conditions such as lupus and rheumatoid arthritis. There is no solid evidence that the drug is effective against COVID-19, but Federal Health Minister said that there has been “some promising research so far”. The new restrictions were brought in place after doctors began prescribing the drug...

Israeli Prime Minister Benjamin Netanyahu on Thursday thanked his Indian counterpart Narendra Modi for rushing a five-tonne cargo of medicines, including anti-malarial drug hydroxychloroquine, seen as a possible cure for COVID-19. "Thank you, my dear friend @narendramodi, Prime Minister of India, for sending Chloroquine to Israel. All the citizens of Israel thank you!", Netanyahu said in a tweet Thursday evening. The Israeli’s PM’s thanked India two days after a plane carrying materials used to make medicines for treating coronavirus patients arrived in Israel from India on Tuesday. The five tonne shipment included ingredients for drugs chloroquine and hydroxychloroquine, being seen...

President Emmanuel Macron on Thursday held a surprise meeting with the Marseille-based French medical professor who has caused controversy within the country’s scientific community for insisting the anti-malaria drug chloroquine can beat the coronavirus. Professor Didier Raoult met Macron at his specialised infectious diseases hospital in Marseille, in a visit that was not announced in advance, the French presidency said. The meeting lasted three and a half hours and, unusually, media were allowed no access. The findings of Raoult, a prominent figure in France, have divided opinion, with some hailing him as a savior but others deriding his work as...

Several hospitals in Sweden have reportedly stopped administering chloroquine to coronavirus patients following reports the drug was causing adverse side effects. According to the national paper Expressen, hospitals in the Västra Götaland region are no longer offering the antimalarial medication, with side effects reported to include cramps and the loss of peripheral vision. One of the patients affected was Carl Sydenhag, a 40-year-old Stockholm resident. According to Expressen, Sydenhag was prescribed two tablets of chloroquine to take daily after he was diagnosed with COVID-19 on March 23. But instead of making him feel better, the medication produced unpleasant side effects....

For hospitalized patients with COVID‐19 who have evidence of pneumonia, we suggest hydroxychloroquine (or chloroquine) on a case‐by‐case basis. Requirements include all of the following: a) shared decision‐making in which the patient is informed about the possible benefits and potential side effects, b) collection of data in a manner that enables studies that use valid methods for causal inference and control of confounders for the purpose of interim assessment, c) the patient’s clinical condition is sufficiently severe to warrant investigational therapy, and d) there is not a shortage of drug supply. 73% for intervention, 16% no suggestion, and 11% against...

... Remdesivir has been recently recognized as a promising antiviral drug against a wide array of RNA viruses (including SARS/MERS-CoV5) infection in cultured cells, mice and nonhuman primate (NHP) models. ..... Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c,...

In the past 24 hours, hydroxychloroquine (HCQ) has been making news again. US President Donald Trump has once again promoted the use of this drug as a cure for the Coronavirus, or COVID-19. The US has also reached out to India to lift the ban on hydroxychloroquine exports, which India had imposed on March 26. It is not just Trump and the US who want India to lift restrictions on exports of what is believed to be the miracle drug to cure Coronavirus. Brazilian President Jair Bolsonaro, among other state leaders, is also believed to have reached out to the...

New York Gov. Andrew Cuomo (D) said Monday that early responses to the antimalarial drug hydroxychloroquine “anecdotally” suggest its use in the coronavirus fight has been “effective,” but that official data was still forthcoming. Asked about the progress of the trials at his daily press briefing, Cuomo noted that state officials have allowed use of the drug in combination with the antibiotic Zithromax in hospitals “at their discretion.” He said the federal government would increase supplies to New York pharmacies, but that New York has imposed a 14-day limit to protect the supplies for people who rely on it to...

America’s major medical society specializing in the treatment of respiratory diseases has endorsed using hydroxychloroquine for seriously ill hospitalized coronavirus patients. The American Thoracic Society issued guidelines Monday that suggest COVID-19 patients with pneumonia get doses of the anti-malaria drug. “To prescribe hydroxychloroquine (or chloroquine) to hospitalized patients with COVID-19 pneumonia if all of the following apply: a) shared decision-making is possible, b) data can be collected for interim comparisons of patients who received hydroxychloroquine (or chloroquine) versus those who did not, c) the illness is sufficiently severe to warrant investigational therapy, and d) the drug is not in short...