Tufts University researchers have identified a gene-diet interaction that appears to influence body weight and have replicated their findings in three independent studies. Men and women carrying the CC genotype demonstrated higher body mass index (BMI) scores and a higher incidence of obesity, but only if they consumed a diet high in saturated fat. These associations were seen in the apolipoprotein A-II gene (APOA2) promoter. "We believe this is the first time a gene-diet interaction influencing BMI and obesity has been replicated in as many as three independent study populations," says corresponding and senior author Jose Ordovas, PhD, director of...