Posted on 11/10/2019 3:06:54 AM PST by tired&retired
For the first time, a study shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course of 24 hours.
The research conducted in mice found that the time-of-day dependent metabolic cycle is altered by high caloric diet. Since glucocorticoids are widely used drugs for the treatment of inflammatory diseases, these findings published in Molecular Cell suggest that lean and obese patients might respond differently to steroid therapy. Finally, it reveals the biological function of daily rhythms of hormone secretion (high before awakening and feeding, low when sleeping and fasting) as well as daily cycles of sugar and fat storage or release by the liver.
Each cell in the human body is driven by an internal clock which follows the circadian rhythm of 24 hours. It is synchronized with the natural cycle of day and night mainly by sunlight, but also through social habits. In a healthy system, glucocorticoid stress hormones, are produced every morning by the adrenal gland.
The secretion of glucocorticoidpeaks before awakening, prompting the body to use fatty acids and sugar as sources of energy, and enabling us to start our daily activities. When the circadian rhythm is disrupted (e.g. through shift work or jetlag) and/or when the glucocorticoid level alters (e.g. through Cushing syndrome or long-term clinical application), profound metabolic dysregulation can be caused -- like obesity, type 2 diabetes, and fatty liver disease. The researcher's goal therefore was to understand the relevance of these daily peaks of stress hormone secretion, the impact of these hormones on our "internal clock" and their role for daily cycles of metabolism.
(Excerpt) Read more at sciencedaily.com ...
This could be the reason people with sleep apnea become obese.
Nah I was obese before I got sleep apnea and lost 120 pound while I had sleep apnea :)
People who eat too much become obese. People who eat less than their required calorie lose weight.
I know firsthand :)
There were NO overweight people in holocaust camps, regardless of whether they had sleep apnea or a defective thyroid or a gland affectation or whatever.
The true horror is they starved.
The reality for 99.99 percent of overweight people is they eat too much.
Im still fat lol. Just 120 pounds LESS FAT :)
And not eating for a period, fasting, is NOT starvation.
After day 1 of fasting, maybe 16 or 20 hours, the body burns pure fat. It is remarkable.
From day 2 onward, you are losing 2 pounds of fat per day. With an accurate gravity scale, you can see the loss. One week of fasting, resets the body.
The best diet occurs day 2 onward. As long as you can go.
Two pounds of fat a day, is the body equivalent energy needed to live.
It is amazing really.
I did my FIRST 3 day fast this past May.
I haven’t felt THAT GOOD afterwards since my 20s.
I did three 3 day fasts in May and June and for the first time in maybe TWENTY YEARS my cholesterol and triglycerides were normal.
My fasting glucose went to 85 from 93.
Simply amazing.
It wasn’t easy. It WAS worth it.
Have kept the weight off but NEED to get in the mindset to do it again.
I’m a stress eater. And WOW can I stress eat!!
A prayer for your future success in weight control. Mine too.
You’re generally correct, except it would take something like a serious endurance athlete in training to burn off that much a day. When you deplete your body of carbs as you describe, there is also a fairly quick drop in water retained in the body. That contributes to, though doesn’t fully cover, why the body appears to be losing so much more wait at the initiation of a fasting, keto or similar diet.
Congratulations on your success.
Ketones serve as fuel for the mitochondria to make ATP for fuel in the body without creating the carbon dioxide byproduct when glucose is used.
This process is called the Krebs Cycle or citric acid cycle. It’s an aerobic process that is 7 times more efficient than the anaerobic ATP production in the cytoplasm.
Studies have shown that ketosis reduces hypoxia in the body by decreasing CO2 levels. They found it greatly increased the time free divers could hold their breath under water.
This is part of the cause for the ketone energy high.
Fasting is a challenge. But it is good for the immune system and other things. As for weight loss: the most important thing is sleep. 5.5 hours or less really slows the calorie consumption by the body.
“This could be the reason people with sleep apnea become obese.”
I’m pretty sure that’s the other way around.
I have already seen some detractors, but in general, many people who have undiagnosed sleep apnea gain weight. I know of more than one person who reversed weight gain once they got a cpap machine and could sleep better.
Personally, if I go to bed on time and engage in about 30 minutes of exercise everyday (which helps me sleep), my diet is different. I am not nearly as hungry and have very few food cravings. If I have less sleep, there isn’t a drive through I can pass by, bag of chips or soda I can’t pass up. Kettle corn becomes a food group. On top of that my body probably isn’t processing these foods as well as if I had rest.
BobL...please ping the group.
I know first hand that prednisone drastically increases blood sugar.
“From day 2 onward, you are losing 2 pounds of fat per day. With an accurate gravity scale, you can see the loss. One week of fasting, resets the body.
The best diet occurs day 2 onward. As long as you can go.
Two pounds of fat a day, is the body equivalent energy needed to live.”
Sorry, but 2 pounds of fat per day isn’t right, except maybe for marathon trainers and people like them. There’s a lot of energy in fat (roughly 3500 calories), so it comes out to about 2/3’s of a pound per day (with people burning 2300 calories per day). So to lose 2 pounds of fat, you need 3 days of complete fasting...unless you do have exercise. For example, walk 12 miles per day while fasting, and you’ll reach one pound of fat burning per day (walking is roughly 100 calories per mile). To get to 2 pounds, you’ll need to walk another 35 miles, which isn’t possible, for most of us at least.
And trust me, the numbers above are good for most men other than severely overweight, at least related to non-exercise part. I’ve been able to predict my weight virtually to the pound 2 months out using them...with many fasts, and the factors above can also be found by simple searches.
Thanks for the ping Ftr!
LOW CARB / KETO PING!!!
[p.s., anyone wanting to join, or leave, my Low-Carb ping list, just let me know, privately or publicly]
Interesting about CO2 and the divers’ breathing, thanks.
There are 100’s of sites for Keto. Here is one https://www.dietdoctor.com/
Also there are over 1.6+ MILLION people doing Keto here: https://www.reddit.com/r/keto/
When i first started paleo i lost lotsa weight, when i started IF the next plateau shattered and i lost weight i thought was permanent.
At that point i decided to go for another goal and fasted 24 to 36 hours followed by a giant 5 to 6000 calorie high fat meal over the course of 2 hours and back to fasting. That combined with lots of movement and heavy lifting, body weight exercises, and a 5 to 8 hour hard hike/climb every week got me down to a ripped 160 lbs
I am certain however that the fasting and carb avoidance was 90% of the weight loss
Felt great but life gets in way and its not easy to maintain that lifestyle
“There are 100’s of sites for Keto. Here is one https://www.dietdoctor.com/
Also there are over 1.6+ MILLION people doing Keto here: https://www.reddit.com/r/keto/
“
...and yet Wikipedia dedicates a whole 5 sentences to the Ketogenic Diet (as a weight loss method), with 4 of them negative. Plus they have their article on full lockdown, which is very rare.
I point that out to show that there is a coordinated and sustained effort to marginalize and trash the entire concept of going low-carb, and literally zero interest in debating it - pretty much the same thing we see regarding Global Warming.
As you suggest, there a bundle of sites that mock Keto. However I believe the arguments need to be flipped around. Dietitians/nutritionist/doctors that still recommend the food pyramid...are recommending an obesity outcome to 40% of the people.
They can’t defend their recommendations. Instead they poop all over Keto.
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