In a Nutshell * An oral compound called TOFA caused significant weight and fat loss in obese mice without reducing food intake or causing muscle loss, setting it apart from current obesity drugs. * TOFA worked by boosting how much energy cells burn, rather than suppressing appetite, and it also improved blood sugar, harmful blood fats, and fatty liver disease. * When combined with semaglutide or tirzepatide, TOFA outperformed either drug alone, and animals maintained their weight loss longer after TOFA treatment ended compared to semaglutide. ============================================================================================== Millions of Americans struggling with obesity have placed their hopes in a new...