Heart failure is often identified only when the heart has already deteriorated. This is in large part because the cause is unknown for about 70% of people who experience heart failure. Researchers have discovered that one of the earliest signs of heart failure is a change in how the heart produces energy, with findings offering a potential way to preempt heart failure before the heart begins to deteriorate. Led by Dr. Paul Delgado-Olguín, the research may help explain the diversity of causes underlying heart failure. "We were surprised to find that dysregulation of energy production was the earliest sign of...