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A group of international researchers has uncovered evidence of a super rare genetic condition that gives men an extra X chromosome, reporting the oldest clinical case of Klinefelter Syndrome to date.The evidence comes from a 1,000-year-old skeleton from Portugal.Klinefelter Syndrome is a rare genetic condition where individuals are born with an extra copy of the X chromosome, occurring in approximately one in 1,000 genetic-male births...The team began by analysing genetic information obtained from a skeleton found in northeastern Portugal that had been radiocarbon dated to the 11th century by researchers from the University of Coimbra in Portugal...The researchers say the...

As many as one in 500 men may carry an extra sex chromosome — either an X or a Y — but very few of them likely know about it...The research, published June 9 in the journal Genetics in Medicine(opens in new tab), included data from more than 207,000 men who provided information to the U.K. Biobank, a repository of genetic and health data from half a million U.K.-based participants. Typically, males carry one X- and one Y-shaped sex chromosome in each of their cells, but among the study participants, there were 213 men who carried an extra X chromosome...

Each year in the United States, about 150,000 babies are born with birth defects ranging from mild to life threatening. While progress has been made in the detection and treatment of birth defects, they remain the leading cause of death in the first year of life. Birth defects are often the result of genetic and environmental factors, but the causes of well over half of all birth defects are currently unknown. Following is a partial list of birth defects: Achondroplasia/Dwarfism Hemochromatosis Alpha-1 Antitrypsin Deficiency Huntington's Disease Anencephaly Hydrocephalus Arnold-Chiari Malformation Klinefelter's Syndrome Ataxia Telangiectasia Leukodystrophies Blood coagulation disorders/Hemophilia Marfan Syndrome...

A Harvard-educated Texas Democratic lawmaker drew double-takes for declaring at a hearing that there are six sexes, prompting a rebuke from skeptics who said his count was off by four. Texas state Rep. James Talarico made his pronouncement prior to public testimony Tuesday before the Public Education Committee on House Bill 4042, a measure to bar transgender athletes from girls’ K-12 scholastic sports. Mr. Talarico, a former English teacher, first quizzed Republican state Rep. Cole Hefner, the bill’s sponsor, on how many sexes there are. Mr. Hefner said there were two. “The bill seems to think there are two,” said...