Simple treatment can save lives for men with a common chromosomal disorder

Medical Xpress / Aarhus University / The Lancet Regional Health—Europe ^ | Feb. 13, 2025 | Simon Chang et al

[ConservativeMind]

More than half of all men with Klinefelter syndrome (KS) are unaware that they have the condition. Among those who do receive a diagnosis, only about half get the treatment they need.

Now, a Danish study reveals that testosterone treatment not only improves quality of life—it can also save lives.

Klinefelter syndrome is the most common sex chromosome disorder in men, affecting approximately one in 600 male births.

The condition results from being born with an extra X chromosome, leading to low testosterone production, which in turn increases the risk of cardiovascular disease, type 2 diabetes, and overall higher mortality rates.

This is the first study of its kind and shows testosterone treatment nearly halves the mortality rate among men with KS.

Male participants who received treatment lived significantly longer than untreated men, with their mortality rate approaching that of the general population.

Researchers cannot yet fully explain why the treatment leads to such a significant reduction in mortality.

According to Simon Chang, the effect may be linked to improved metabolism, increased muscle mass, and reduced body fat as a result of testosterone therapy.

"Testosterone is a powerful hormone that affects nearly every function in the body. We also suspect that it may have positive effects on the immune system, bone health, and possibly even cognitive functions," he explains.

The study, he adds, underscores the importance of identifying more men with KS who remain undiagnosed. More than half of those born with KS are never diagnosed, even though a simple screening test at birth could identify the syndrome through the routine blood sample taken from all newborns.

The study confirms that testosterone therapy does not increase the risk of serious cardiovascular diseases, heart attacks, or strokes.

However, there is a slightly increased risk of heart failure among men receiving treatment.

[ConservativeMind]

Simply giving testosterone to these men with an extra X chromosome makes them live and think like normal men.

Without it, they die rather earlier and experience multiple other issues.

[ConservativeMind]

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[fwdude]

The are the men that the left claims are “transgender,” “non-binary,” of “gender non-conforming.” It is enough for them to claim genital mutilation as the remedy, even in children.

[teeman8r]

XY IS the chromosomal disorder.

[fishtank]

I don’t understand this comment.

[teeman8r]

let me mansplain to you...

XX good

XY not as good as XX

[fishtank]

I couldn’t tell if you were being sarcastic or not.

Thanks!!

[CodeJockey]

I can only imagine the chaos going to your doc and asking for a diagnosis to determine if you are XX or XY. Sounds like something insurance would not cover.