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Researchers have discovered early signs of clinical benefit while testing niraparib, a PARP inhibitor, in patients with advanced melanoma whose tumors had specific genetic changes impacting DNA repair. The single-arm, investigator-initiated phase II trial examined the effectiveness of niraparib in a select group of patients whose disease previously progressed after standard treatment such as immunotherapy, and BRAF/MEK-targeted therapies. The U.S. FDA approved tumor-infiltrating lymphocyte therapy for advanced melanoma in patients who have previously received anti-programmed cell death 1 (PD-1) antibody therapy, and if their tumors are V600 BRAF-mutant, a combination of BRAF and MEK inhibitors. "Despite these available, approved combination...

The suicide of a 26-year-old Pennsylvania police officer over the aftereffects of the popular eye surgery LASIK was not an isolated incident, with others saying the procedure left them with agonizing and life-changing symptoms, patients and doctors told The Post. LASIK providers say the procedure is 95% to 99% safe, but one LASIK survivor said she had suicidal ideations for two years after her “disastrous” surgery in 2000. She also claimed to know of at least 40 people who took their own lives because they couldn’t stand constant pain and vision problems, which developed after the procedure. “The LASIK lobby...

A young Pennsylvania police officer took his own life after he suffered from side effects caused by elective eye surgery, according to his family. Ryan Kingerski, 26, took time off from his job at the Penn Hills Police Department in August to undergo the popular eye surgery, LASIK, in hopes it would improve his vision, his grieving parents, Tim and Stefanie Kingerski, told CBS News Tuesday. However, he began suffering from painful side effects, including headaches, double vision, seeing dark spots and floaters — tiny spots that appear as streaks or cobweb-like shapes across a person’s field of vision, they...

Jay Leno Gets Swollen Eye After Falling Down 60-Foot Hill Comedian Jay Leno says his eye is swollen after he fell down a 60 foot hill. Face swollen an bruised purple. VIDEO AT LINK...............

A study from Tufts University found that daily consumption of pistachios can enhance eye health by increasing macular pigment optical density (MPOD), which helps protect against blue light and age-related eye damage. This benefit is attributed to pistachios’ unique content of lutein, a plant pigment essential for eye health and potentially useful in preventing age-related macular degeneration (AMD). Daily pistachios boost eye health by raising lutein, protecting against age-related damage, and supporting brain function. A recent study by researchers at Tufts University’s Friedman School of Nutrition Science and Policy suggests that eating pistachios daily may greatly benefit eye health. This...

Immediately after Monday’s solar eclipse, the number of people searching Google for eye-related injuries jumped while one doctor in New York City says she treated a surge of patients with eye pain. "I had several patients come in panicking saying ‘I don't want to go blind,’" Dr. Janette Nesheiwat, a New York City-based double board-certified doctor tells Fox News Digital. "I couldn't believe it, people actually looked at the eclipse without protection." Doctors and eye specialists had been warning the public for days not to look directly at the sun, but apparently, some did not heed the advice.

A Brooklyn woman who squinted at the 2017 solar eclipse for 10 seconds without proper eye protection is now warning others of the “irreversible eye damage” she suffered — including a blind spot in the middle of her left iris. Bridget Kyeremateng, 29, told The Post on Monday — hours before a solar eclipse was expected to be partially visible in the Big Apple — that she looked up at the spectacle without any eye protection after being unable to secure a pair of protective glasses, thinking “a couple of seconds wouldn’t do anything. “I couldn’t focus on the sun...

Scientists have identified a new mechanism that regulates a protein key for cell survival. It appears to protect against the excessive oxidative stress that precedes the development of neurodegenerative diseases of the brain and eye. "This discovery goes beyond the commonly studied transcriptional modulation, suggesting its impact on protection against oxidative stress-related diseases and extension of lifespan," notes Dr. Bazan. "We found that Elovanoid-34 modulates the activity of the protein, TXNRD1, which is central to the initiation cascade of oxidative stress." Elovanoid-34 is part of a class of molecules in the brain that synchronize cell-to-cell communication and neuroinflammation-immune activity in...

In a recent randomized, controlled human study, consuming grapes for 16 weeks improved key markers of eye health in older adults. The study looked at the impact of regular consumption of grapes on macular pigment accumulation and other biomarkers of eye health. This is the first human study on this subject, and the results reinforce earlier, preliminary studies where consuming grapes was found to protect retinal structure and function. Science has shown that an aging population has a higher risk of eye disease and vision problems. Key risk factors for eye disease include oxidative stress and high levels of ocular...

A study conducted has demonstrated for the first time that the diagnosis of multiple sclerosis (MS) can be significantly improved by additionally measuring the thickness of retinal layers in the eye. Use of the procedure, which is already available, helps to detect the condition at an earlier stage and predict its progression more accurately. This can lead to a decisive increase in the chance of improved patient outcomes. As part of their investigation, the research team collaborated to examine 267 MS patients over a period of five years. Their research builds on study results, which showed that MS relapse-related damage...

Nearly 10 million Americans are at risk for blindness from diabetic retinopathy, a study finds. In 2021, an estimated 9.6 million people in the United States—26% of those with diabetes—had the eye illness and nearly 2 million had the most severe form, "vision-threatening diabetic retinopathy" (VTDR), researchers say. That's 5% of those with diabetes. Diabetic retinopathy affects small blood vessels in the eye, explained Dr. Talia Kaden. "The small vessels in the eye can become damaged and abnormal, you can have a loss of blood supply to parts of the eye that can result in swelling in the back of...

Millions of people around the world wear contact lenses, including reusable ones. But these plastic lenses don't last forever, and lenses need to be replaced every few days, weeks or months. Though scientists are still grappling to understand the health and environmental impacts of microplastics, it is important to understand where they can appear and what systems they could impact. When measuring aquatic microplastic pollution, researchers generally filter plastic fragments from large amounts of sampled water. The researchers gathered six kinds of contact lenses from various brands and of different lifespans. To mimic normal wear and care, the lenses were...

Repeat treatment with corticosteroid injections improved vision in people with persistent or recurrent uveitis-related macular edema better than two other therapies, according to results from a clinical trial. Compared with methotrexate or ranibizumab intravitreal (in-the-eye) injections, the corticosteroid treatment achieved greater reductions in retinal swelling and was the only therapy in the study that improved vision. Uveitis is a collection of inflammatory conditions that affect the internal tissues of the eye. Inflammation in the eye can lead to fluid buildup in the central part of the eye's light-sensing retina, known as the macula, and decrease vision. This fluid buildup, called...

MADISON, Wis. – Eight months after someone threw two Molotov cocktails into Wisconsin Family Action’s office in Madison, the group’s president is feeling optimistic a cash incentive from the feds will lead to some answers. The FBI is one of three agencies investigating the attack, and on Thursday they announced they would be offering up to $25,000 for information leading to the conviction of whoever is responsible. RELATED: FBI offering $25K reward for information on arson at pro-life group’s Madison office WFA president Juliane Appling said after months of repairs, she and her staff are back at the office and...

A radical leftist biochemist has been charged in connection with the May 2022 firebombing of anti-abortion group Wisconsin Family Action's office in Madison. Hridindu Sankar Roychowdhury, 29, was arrested at Boston Logan Airport on Tuesday as he prepared to board a one-way flight to Guatemala City. During the incident in question, two Molotov cocktails were thrown into the office, and graffiti was spray-painted on the side of the building stating, "If abortions aren't safe then you aren't either." Far-left pro-abortion group Jane's Revenge took responsibility for the attack, claiming that it was "only a warning," and threatening to destroy the...

(CNN) - Recalled eye drops have been linked to dozens of dangerous infections and at least one death. The Centers for Disease Control and Prevention identified 68 patients in 16 states with infections from Global Pharma Healthcare’s Artificial Tears Lubricant Eye Drops. The artificial tears, distributed by Ezricare and Delsam Pharma, were first recalled in February. According to the CDC, patients were infected by a rare strain of drug-resistant bacteria never before reported in the U.S. Eight patients reported losing vision, and four had to have eyeballs surgically removed. One person died. The CDC says anyone who has used Ezricare...

The Food and Drug Administration warned Wednesday of another imported eye product that could be contaminated with bacteria, in the wake of an outbreak earlier this year of highly drug-resistant bacteria that hospitalized and blinded some patients. Americans should stop using Delsam Pharma's Artificial Eye Ointment, the FDA says, an over-the-counter product manufactured by Global Pharma Healthcare Private Limited. The company has agreed to recall the product. It's the same manufacturer behind the EzriCare and Delsam Pharma artificial tears products that were already recalled earlier this year. The FDA had faulted the company for multiple violations and banned imports into...

The CDC has urged several doctors and patients to stop using EzriCare Artificial Tears as it has been linked to 50 bacteria-resistant infections and one death in 11 states, according to a report. Most of the people infected said they used artificial tears, with EzriCare being the most reported brand. EzriCare drops are preservative-free and don’t have any ingredients that prevent bacterial infections from occurring. “CDC recommends that clinicians and patients immediately discontinue the use of EzriCare Artificial Tears until the epidemiological investigation and laboratory analyses are complete,” said the report.

Public health authorities are investigating an outbreak of bacterial infections across the United States caused by over-the-counter eyedrops contaminated with a rare “extensively drug-resistant” bacterial superbug. At least 68 patients in 16 states are suffering from severe side effects after using Artificial Tear eyedrops that were infected with a rare strain of Pseudomonas aeruginosa, the Center for Disease Control and Prevention announced on Tuesday. Last month, Artificial Tears Lubricant Eye Drops, a product used to lubricate dry eyes, was recalled by its manufacturer Global Pharma Healthcare. The drops were distributed by EzriCare and Delsam Pharma and sold at drug stores...

Eyedrops from EzriCare and Delsam Phama were recalled .... As of March 14, a reported 68 patients in 16 states have been infected with this 'rare strain' of Pseudomonas aeruginosa, according to an update by the Centers for Disease Control and Prevention (CDC). Global Pharma Healthcare recalled its Artificial Tears Lubricant Eye Drops that were distributed by EzriCare and Delsam Pharma last month. The drops had been sold at drug stores across the country, including Walmart, Target, and CVS, and on Amazon, though the products have since been pulled.