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It may or may not be the most significant retraction of a scientific paper ever, but it certainly is in the ballpark. The paper helped create and sustain the theory that amyloid protein buildups caused the symptoms of Alzheimer's Disease and was one of a number of apparently fraudulent papers written by Sylvain Lesné, a professor at the University of Minnesota, Twin Cities. All the paper's authors agreed to retract, save Lesné, who has been under investigation for manipulating data. "Authors of a landmark Alzheimer’s disease research paper published in Nature in 2006 have agreed to retract the study in...

Critical elements of one of the most cited pieces of Alzheimer’s disease research in the last two decades may have been purposely manipulated, according to a report in Science. **SNIP** The highly influential paper, which was published in Nature in 2006, has helped guide billions of dollars in US federal government research into Alzheimer’s, according to Science. The study, which looked at cognitive decline in mice, proposed that a specific amyloid protein may be responsible for cognitive decline. The hypothesis has since dominated the field, and researchers have worked for years to understand the mechanism by which such proteins may...

Amyloid protein (orange) forms clumps among neurons (blue). Amyloid in the brain is one of the proteins associated with Alzheimer’s disease, but amyloid clumps in other parts of the body can cause other illnesses. _____________________________________________________________________________ New photo-oxygenation catalyst targets amyloid structure, recruits brain immune system cells. A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer’s disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused by similar amyloids. Researchers injected the...