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Alzheimer's Association Supplemental thiamine [vitamin B-1] as a practical, potential way to prevent Alzheimer's disease from commencingFirst published: 28 July 2021 Author: Jeffrey Fessel “… In brief: it is easier to prevent Alzheimer's than to try to reverse it after it has developed. The data supporting the prophylactic use of thiamine are robust. In order to validate its use, a clinical trial is advocated that would enroll persons aged 65 or older who have evidence of depositions of amyloid or tau in their brains, and randomly assign them to take, for as long as 5 years, either thiamine 100 mgs...

Elite tennis players have an uncanny ability to clear their heads after making errors. They constantly move on and start fresh for the next point. They can’t afford to dwell on mistakes. Peter Strick is not a professional tennis player. He’s a distinguished professor and chair of the department of neurobiology at the University of Pittsburgh Brain Institute. He’s the sort of person to dwell on mistakes, however small. . . . . . .For a long time, it has been understood that the adrenal glands were turned on and off by a couple discrete pathways coming from the brain....

To help protect older adults from financial exploitation, researchers are working to understand who is most at risk. New findings suggest that willingness to give away money could be linked to the earliest stages of Alzheimer's disease. Sixty-seven older adults who did not have dementia or cognitive impairment completed a laboratory task where they decided whether to give money to an anonymous person or keep it for themselves. They also completed a series of cognitive tests, such as word and story recall. Those who gave away more money performed worse on the cognitive assessments known to be sensitive to Alzheimer's...

Researchers have found that oral administration of rapamycin to an Alzheimer's disease mouse model causes an increase in beta (β)-amyloid protein plaques. β-amyloid buildup is a hallmark of Alzheimer's disease. Rapamycin is approved to treat transplant and cancer patients. Publicly available data suggest that the drug might also improve learning and memory in aged mice. However, the researchers observed that after rapamycin treatment, a protein called Trem2 (triggering receptor expressed on myeloid cells 2) is dramatically diminished. Trem2 is present in microglia, which are immune cells in the brain and spinal cord. "Trem2 is a receptor located on the surface...

Fragmented tau that accumulates in neurons in those with Alzheimer’s disease may be a new target for drugs to treat the neurodegenerative disease. The form of tau, which is broken into fragments that accumulates in the brains of people with Alzheimer’s, is likely to play a role in the degenerative progression associated with the condition, the researchers say. It is distinct from other tau accumulations that have been the focus of earlier drug development. Because this type of truncated tau protein is not present in the brains of patients with most other forms of dementia, measuring the fragments in cerebrospinal...

Summary: Our brains lose the ability to link related memories as we age. Scientists genetically restored this brain function in middle-aged mice and identified an FDA-approved drug that achieves the same thing. The study suggests a new approach for combating middle-aged memory loss and a possible early intervention for dementia. Share:FULL STORY Our brains rarely record single memories -- instead, they store memories into groups so that the recollection of one significant memory triggers the recall of others connected by time. As we age, however, our brains gradually lose this ability to link related memories. Now UCLA researchers have discovered...

Think twice before popping these pills that shrink your brain, kill your memory and put you in the path of a deadly disease with no cure. One person made an astonishing recovery from severe dementia after quitting multiple meds – including over-the-counter products. Be very careful. Story at-a-glance Anticholinergic drugs block acetylcholine, a neurotransmitter that performs important functions in your brain and peripheral and central nervous systems In your brain, acetylcholine plays a key role in attention, concentration, memory formation and consolidation, which is why anticholinergic drugs can cause symptoms identical to dementia Research assessing effects of anticholinergics found statistically...

In a new study conducted in rats, scientists report evidence that vitamin K could help protect against aging-related cognitive declines associated with Alzheimer's disease and other forms of dementia. "Vitamin K2 demonstrated very promising impact in hindering aging-related behavioral, functional, biochemical and histopathological changes in the senile aging brain," said Mohamed El-Sherbiny, Ph.D. Vitamin K is a group of compounds that includes vitamin K1, found in leafy greens and some other vegetables, and vitamin K2, found in meats, cheeses and eggs. Previous studies have linked vitamin K with processes involved in brain functioning, and some studies have associated vitamin K...

President Joe Biden has consistently struggled with anger outbursts when peppered with unwanted questions — especially questions about the Biden family corruption. All throughout the presidential campaign and into his presidency, Biden has consistently used anger in an attempt to dispel questions he does not want to answer. According the Republican National Committee’s research team on Monday, Biden has leveraged his defensive anger at least five times when questioned about his family’s business dealings.

A new study shows that a potential treatment for Alzheimer's disease may also improve cognitive function in people with Down syndrome. The drug sargramostim (GM-CSF, which stands for granulocyte-macrophage colony-stimulating factor) is the first to show memory improvement in Alzheimer's patients in a phase II clinical trial. GM-CSF is a normal human protein that is safe and well-tolerated with over 30 years of FDA-approved use for other disorders. A multidisciplinary team studied the safety and tolerability of GM-CSF treatment and its effects on behavior and brain pathology in a mouse model of Down syndrome and in mice undergoing typical aging....

Alzheimer's disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau. A study has shown that targeting astrocytes—an inflammatory cell in the brain—reduces tau-related brain damage and inflammation in mice. The findings highlight the pivotal role of astrocytes in driving brain damage in tauopathies, and open up new avenues toward better therapies for the group of devastating and difficult to treat conditions. "Brain inflammation is emerging as a contributor to the development of Alzheimer's disease, and that inflammation is driven by non-neuronal cells in the...

In a letter, signed by 37 of his Republican colleagues in Congress, Texas Rep. Dr. Ronny Jackson warns that President Biden's "mental decline and forgetfulness have become more apparent over the past two years," and urges the 79-year-old to take a cognitive aptitude test (just as former President Trump did).“My colleagues and I are again asking President Biden to immediately undergo a formal cognitive screening exam, such as the Montreal Cognitive Assessment,” Jackson said.“As a former physician to three Presidents of the United States, I know what it takes mentally and physically to execute the duties of Commander-in-Chief and Head...

The 48-year political veteran made the claim while visiting a Mack Truck facility in Pennsylvania on Wednesday. “I used to drive an 18-wheeler, man,” the 78-year-old commander-in-chief told staff, video of the exchange shows — with him clarifying that he “got to” drive one. But challenged by Fox News to produce evidence, a White House spokesperson could only point to a December 1973 article from the Wilmington Evening Journal that showed Biden rode in an 18-wheeler, not that he drove one.

Thirty-eight Republican lawmakers on Wednesday demanded President Joe Biden take a cognitive test upon fears that he may have Alzheimer’s disease. Noting Biden’s “changes in mood and personality” and “forgetfulness,” the 38 Republican lawmakers sent a demand letter for the president to undergo a transparent cognitive test. Biden took a physical examination in November, but he “either did not have a cognitive test or those results were withheld from the public,” the letter stated:

Alzheimer’s disease (AD) is the most common form of dementia. It is expected to affect 16 million Americans by 2050. The hallmarks of AD are amyloid plaques and tau neurofibrillary tangles in the brain. Efforts to develop new drugs that directly target amyloid or tau proteins haven’t yielded significant clinical benefits for patients. Another approach to developing AD treatments would be to seek existing drugs that could potentially be repurposed. A team of researchers led by Dr. Feixiong Cheng at the Cleveland Clinic developed a computational method for identifying FDA-approved drugs that might be effective against AD. NIH’s National Institute...

Fox News White House correspondent Peter Doocy said Monday on FNC’s “Hannity” that President Joe Biden called him to “clear the air” after calling him a “stupid son of a bitch,” which was caught on a hot microphone. After the press conference, Doocy asked Biden, “Do you think inflation is a political liability in the midterms?”

— Proposal would cover aducanumab (Aduhelm) in patients on qualifying clinical trialsMonoclonal antibodies targeting amyloid beta in Alzheimer's disease, including the newly approved drug aducanumab (Aduhelm), would be covered for people with Medicare only if they are enrolled in qualifying clinical trials, according to CMS plans announced Tuesday. The proposed CMS National Coverage Determination would cover FDA-approved monoclonal antibodies targeting amyloid in Alzheimer's disease through coverage with evidence development (CED). To date, the only such approved treatment is aducanumab. "Throughout this National Coverage Determination process, CMS has been and remains committed to providing the American public with a clear, trusted,...

Dementia is thought to occur when proteins accumulate in the brain and form oligomers. Research previously shown that the antibiotic rifampicin removes oligomers from the brain and improves cognitive function. However, the drug has been associated with side effects such as liver damage. Resveratrol, an antioxidant in plants, is used as a supplement. "To combat the negative side effects of rifampicin, we thought of combining it with the hepatoprotective effects of resveratrol," says Professor Tomiyama. This time, the research group administered a fixed dose combination of rifampicin and resveratrol intranasally five days a week for a total of four weeks...

A bit of good news as we kick off 2022. It turns out coffee is your friend. And it is very good for you, as first outlined in this report from 2017:A meta-analysis of 127 studies conducted in 2017 revealed that daily drinking two to four 8-ounce cups of coffee decreases risk of cancer by 20 percent, Type 2 diabetes by 30 percent, and Parkinson's by 30 percent. Furthermore, a huge study in the UK found that those who drink a LOT of coffee live longer than those who don't.Wow, that’s high praise; you would think that would be enough...

Researchers say that they may have discovered the molecular-level cause of Alzheimer’s disease.Scientists at the University of California–Riverside said in recent findings that the key to understanding Alzheimer’s may have to do with “tau” proteins that likely cause neurofibrillary tangles—which are found in the brains of Alzheimer’s patients. Previously, researchers suggested that amyloid plaques, which are a buildup of amyloid peptides, may be the cause.Both amyloid plaques and neurofibrillary tangles are critical indicators that doctors look for when trying to diagnose Alzheimer’s.“Roughly 20 percent of people have the plaques, but no signs of dementia,” said UCR chemistry professor Ryan Julian...