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Run time 19 m 26 s Minnesota Senator Fought the Release of This Bodycam.

Alzheimer’s disease, long seen as a disorder of the aging brain, may actually begin in an unexpected place: the mouth.Researchers reported evidence that a bacterium commonly associated with chronic gum disease could play a direct role in the development of Alzheimer’s. The study, published in Science Advances, details how Porphyromonas gingivalis, the pathogen behind periodontitis, was detected in the brains of Alzheimer’s patients. The findings come from an international team of scientists that included Jan Potempa, a microbiologist at the University of Louisville. Potempa said the research offers some of the strongest evidence yet linking gum infection to Alzheimer’s pathology,...

Can these toxic chemicals speed up or even cause the disease?As we age, we tend to become more focused on our health. Besides heart disease, diabetes, and cancer, we also have to worry about cognitive decline. Nearly seven million Americans live with Alzheimer’s disease, according to the Alzheimer’s Association. One in 14 people develops the disease by age 65, and one in three is diagnosed by 85. Among the most common neurodegenerative disorders, Alzheimer’s is also a top cause of death for individuals 65 and older. Now, new studies suggest that just three weeks of exposure to microplastics can lead...

Scientists at UCSF have uncovered a surprising culprit behind brain aging: a protein called FTL1. In mice, too much FTL1 caused memory loss, weaker brain connections, and sluggish cells. But when researchers blocked it, the animals regained youthful brain function and sharp memory. The discovery suggests that one protein could be the master switch for aging in the brain — and targeting it may one day allow us to actually reverse cognitive decline, not just slow it down.

St.Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. The finding could inspire new drugs that harness midkine’s protective power.

Gates is calling on global innovators to harness A.I. against the growing Alzheimer’s crisis.More than 7 million Americans are currently living with Alzheimer’s disease—a figure expected to rise as life expectancies increase. To help accelerate progress, Bill Gates and a coalition of partners are backing a new A.I. competition designed to spur breakthroughs in Alzheimer’s and related dementia research. Unveiled today (Aug. 19) by the Alzheimer’s Disease Data Initiative (AD Data Initiative), the competition will award a $1 million prize to a team that successfully utilizes agentic A.I. to develop innovative solutions. The resulting tools will be made publicly available...

What is the earliest spark that ignites the memory-robbing march of Alzheimer's disease? Researchers may have found an answer: lithium deficiency in the brain. The work shows that lithium occurs naturally in the brain, shields it from neurodegeneration, and maintains the normal function of all major brain cell types. The findings are based on experiments in mice and on analyses of human brain tissue and blood samples from individuals in various stages of cognitive health. The scientists found lithium loss in the human brain is one of the earliest changes leading to Alzheimer's, while in mice, similar lithium depletion accelerated...

Eight essential nutrients make up the suite of B vitamins also known as the B complex. Research has revealed that these B vitamins influence a vast spectrum of human health and disease. "It's hard to study the B vitamins in isolation," says gastroenterologist Joel Mason. "Four of these B-vitamins cooperate as co-factors in many critical activities in cells in what we call 'one carbon metabolism.'" One of the most active areas for B vitamin research is cognitive health. By the age of 75–80, 40% of people have a diminished ability to absorb food-bound B12, says Mason. This deficiency leads to...

[H/T grey_whiskers]Via Valerie Anne Smith“Ivermectin’s Miraculous Results For Neurological Conditions Of Parkinson’s & Alzheimer’s.”Buried Research, Deleted From Google, Has Been Found, Proving Ivermectin Reverses Alzheimer’s.Neurological Disease Improves In Only A Few Days On Ivermectin Therapy…Dementia affects more than 55 million people globally, with Alzheimer’s disease (AD) being the most prevalent subtype. These neurodegenerative disorders, including debilitating Parkinson’s Disease, progressively impairs memory, cognition, daily functioning, muscle & body control.As interest grows in repositioning known compounds for neurodegenerative applications, ivermectin—a macrocyclic lactone with FDA-approved antiparasitic use—has surfaced as a candidate for neurological disease therapy.Deleted Research Study That Google Scrubbed… I Found It...

In A Nutshell * Two FDA-approved cancer drugs — letrozole and irinotecan — significantly improved memory and reduced brain damage in mice with Alzheimer’s. * The combination therapy targets multiple brain cell types by reversing gene disruptions in neurons and glia. *Real-world medical records of 1.4 million patients show lower Alzheimer’s rates in people treated with these drugs for cancer. * The findings offer a new multi-target strategy that may outperform existing single-drug treatments, but human trials are still needed. SAN FRANCISCO — Two cancer medications already on pharmacy shelves might hold the key to treating Alzheimer’s disease, and early...

Insulin resistance detected by routine triglyceride-glucose (TyG) index can flag people with early Alzheimer's who are four times more likely to present rapid cognitive decline, according to research. Neurologists reviewed records of 315 non-diabetic patients with cognitive deficits, including 200 with biologically confirmed Alzheimer's disease. All subjects underwent an assessment of insulin resistance using the TyG index and a clinical follow-up of three years. When patients were divided according to the TyG index, those in the highest third of the Mild Cognitive Impairment AD subgroup deteriorated far more quickly than their lower-TyG peers, losing >2.5 points on the Mini Mental...

As you’ve likely already heard, Biden has cancer. Again. We don’t yet know whether this one will stick, but it looks more legitimate than President Autopen’s previous cancer claims. Yesterday, the New York Times ran the story below the headline, “Joe Biden Is Diagnosed With an Aggressive Form of Prostate Cancer.” The announcement by his office, which created the story, conveniently streamed into media offices two days before the controversial exposé book Original Sin was due for release. CLIP: Biden rambles about how he got oil cancer in 2022 (0:27).Hearing the news, some uncharitable people are casting a skeptical eye...

Plasma assessment is not intended as a screening or stand-alone diagnostic test, agency saysThe FDA cleared the first blood-based in vitro diagnostic test for Alzheimer's disease, the agency announcedopens in a new tab or window Friday. The blood test, known as the Lumipulse G pTau 217/β-Amyloid 1-42 Plasma Ratio, can be used to detect amyloid plaques associated with Alzheimer's in people ages 55 and older who have signs and symptoms of the disease, the agency said. "Alzheimer's disease impacts too many people, more than breast cancer and prostate cancer combined," FDA Commissioner Martin Makary, MD, MPH, said in a statement....

The implications of this research could redefine the boundary between life and death. ================================================================= About five years ago, Yale School of Medicine neuroscientist Zvonimir Vrselja, Ph.D., and his colleagues shocked the medical community with a groundbreaking experiment. They removed a slaughterhouse pig’s brain from its head and deprived it of oxygen at room temperature for four hours. Then, they hooked it up to their resuscitation machine and revived it—to an extent. A living brain’s vasculature, or network of blood vessels, carries oxygenated, nutrient-rich blood to the brain through arteries and capillaries. So, the researchers used their machine, called BrainEx, to...

A team of scientists has tested four anti-amyloid Alzheimer's therapeutics to find out how the drugs bind to toxic amyloid beta protein to tackle the disease. Using new, highly sensitive methods, the researchers detected and visualized how amyloid beta protein—a plaque that builds up in the brains of people with Alzheimer's disease—binds to lecanemab, donanemab, gantenerumab and aducanumab. The findings show that lecanemab performs the best at binding a small, soluble form of amyloid beta, suggesting that it is most effective, when used as early as possible in the disease progression. Amyloid beta is one of the toxic proteins that...

In a nutshell One dose of a psychedelic compound (25CN-NBOH) significantly improved cognitive flexibility in mice, even 2 to 3 weeks after the drug was administered. Treated mice adapted better to new learning rules in a reversal task, showing stronger performance across multiple behavioral measures compared to controls. These long-lasting effects suggest psychedelics may promote meaningful, enduring changes in brain plasticity, offering potential new approaches for treating conditions like depression, PTSD, and Alzheimer’s disease. ANN ARBOR, Mich. — A single dose of a psychedelic compound could be key to helping your brain become more adaptable for weeks. University of Michigan...

A pause to NIH funding has researchers scrambling for contingency plans at the University of Washington’s Alzheimer’s Disease Research Center. The center’s brain bank is preserving more than 4,000 brains for research. SEATTLE — Andrea Gilbert thought she knew what would happen to her brain. The 79-year-old retired attorney, who has Alzheimer’s disease and receives care at Harborview Medical Center in Seattle, agreed to donate it for research in 2023. She hoped to help scientists unlock the keys to a disease that had left her writing notes to remind herself if she’d already brushed her teeth. The fate of that...

Duck Dynasty star Jase Robertson revealed that his father, Phil Robertson was “not good,” months after it was revealed he had been diagnosed with the “early stages” of Alzheimer’s disease. During a recent episode of Unashamed with the Robertson Family, Jase, his brother Alan Robertson, and their cousin Zach Dasher provided an update on Phil’s health, and Phil’s wife, Kay Robertson’s health. “For my mom, it’s been a lot better this past week, because she was really not doing good,” Jase explained. “She got an infection from a fall — from a cut that had happened earlier.” Jase continued to...

Scientists have long recognized the brain's need for energy, but new research has now illuminated how the brain's energy utilization significantly influences our sleep patterns. The team discovered certain channels in the brain, called ATP-sensitive potassium (KATP) channels, act as energy sensors and play a pivotal role in maintaining stable sleep-wake cycles and facilitating smooth transitions between cycles. "Our study shows that even small changes in energy usage can profoundly impact behavior," said Macauley. These changes impact when we sleep, how we sleep and the overall quality of our sleep. The study identified a previously unknown function of KATP channels...

The herb rosemary has long been linked with memory. So it is fitting that researchers would study a compound found in rosemary and sage—carnosic acid—for its impact on Alzheimer's disease. Carnosic acid is an antioxidant and anti-inflammatory compound that works by activating enzymes that make up the body's natural defense system. Scientists have now synthesized a stable form, diAcCA. This compound is fully converted to carnosic acid in the gut before being absorbed into the bloodstream. The research showed that when diAcCA was used to treat mouse models of Alzheimer's disease, it achieved therapeutic doses of carnosic acid in the...