Free Republic

The last living grandson of the 10th U.S. President John Tyler has died at 96 years old — the end of a link to a bygone era of American history.

A widely used antidepressant drug could help the immune system fight cancer, according to a new research study. Selective serotonin reuptake inhibitors, or SSRIs, significantly enhanced the ability of T cells to fight cancer and suppressed tumor growth across a range of cancer types in both mouse and human tumor models found. Yang and her team first began investigating serotonin's role in fighting cancer after noticing that immune cells isolated from tumors had higher levels of serotonin-regulating molecules. The researchers tested SSRIs in mouse and human tumor models representing melanoma, breast, prostate, colon and bladder cancer. They found that SSRI...

A study has uncovered a surprising link between diet, intestinal microbes and the efficacy of cancer therapy. The study could help explain why drugs known as PI3 kinase (PI3K) inhibitors—which disrupt an abnormally activated biochemical signaling pathway that spurs cancer cell proliferation—haven't led to consistent, durable cancer control in patients with solid tumors. The Rabinowitz lab and others have shown that ketogenic diets dramatically enhance responses to cancer drugs in preclinical mouse models of cancer. Such diets are rich in fat and very low in carbohydrates like starch and sugar, and their enhancement of therapeutic responses was thought to be...

Investigators report that one in four hypersensitivity pneumonitis cases in their interstitial lung disease registry could be traced back to mold inside patients' homes, identifying chronic exposure to residential mold as a potential source of severe immune-mediated lung condition. Household exposure has been associated with a range of illnesses, including asthma, chronic rhinosinusitis, and allergic bronchopulmonary mycosis. Physicians are often unable to connect residential environments with patient symptoms, in part due to limited diagnostic tools. Without clear exposure histories or validated testing methods, the role of mold in respiratory disease remains easy to miss. In the study, researchers retrospectively examined...

As former first lady Michelle Obama tells it, it’s not easy being married to a famous man, describing people "spilling water" on her while trying to reach her husband. Both Obama and her guest, OB-GYN Dr. Sharon Malone, who joined the podcast that Obama co-hosts with her brother, "IMO with Michelle Obama & Craig Robinson," discussed the challenges of being married to famous men on Wednesday. Malone’s husband is former Attorney General Eric Holder, who was the 82nd attorney general of the United States from 2009 to 2015 under former President Barack Obama. Michelle Obama recounted the first time she...

Ed Martin has a plan to end the criminal weaponization of the federal government and to hold accountable those who wielded it, he explained on The Alex Marlow Show. Martin is barely a week into his new position as Associate Deputy Attorney General, but he already has an aggressive yet straightforward three-step plan to deliver on President Donald Trump’s charge to root out government corruption and hold the corrupt accountable. The first step is perhaps the simplest. “Tell the truth,” Martin told Breitbart Editor-in-Chief Alex Marlow, promising to call out those who have weaponized the government against the American people....

Marilyn Howard Ellman, the youngest daughter of The Three Stooges star Curly Howard, died May 6 in Simi Valley of heart failure, her son Bradley Server told The Hollywood Reporter. She was 86. With her parents divorced and her father often on the road at the height of his career in the early 1940s, Ellman only got to visit him maybe two weekends a month, her son noted. Later, she would spend time with him in the hospital after he had suffered a series of strokes, one of which forced him to leave The Three Stooges in 1946. “My mom...

ORLANDO, Fla. - A Maryland woman has been arrested and charged with child abuse after allegedly striking a boy aboard a plane at Orlando Sanford Airport, authorities said. Kristy Crampton, 46, of Hagerstown, Maryland, allegedly hit the child after he called her "fat" and "Miss Piggy" on a flight home from Disney World on Memorial Day, according to a Sanford Airport Police report. Witnesses told police that Crampton struck the boy and slammed his head against a window following a verbal argument. One witness described the incident as abuse, stating the "woman was not correcting the child, she was abusing...

A huge portion of a glacier in the Swiss Alps has broken off from the mountainside, sending rock, mud and ice crashing onto the village of Blatten. Authorities have been warning of a potential collapse of the Birch glacier for weeks now as cracks appeared in the ice. Earlier this month, villagers and livestock were evacuated from Blatten, which sits in the valley below the glacier and is home to around 300 people. Webcam and drone images from 28 May show enormous plumes of dust billowing into the Alpine valley as the glacier collapsed, with a huge wave of mud...

A study of almost 400,000 people is the first to indicate, in humans, that the signaling of substances called short-chain fatty acids or SCFAs, released when gut bacteria break down dietary fiber, significantly protects against cardiovascular disease and hypertension by up to 20%. A previous clinical trial has shown these SCFAs—when provided as a supplement—lead to lowered blood pressure. Another trial is underway. The current study used data from the UK Biobank database and found rare genetic variants that profoundly impact the function of receptors that bind to SCFAs essentially prevent people from utilizing the cardiovascular protection offered by their...

"...look how mad Whoopy is, she mad ..."

The State Board of Education suspended Jesse Ruiz's license for two years after finding he wrote inappropriate messages in students' yearbooks. (the message was "hail satan")

Abstract Many psychologists, particularly feminist psychologists, have drawn a distinction between the term sex and the term gender. The purposes of this paper were to review the history of this distinction and to illustrate the varied and inconsistent ways in which these terms are used. Historically, this distinction began with John Money and his colleagues in the 1950s (Money et al. 1955a, b, 1957); they used the term sex to refer to individuals’ physical characteristics and the term gender to refer to individuals’ psychological characteristics and behavior. Two decades later, Rhoda Unger (1979) argued that the widespread use of the...

MAGA showed up BIG for FREE SPEECH at the Lakeland Farmers Market after they tried to ban me last week! Featuring the great ‪@AdamFrancisco‬!

A federal court on Wednesday blocked President Donald Trump from imposing sweeping tariffs on imports under an emergency-powers law, swiftly throwing into doubt Trump’s signature set of economic policies that have rattled global financial markets, frustrated trade partners and raised broader fears about inflation intensifying and the economy slumping. The ruling from a three-judge panel at the New York-based U.S. Court of International Trade came after several lawsuits arguing Trump’s “Liberation Day” tariffs exceeded his authority and left the country’s trade policy dependent on his whims. But for now, Trump might not have the threat of import taxes to exact...

The US senator Amy Klobuchar says she hopes her party does not reflexively rule out running a woman for the White House after Kamala Harris – her fellow Democrat – lost to her Republican rival Donald Trump in November’s presidential election, arguing it is not the “lesson to learn”. Responding to a question Sunday on NBC’s Meet the Press about whether Harris’s defeat might dissuade Democrats from nominating a female presidential candidate, Klobuchar said: “You have seen women run other countries quite well” before singling out the former German chancellor Angela Merkel as an example. Klobuchar added, “You’ve also seen...

[Catholic Caucus] Father Chris Alar speaks out against suppression of Latin Mass in CharlotteOn this episode of Faith and Reason, Father Chris Alar, MIC, joins John-Henry Westen to discuss the bishop of Charlotte’s crackdown on the Traditional Latin Mass (TLM), Pope Leo XIV’s first bishop appointments, Archbishop Salvatore Cordileone’s project aimed at renewing reverence in the liturgy, and more. The panel opened the episode by discussing Bishop Michael Martin’s suppression of the Traditional Latin Mass (TLM) in the Diocese of Charlotte. Martin ordered last week that the Latin Masses at all parish churches – 4 in total – be merged...

~ The FReeper Canteen Presents ~ ~ Remembering Our Troops!! ~ Feeding Our Troops At 19 Below Zero! Breakfast items are set in trays inside a mobile kitchen trailer in Helena, Montana, Feb. 2, 2022. The Soldiers had to endure temperatures as low as minus 19 while providing food for the fighting force as part of the Phillip. A. Connelly Active Field Competition. The Field Competition puts all aspects of a culinary team’s field capabilities under a microscope to include food quality, creativity and proficiency. (U.S. Army Photo by Spc. Jordan S. Worthy) Canteen Mission StatementShowing support and boosting...

SNIP During the interview, Shem Tov also explained why members of Hamas were allegedly rooting for Kamala Harris to win the presidency: SHEM TOV: Yes, it’s him. He got me out. He got the hostages out. Before we we felt like nothing is happening; I remember there, for me there, ever since he came into into the road, they were very scared of him. They wanted - GOLODRYGA: Who? SHEM TOV: Terrorists. GOLODRYGA: Were afraid of Trump? SHEM TOV: Yeah. They wanted Kamala to be chosen. GOLODRYGA: You talked politics with them? SHEM TOV: Yeah, yeah, yeah. They wanted Kamala...

As the battle with drones continues, motorcycles have become a rising star in Ukraine's war. The Ukrainian military's 425th separate assault regiment, nicknamed "Skala," announced on Tuesday that it had officially formed the country's first motorcycle attack company. "As a result, we now have a modern 'cavalry' whose main task is to rapidly break through to enemy positions, conduct assault operations, and quickly shift the direction of attack," it said on its Telegram channel. The use of motorcycles to carry troops into battle is well-documented in Ukraine. Since early last year, Russian troops have been increasingly seen riding on light...