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A type of immune therapy called chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of multiple types of blood cancers but has shown limited efficacy against glioblastoma and other solid tumors. New research suggests that drugs that correct abnormalities in a solid tumor's blood vessels can improve the delivery and function of CAR-T cell therapy. With CAR-T cell therapy, immune cells are taken from a patient's blood and are modified in the lab. "One of the main reasons that CAR-T therapy hasn't worked well against solid tumors is that intravenously administered cells are only capable of migrating to...

Composite X-ray, radio and optical image of the distant quasar galaxy 3C 297. (NASA/CXC/Univ. of Torino/V. Missaglia et al./ESA/STScI & International Gemini Observatory/NOIRLab/NSF/AURA/NRAO/AUI/NSF) It's the classic social faux pas. You're in a happy clique, surrounded by all your friends – and one by one, you subsume them, absorbing them into yourself, until you're all alone, a grotesque agglomeration alone in what was once a crowded environment. That seems to be what happened to a galaxy 9.2 billion years ago, scientists have determined. A galaxy in the relatively early Universe named 3C 297 is mysteriously all alone – even though its...

Former Cowboys wide receiver Michael Irvin has moved his $100 million lawsuit against Marriott from a federal court in Texas to an Arizona state court and scheduled a news conference Tuesday at which he and his attorney plan to show the surveillance video capturing the Feb. 5 conversation between Irvin and a Phoenix hotel staffer that is at the center of his complaint. Irvin filed paperwork Monday for the lawsuit’s voluntary dismissal from Eastern District federal court. But the lawsuit is still alive, and no settlement has been reached between the sides. The case moved because Irvin and his legal...

The following report by Clare Lopez was published earlier this month by Sharia TipSheet.Hady Amr is a Beirut-born Deputy Assistant Secretary of State in the Biden Administration“Biden Sends Pro-Hamas Envoy ‘Inspired by Intifada’ to Mediate Between Israel and Jihad Terrorists”, Jihad Watch, by Daniel Greenfield, May 14, 2021 “Hady Amr’s transformational policy”, Jewish News Syndicate, by Caroline Glick, March 2, 2023Hady Amr is the U.S. Special Representative for Palestinian AffairsMaher Bitar is a Palestinian American, appointed as Senior Director for Intelligence Programs at Biden’s National Security Council. He was an Executive Board member of Georgetown University’s chapter of Students for...

The U.S. Army’s new brand and ad campaign largely omits reference to woke identity politics and could be just what the service needs to overcome historic recruiting obstacles, experts told the Daily Caller News Foundation. Prior advertising efforts alienated conservative families that once served as the Army’s primary recruiting base, according to experts. They “forgot that the primary market for Army recruiting is young men from traditional families, looking for a challenge,” Elaine Donnelly, president of the Center for Military Readiness, told the DCNF. The Army’s new branding campaign, unveiled Wednesday, shied away from social justice and diversity themes as...

The media is condemning officials in Republican-led states for withdrawing from a controversial data-sharing consortium that purports to help manage voter registration rolls and, not surprisingly, the news reports fail to tell the whole story. The system is known as the Electronic Registration Information Center (ERIC) and it claims to be an efficient and cost-effective mechanism for states to maintain accurate voter rolls. ERIC is a nonprofit that was formed by leftist operatives in 2012 and, until recently, had more than 30 member states. It claims that its sole mission is assisting states to improve the accuracy of America’s voter...

Food is up 10.2% YoY. Electricity up 12.9%, shelter up 8.1%.

Several of the highly-buzzed Republican presidential hopefuls have responded to Tucker Carlson's questions pressing their stance on the ongoing war between Russia and Ukraine. Last week, the Fox News host challenged the already-declared candidates as well as several prominent Republicans who have sparked chatter of potentially entering the 2024 race to answer a questionnaire that asked the following: Is opposing Russia in Ukraine a vital American national strategic interest? What specifically is our objective in Ukraine, and how will we know when we’ve achieved it? What is the limit of funding and materiel you would be willing to send to...

Early in the morning hours of a polar vortex in January 2019, FOX's "Empire" actor Jussie Smollett claimed two White supremacist Trump supporters attacked him near his Chicago apartment in a racially-motivated hate crime that would soon incite outrage from activists and the media. It's the "hate crime" that dominated headlines, but facts proved none of it was true. In December 2021, the now-40-year-old actor and singer was convicted of five felony counts of disorderly conduct. One year ago, he was sentenced in March 2022 to 150 days in county jail. Brothers Abimbola "Bola" and Olabinjo "Ola" Osundairo, Smollett's accomplices...

The Democrat-run city of Newark, New Jersey, recently formalized its sister city partnership with the Hindu nation of Kailasa. Evidently, city officials did not consult a map before doing so. The "United States of Kailasa" does not exist. It is the invention of an accused rapist who has been on the run from Indian authorities since 2019 for child abduction and other crimes. Newark residents have spoken out about Democrat officials' failed foray into foreign policy, questioning whether anyone at City Hall is capable of performing a simple Google search. A sisterhood of deception According to its website, the so-called...

Blaze host Glenn Beck has accused Facebook of shadow-banning him and his entire Blaze staff after he commented about the release of the Tucker Carlson January 6th tapes. Beck had Carlson on his show last week, and after the interview, he claims that Facebook fact-checked him, sending a warning to him and all his pages. Beck says that Facebook threatened to reduce distribution because he shared “false” information. In a statement on his Facebook page, Beck said that his video commenting on Tucker Carlson’s release of the January 6th footage was hit with an absurd, propagandistic fact check. He claims...

On Monday, Joe Biden claimed during a speech that the recent collapse of both Silicon Valley Bank and Signature Bank was due in part to the Trump administration rolling back parts of the Dodd-Frank Act of 2010."During the Obama-Biden administration, we put in place tough requirements on banks, like Silicon Valley Bank and Signature Bank including the Dodd-Frank law to make sure that the crisis we saw in 2008 would not happen again," Biden said. "Unfortunately, the last administration rolled back some of these requirements."According to the Hill, Trump signed a bipartisan bill in 2018 that loosened some of the...

Over 1.2 million registered voters have been removed from Los Angeles County, California voter rolls due to not voting in recent federal elections and failing to respond to notices since 2022, according to Judicial Watch.Judicial Watch agreed to a settlement agreement with L.A. County in 2019 after suing them for violating the National Voter Registration Act (NVRA) by failing to properly maintain the county’s voter rolls.“That’s a massive tool for fraudsters seeking fraudulent ballots to cast. Who knows how many invalid registrations exist across the country?” Former Missouri State Senator, John Loudon, wrote in a post on Truth Social on...

Senator Elizabeth Warren (D-MA) Monday on MSNBC’s “The Rachel Maddow Show” claimed it was former President Donald Trump’s “bank regulation reliefs” that needed to be rolled back to protect against more banks collapsing like Silicon Valley Bank last week.Warren said, “The way to understand this crisis is that it has three players. The first is Congress and President Trump, who says, let’s weaken the regulation, which hit really hard. The second part is the regulators themselves and, in particular, the Fed and Jerome Powell, the chairman of the Federal Reserve Bank, who took that change in the laws and he...

Former President Donald Trump told Breitbart News exclusively that his forthcoming book will show readers that he has had a “very fascinating life” and that many of the powerful people who attack him now used to adore him before he ran for president.The book, titled Letters to Trump, is the former president’s second book release since leaving office in January 2021. The first one, Our Journey Together, was a collection of historic photos from Trump’s time in office. This book collects letters that Trump sent and received from interesting, famous, powerful, and influential people over the years, both during his...

As you know, Silicon Valley Bank has folded along with Signature Bank and a few other banks are showing signs of trouble. Predictably, Joe Biden- on whose watch his happened- immediately blamed Donald Trump. President Joe Biden blamed former President Donald Trump for the collapse of Silicon Valley Bank (SVB) and Signature Bank, attributing their demise to Trump’s rollback of some Obama-era policies. “During the Obama-Biden administration, we put in place tough requirements on banks like Silicon Valley Bank and Signature Bank, including the Dodd-Frank law to make sure that the crisis we saw in 2008 would not happen again,”...

A close family member of a victim who committed suicide under duress caused by the illegal and unconstitutional Jan. 6 probe is speaking out on the cold and callous behavior of Florida Governor Ron DeSantis. Matthew Perna committed suicide in March 2022 after being hit with a multitude of charges for peacefully protesting in and around the U.S. Capitol on Jan. 6. His aunt, Geni Perna stated in a recent interview that DeSantis ignores all of the calls from Jan. 6 whistleblowers who are speaking out against the injustices that are being perpetrated upon pro-MAGA patriots by the federal government....

She can break a tie in the Senate but, apparently, Vice President Harris has no such voting power during Netflix viewing debates at home. “Right now, it’s definitely Netflix and chilling,” Doug Emhoff, the Georgetown University Law Center instructor and Harris’s husband, told Cosmopolitan of the couple’s favorite date night activity in an interview published Monday. “It’s hard to go out, so we’ll sit there and try to find something to watch,” Emhoff said, “and it takes so long to find something to watch, so it’s like, ‘Eh, let’s just go to bed.’ ” Fifty-eight-year-old Emhoff, who opened up to...

More than $100bn has been wiped off US banks’ value as the collapse of Silicon Valley Bank continues to send shockwaves throughout Wall St. Trading was temporarily halted in dozens of regional banks this morning as shares fell by up to 75 percent, despite Joe Biden’s assurances that ‘US banking is safe.’ Major US banks were also affected by the crash as fear spread throughout the market, with Wells Fargo plummeting 7.5 percent, Bank of America falling 7.4 percent, Citigroup plunging 5.8 percent and JP Morgan down 2.7 percent. US President Joe Biden insisted that the system was safe after...

President Trump took a common sense approach to reinvigorating the American public education system on Monday in Davenport, Iowa, making a big promise that drew thunderous applause from thousands of supporters in the audience.“I will immediately sign a new EO to cut federal funding for any school that’s pushing critical race theory, transgender insanity and any other racial, sexual or political content on our children – THEY’RE CHILDREN,” he said.He also stated that he would “bring back parental rights into our school system,” hitting on an incredibly popular campaign policy that American parents have responded positively to since its introduction...