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Keyword: spla2iia

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  • Like venom coursing through the body: Researchers identify mechanism driving COVID-19 mortality (possible solution)

    08/27/2021 7:01:31 AM PDT · by ConservativeMind · 23 replies
    An enzyme with an elusive role in severe inflammation may be a key mechanism driving COVID-19 severity and could provide a new therapeutic target to reduce COVID-19 mortality, according to a study published in the Journal of Clinical Investigation. sPLA2-IIA, which has similarities to an active enzyme in rattlesnake venom, is found in low concentrations in healthy individuals and has long been known to play a critical role in defense against bacterial infections, destroying microbial cell membranes. When the activated enzyme circulates at high levels, it has the capacity to "shred" the membranes of vital organs, said Floyd (Ski) Chilton....
  • Scientists may have discovered the most important indicator of dying from COVID-19

    08/25/2021 12:48:45 PM PDT · by RummyChick · 34 replies
    express ^ | 8/25/2021 | SOLEN LE NET
    ...Researchers believe the secretion of the sPLA2-IIA enzyme in COVID-19 patients could be the most important predictor of death in patients. sPLA2-IIA, which has similarities to an active enzyme in rattlesnake venom, is found in low concentrations in healthy individuals and has long been known to play a critical role in defence against bacterial infections. However, when the enzyme circulates at high levels, it has the capacity to shred the body’s vital organs, according to Floyd Chilton, senior author on the paper. Doctor Chilton said: “It’s a bell-shaped curve of disease resistance versus host tolerance.....