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Like venom coursing through the body: Researchers identify mechanism driving COVID-19 mortality (possible solution)
Science Daily / University of Arizona ^ | Aug. 23, 2021

Posted on 08/27/2021 7:01:31 AM PDT by ConservativeMind

An enzyme with an elusive role in severe inflammation may be a key mechanism driving COVID-19 severity and could provide a new therapeutic target to reduce COVID-19 mortality, according to a study published in the Journal of Clinical Investigation.

sPLA2-IIA, which has similarities to an active enzyme in rattlesnake venom, is found in low concentrations in healthy individuals and has long been known to play a critical role in defense against bacterial infections, destroying microbial cell membranes.

When the activated enzyme circulates at high levels, it has the capacity to "shred" the membranes of vital organs, said Floyd (Ski) Chilton.

"In this study, we were able to identify patterns of metabolites that were present in individuals who succumbed to the disease," said lead study author Justin Snider, an assistant research professor in the UArizona Department of Nutrition. "The metabolites that surfaced revealed cell energy dysfunction and high levels of the sPLA2-IIA enzyme. The former was expected but not the latter."

Using the same machine learning methods, the researchers developed a decision tree to predict COVID-19 mortality. Most healthy individuals have circulating levels of the sPLA2-IIA enzyme hovering around half a nanogram per milliliter. According to the study, COVID-19 was lethal in 63% of patients who had severe COVID-19 and levels of sPLA2-IIA equal to or greater than 10 nanograms per milliliter.

"Many patients who died from COVID-19 had some of the highest levels of this enzyme that have ever been reported," said Chilton, who has been studying the enzyme for over three decades.

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Health/Medicine
KEYWORDS: covid19; enzyme; floydchilton; inflammation; kungflu; organs; spla2iia; venom
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Interestingly, I found a 13 year old paper that identified an over the counter block for sPLA2-IIA. I’ll put it in the next post.
1 posted on 08/27/2021 7:01:31 AM PDT by ConservativeMind
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To: ConservativeMind

This is the study that found the substance:

https://www.jstage.jst.go.jp/article/bpb/31/4/31_4_714/_article

This expensive item on Amazon has the substance:

https://www.amazon.com/Fucoidan-YOHO-MEKABU-FUCOIDAN/dp/B00DB7CP1Q


2 posted on 08/27/2021 7:02:49 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Bkmrk


3 posted on 08/27/2021 7:03:38 AM PDT by RushIsMyTeddyBear (RIP my "teddy bear". )
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To: ConservativeMind
MeFucoidan is another name for “mekabu fucoidan,” which comes from

“the sporophyll (Mekabu) of brown seaweed Undaria pinnatifida (wakame)”

https://pubmed.ncbi.nlm.nih.gov/25037398/

4 posted on 08/27/2021 7:05:48 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Apply the Blood to your doorposts and this angel of death will pass you by.


5 posted on 08/27/2021 7:08:14 AM PDT by fwdude (If you don’t think you are in a battle w/ the culture for your children then you are already losing.)
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To: ConservativeMind

Wakame seaweed is a common form of seaweed:

https://draxe.com/nutrition/wakame/


6 posted on 08/27/2021 7:08:15 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Yes, it’s very expensive. But at least it is sourced/manufactured in Japan so you can be sure of its quality unlike much of the crap that comes from China and India.


7 posted on 08/27/2021 7:10:29 AM PDT by House Atreides
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To: ConservativeMind

Isn’t sPLA2-IIA found in much higher concentrations in the clinically obese...?


8 posted on 08/27/2021 7:13:20 AM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: ConservativeMind

Bite a rattle snake


9 posted on 08/27/2021 7:13:38 AM PDT by Pollard (#*&% Communism)
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To: ConservativeMind
In other COVID seaweed news…
Iota-carrageenan from red seaweed inhibits SARS-CoV-2 in laboratory conditions
Dr. Tomislav Meštrović, MD, Ph.D.
Jul 29 2020

In a recent bioRxiv paper, a research group from the Marinomed Biotech biopharmaceutical company in Austria showed that a sulfated polysaccharide iota-carrageenan has the propensity to inhibit cell entry of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by using an in vitro neutralization assay.


10 posted on 08/27/2021 7:16:34 AM PDT by ProtectOurFreedom (“Criminal democrats kill babies. Do you think anything else is a problem for them?”)
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To: ConservativeMind

bookmark


11 posted on 08/27/2021 7:18:49 AM PDT by GOP Poet (Super cool you can change your tag line EVERYTIME you post!! :D. (Small things make me happy))
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To: ConservativeMind

Bkmk


12 posted on 08/27/2021 7:19:35 AM PDT by moovova (Joe Biden...Making the Taliban great again!...")
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To: ConservativeMind

how about rattlesnake anti-venom?


13 posted on 08/27/2021 7:22:51 AM PDT by rolling_stone
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To: ProtectOurFreedom

Yes, I’ve made four nasal spray bottle of that for myself and my wife.


14 posted on 08/27/2021 7:24:21 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Ivermectin and HCQ and Zinc!

Don;t give the enzyme long enough to build up/


15 posted on 08/27/2021 8:03:10 AM PDT by GraceG ("If I post an AWESOME MEME, STEAL IT! JUST RE-POST IT IN TWO PLACES PLEASE")
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To: ConservativeMind
a natural substance that inhibits the sPLA2-IIA is maslinic acid, aka triterpene. NIH: Inhibition of Human Group IIA-Secreted Phospholipase A2 and THP-1 Monocyte Recruitment by Maslinic Acid

Didn't find anything searching for maslinic acid, but found triterpene in several products on Amazon. Looks like Goto Kola extracts and Reishi Mushroom extracts, may be the strongest.

No clue how much to take.

I'm guessing you would only take this once diagnosed or sick.

16 posted on 08/27/2021 8:10:34 AM PDT by DannyTN
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To: GraceG

Book Mark


17 posted on 08/27/2021 8:18:31 AM PDT by Rumplemeyer (The GOP should stand its ground - and fix Bayonets)
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To: ConservativeMind

https://www.encyclopedia.com/social-sciences-and-law/law/crime-and-law-enforcement/biological-weapons

“For example, the former Soviet Union experimented with the instillation of the gene responsible for the production of cobra toxin into normally harmless bacteria that reside in the intestinal tract.”


18 posted on 08/27/2021 8:40:26 AM PDT by BenLurkin (The above is not a statement of fact. It is either opinion, or satire. Or both.)
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To: ConservativeMind

Thanks for finding this!


19 posted on 08/27/2021 11:08:29 AM PDT by WildHighlander57 ((WildHighlander57 returning after lurking since 2000) )
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To: ConservativeMind

There’s rattlers in the talus below the nearby cliffs. I’m gonna go get me bit.


20 posted on 08/27/2021 11:12:13 AM PDT by Sirius Lee (They intend to murder us. Prep if you want to live and live like you are prepping for eternal life)
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