It is a riddle that has confounded scholars for over a century. And now it carries a handsome cash prize: $1 million for anyone who can decipher the script of the ancient Indus Valley civilization. Relatively little is known about the creators of the script, who built a sprawling urban system about 5,000 years ago across what is modern-day India, Pakistan and Afghanistan. Excavations at more than 2,000 sites have unearthed a wealth of artifacts. But until the civilization’s script can be read, its language, culture and religion, as well as the history of its rise and fall, will remain...