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Patients with ovarian cancer are 70% less likely to die three years after a multidisciplinary surgical approach is deployed, according to new research. The study on treating advanced ovarian cancer has found that aggressive surgery involving multiple specialists has a significant impact on survival rates. The work analyzed more than 300 patients separated into two cohorts treated between 2006 and 2015 and 2017 to 2021. In 2017, the Department of Gynecological Oncology at the Mater adopted an innovative approach to ovarian cancer surgery that saw collaboration between different surgical disciplines to perform operations focused on removing all visible tumors from...

Tennis legend Chris Evert has opened up about how her younger sister's devastating death from ovarian cancer helped to 'save her life', revealing how her sibling's battle with the disease prompted her to undergo testing - allowing her own cancer to be detected incredibly early. The 67-year-old offered a candid glimpse into her cancer battle for an upcoming episode of HBO's Real Sports, with GMA airing a preview clip on Monday morning - in which Evert is seen undergoing her final rounds of chemo, while paying tribute to her late sister Jeanne Evert Dubin. 'My sister's death saved my life,'...

Ovarian cancer has one of the highest death rates of all cancers. One reason for this is that the cancer turns the body's defenses against itself. However, new research suggests that vitamin D can effectively prevent one of the key pathways used by this cancer. Ovarian cancer often undergoes a process called peritoneal metastasis. In this process, its cells detach from their primary site in the ovary and travel to a secondary implantation site, such as the peritoneal wall or diaphragm. The peritoneum defends against this process using a barrier consisting of mesothelial cells, which prevent the adhesion of cancer...

Abstract Relevance: Ivermectin, as an old anti-parasite drug, can suppress almost completely the growth of various human cancers, including ovarian cancer (OC). However, its anticancer mechanism remained to be further studied at the molecular levels. Ivermectin-related molecule-panel changes will serve a useful tool for its personalized drug therapy and prognostic assessment in OCs. Purpose: To explore the functional significance of ivermectin-mediated lncRNA-EIF4A3-mRNA axes in OCs and ivermectin-related molecule-panel for its personalized drug therapy monitoring. Methods: Based on our previous study, a total of 16 lncRNA expression patterns were analyzed using qRT-PCR before and after ivermectin-treated different OC cell lines (TOV-21G...

SYDNEY (AFP) - Australian scientists have discovered pineapple molecules can act as powerful anti-cancer agents and said the research could lead to a new class of cancer-fighting drugs. Scientists at the Queensland Institute of Medical Research (QIMR) said their work centred on two molecules from bromelaine, an extract derived from crushed pineapple stems that is used to tenderise meat, clarify beers and tan hides. One of the molecules, CCZ, stimulates the body's immune system to target and kill cancer cells, the other, CCS, blocks a protein called Ras, which is defective in 30 percent of all cancers. QIMR researcher Tracey...

“I don’t like that full feeling when I’m running, so I don’t drink that much.” For Judy Williams, a 56-year-old single mom from Riverview, Florida, this statement doesn’t hold true anymore, at least not after a life altering hospital visit in 2015 after she ran the Gasparilla Distance Classic. Williams has been racing in the Classic since 1989, and she loves doing all four challenges: the 5K, 8K, 15K, and half marathon over the course of two days. She even ran while pregnant with her two daughters, Kelly, 19, and Abby, 18. The Classic is the race Williams looks forward...

A California judge on Friday threw out a $417 million verdict against Johnson & Johnson in a lawsuit by a woman who claimed she developed ovarian cancer after using its talc-based products like Johnson’s Baby Powder for feminine hygiene. The ruling by Los Angeles Superior Court Judge Maren Nelson marked the latest setback facing women and family members who accuse J&J of not adequately warning consumers about the cancer risks of its talc-based products. The decision followed a jury’s decision in August to hit J&J with the largest verdict to date in the litigation, awarding California resident Eva Echeverria $70...

Two years after she underwent a double mastectomy to cut her cancer risk, actress and U.N. envoy Angelina Jolie has had surgery to remove her ovaries and fallopian tubes for the same reason, she wrote in The New York Times on Tuesday. Jolie, 39, carries a mutation of the BRCA1 gene, which sharply increases her risk of developing breast cancer and ovarian cancer. Her mother was diagnosed with the latter at age 49 and died seven years later. In her New York Times op-ed Tuesday, Jolie said she had been planning the latest preventive surgery for some time.

Abstract Here, we propose a new strategy for the treatment of early cancerous lesions and advanced metastatic disease, via the selective targeting of cancer stem cells (CSCs), a.k.a., tumor-initiating cells (TICs). We searched for a global phenotypic characteristic that was highly conserved among cancer stem cells, across multiple tumor types, to provide a mutation-independent approach to cancer therapy. This would allow us to target cancer stem cells, effectively treating cancer as a single disease of “stemness”, independently of the tumor tissue type. Using this approach, we identified a conserved phenotypic weak point – a strict dependence on mitochondrial biogenesis for...

October is the pink month for the NFL. Players, coaches, cheerleaders and even stadiums are adorned with the color to promote Breast Cancer Awareness Month. The league also sells pink merchandise (hats, jerseys, etc.) and donates a portion of the proceeds to the American Cancer Society. How much of the proceeds? Well, not a whole lot. ESPN’s Darren Rovell is reporting (via Business Insider) that the league takes a “25 percent royalty from the wholesale price (1/2 retail), donates 90 percent of royalty to American Cancer Society.”

Using blood and tissue samples donated by patients, the University of Pennsylvania’s Working Dog Center has started training three canines to sniff out the signature compound that indicates the presence of ovarian cancer. If the animals can isolate the chemical marker, scientists at the nearby Monell Chemical Senses Center will work to create an electronic sensor to identify the same odorant. “Because if the dogs can do it, then the question is, Can our analytical instrumentation do it? We think we can,” Monell organic chemist George Preti said.

Actor Pierce Brosnan is devastated after his daughter Charlotte died, aged just 42. The mother-of-two died after a three year battle with ovarian cancer - the same disease which killed her mother Cassandra 22 years ago - at her London home on Friday. Pierce, who has been filming a spy thriller, November Man, in Eastern Europe, last night said: ‘On June 28 my darling daughter Charlotte Emily passed on to eternal life, having succumbed to ovarian cancer. She was surrounded by her husband Alex, children Isabella and Lucas and brothers Christopher and Sean.

The Lancet, Early Online Publication, 8 December 2011 doi:10.1016/S0140-6736(11)61746-7Cite or Link Using DOI The plight of nuns: hazards of nulliparity Original TextKara Britt a, Roger Short b Catholic nuns are committed to leading a celibate, spiritual life in a monastery or convent. In 1713, Italian physician Bernadino Ramazzini1 noted that nuns had an extremely high incidence of that "accursed pest", breast cancer. Today, the world's 94,790 nuns still pay a terrible price for their chastity because they have a greatly increased risk of breast, ovarian, and uterine cancers: the hazards of their nulliparity. Fraumeni and colleagues2 compiled data for...

Two independent groups working with advanced-stage cases say the drug extended the period before the disease worsened by more than 3.5 months. Avastin can stabilize tumors in women suffering from advanced-stage ovarian cancer, extending the period before the disease worsens by more than 3.5 months, according to the results of two large, international clinical trials conducted by separate research teams. The findings, published in Thursday's edition of the New England Journal of Medicine, come less than a week after the European Commission approved Avastin for treating women newly diagnosed with advanced ovarian cancer. The drug, known generically as bevacizumab, has...

Bedford-based company that makes drugs to treat cancer is under scrutiny ... ...Ben Venue Laboratories Inc. announced on Nov. 19 that it had shut down production, a move that exacerbated an already serious shortage of a critical drug to treat ovarian cancer. The company does not know when it will resume production of the drug Doxil, but is working on correcting the problems as quickly as possible, Boehringer Ingelheim Corp. spokesman Jason Kurtz, said Thursday in an email. Boehringer Ingelheim owns Ben Venue. Kurtz said the company was not prepared to address specific questions at this time, but will make...

Researchers from the University and the Mayo Clinic in Arizona have developed a vaccine that dramatically reduces tumors in a mouse model that mimics 90 percent of human breast and pancreatic cancer cases—including those resistant to common treatments. The vaccine, described this week in the early edition of the journal Proceedings of the National Academy of Sciences, reveals a promising new strategy for treating cancers that share the same distinct carbohydrate signature, including ovarian and colorectal cancers.

I need to ask for you guys to put someone in your thoughts and prayers. Someone I work with at a site, a young black woman with 2 little boys under 4 was diagnosed with skin cancer when she was pregnant with the second boy last year. Because she's so dark, the skin changes had gone undetected for years, and they got worse when she got pregnant the second time. Even the Drs were baffled with her skin problems at first, and she got lots of wrong diagnosis' and treatment, up until about a month before the baby was born...

Cancer experts have identified a set of health problems that may be symptoms of ovarian cancer, and they are urging women who have the symptoms for more than a few weeks to see their doctors. The new advice is the first official recognition that ovarian cancer, long believed to give no warning until it was far advanced, does cause symptoms at earlier stages in many women. The symptoms to watch out for are bloating, pelvic or abdominal pain, difficulty eating or feeling full quickly and feeling a frequent or urgent need to urinate. A woman who has any of those...

Eleven million people around the world - 23,000 of them Israeli - will have been diagnosed with cancer by the end of 2006, according to Prof. Peter Boyle, head of the World Health Organization's International Agency for Cancer Research (IACR) based in Lyon, France. But Israeli researchers, "who are among the best in the world," are helping to increase the survival rates of more patients, he said, pointing to an experimental device originally developed in the Israeli defense industry that has the potential to provide earlier and better diagnoses. The Histocan, which includes a tiny air-driven camera, is being tested...

Last year, members of the Alliance for Nanotechnology in Cancer based at Northeastern University and the Massachusetts Institute of Technology demonstrated that acid-sensitive polymer nanoparticles could boost the delivery of anticancer drugs into the acidic interior of tumors. Now, that same group of investigators has shown that these nanoparticles are effective at suppressing tumor growth when tested in an animal model of human ovarian cancer. In addition, animals treated with this nanoparticle formulation do not appear to experience adverse side effects that often limit the ability of patients to tolerate chemotherapy. The researchers reported the results of their preclinical work...