Boosting the level of a brain chemical reverses learning impairments in a mouse model of Down syndrome, researchers report. The work adds to emerging evidence that cognition-enhancing drugs may one day help humans with Down syndrome lead more independent lives. Down syndrome is the most common cause of mental retardation, affecting approximately one in 800 babies at birth. People with the disorder have an extra copy of chromosome 21, giving them additional copies of hundreds of genes. This somehow alters brain development and causes mild to severe learning disabilities. To investigate what goes wrong in the brain of someone who...