When older adults living in nursing homes are prescribed the pain medicine tramadol alongside certain antidepressants, their risk of seizures may go up, according to a study. While this study found a link, it does not prove one causes the other. Tramadol is an opioid used to treat moderate to severe pain in adults. Some antidepressants that inhibit the CYP2D6 enzyme, called CYP2D6 inhibitors, can interfere with how the body metabolizes tramadol. When the CYP2D6 enzyme is blocked, tramadol is not metabolized properly and may build up in the body, potentially increasing the risk of side effects like seizures. Common...