Free Republic

The International Osteoporosis Foundation (IOF) Bone and Cancer Working Group has released a comprehensive review detailing the often under-recognized impact of modern anti-cancer treatments on bone health. It highlights the need to address cancer treatment-induced bone loss (CTIBL), including in patients undergoing cutting-edge therapies. The publication provides a review of the bone effects of major anti-cancer therapies currently in use, including newer agents, and discusses their known cellular impacts, effects on bone mineral density (BMD), and fracture incidence by drug category. Among the key messages: —Drugs such as glucocorticoids, hormone therapies, antiangiogenic drugs, and immune checkpoint inhibitors show varying degrees...

Young stem cells (left) produce more material (dark brown) for bone than old stem cells (center), and a new study shows how they can be rejuvenated by adding sodium acetate (right)Pouikli/Max Planck Institute for Biology of Ageing VIEW 1 IMAGES ____________________________________________________________________________________ Scientists looking into the biological mechanisms behind deteriorating bones have made a discovery that could help tackle age-related conditions like osteoporosis, by rejuvenating stem cells that are central to the process. The newly published study demonstrates how certain changes compromise the performance of these stem cells as they age, but also shows how sodium acetate can be used to...