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Researchers have discovered early signs of clinical benefit while testing niraparib, a PARP inhibitor, in patients with advanced melanoma whose tumors had specific genetic changes impacting DNA repair. The single-arm, investigator-initiated phase II trial examined the effectiveness of niraparib in a select group of patients whose disease previously progressed after standard treatment such as immunotherapy, and BRAF/MEK-targeted therapies. The U.S. FDA approved tumor-infiltrating lymphocyte therapy for advanced melanoma in patients who have previously received anti-programmed cell death 1 (PD-1) antibody therapy, and if their tumors are V600 BRAF-mutant, a combination of BRAF and MEK inhibitors. "Despite these available, approved combination...

In a study, researchers explore a surprising phenomenon in which high doses of radiation cause growth in existing metastatic tumors that weren't directly treated with radiation. Scientists had previously observed that radiation can cause distant tumors to shrink after radiation, known as the "abscopal effect." The researchers dubbed the opposite response the "badscopal effect." They believe this unexpected response happens because high-dose radiation increases the production of a protein called amphiregulin by tumor cells that are directly treated with radiation. High amounts of amphiregulin weaken the immune system's ability to fight cancer and make cancer cells better at protecting themselves....

@realAtlasPress Though Britain had been a global power since the early 17th century, it wasn’t until Napoleon's defeat at Waterloo in 1815 that it emerged as the dominant power. By eliminating France from the world’s stage, Britain was left without a serious competitor. The Vienna Treaty that followed favored the Brits, granting them territorial possessions like modern-day South Africa, Trinidad, and Sri Lanka. These territories served as strategic naval bases Britain used to control its immense empire from all corners of the globe. The century following Napoleon's defeat is sometimes called the “Pax Britannica,” because of the relative prosperity enjoyed...

One of the illegal migrants accused of raping and killing little Jocelyn Nungaray and dumping her body in a Houston bayou allegedly raped another victim before the youngster’s vicious slaying, the former district attorney revealed — as she expressed concerns with her successor’s lax prosecution style. During Democrat Kim Ogg’s investigation into the 12-year-old’s barbaric murder a year ago, a woman came forward claiming that Franklin Jose Pena Ramos sexually assaulted her while she was vacationing in Costa Rica, the former DA told Fox 26 Houston Thursday. Ogg has known about the rape allegation since late last year as she...

New research has revealed that regular, moderate-intensity exercise helps maintain crucial vitamin D levels during the darker months—even without weight loss or supplements. Researchers found that people with overweight and obesity who completed a 10‑week indoor exercise program over winter experienced significantly smaller drops in vitamin D levels compared to those who didn't exercise—even though their body weight was deliberately maintained. The program involved four sessions per week: two treadmill walks, one longer steady‑state bike ride, and one high‑intensity interval bike session. Notably, exercise completely preserved the body's active form of vitamin D (1,25(OH)₂D₃), which plays a key role in...

Microsoft founder Bill Gates says that most of his fortune will be spent on improving health and education services in Africa over the next 20 years. The 69-year-old said that "by unleashing human potential through health and education, every country in Africa should be on a path to prosperity". Speaking in Ethiopia's capital Addis Ababa, he also urged Africa's young innovators to think about how to build Artificial Intelligence (AI) to improve healthcare on the continent. Gates announced last month that he would give away 99% of his vast fortune - which he expects to reach $200bn (£150bn) - by...

Why do @ICEgov agents wear masks? ICE Director Todd Lyons emotional…saying his agents are being doxxed, harassed, and sent death threats. People even threatening the agents children.

In Boulder, Colorado, eight elderly Jews were torched alive in a park. They wore red T-shirts bearing the names of hostages seized by Palestinian terrorists over 600 days earlier. Some carried Israeli flags. Walking peacefully in memory and solidarity, they were attacked with fire as a flamethrower and Molotov cocktails created flames as high as a tree. An 88-year-old Holocaust survivor was among the injured. The attacker, Mohamed Sabry Soliman, is reported to be an Egyptian national in the country illegally. He now faces murder charges. This third such targeted attack on American Jews in three months confirms a disturbing...

It was the easiest thing in the world to predict: The media’s moment of half-hearted contrition for “missing” President Joe Biden’s obvious physical and cognitive decline has given way already to a fixation on President Trump’s health. The journalists have no choice, you see. They’re humbled now. Their renewed zeal for the truth compels them to correct for the reporting mistakes of the Biden era. Therefore, they must now be unrelentingly suspicious of Trump’s mental and physical health. They learned their lesson! The mea culpas seem awfully hollow now — more like a thin cover for a public relations reset,...

Female police officer suffers broken ankle and nose in Phoenix.

The GDPNow model estimate for real GDP growth (seasonally adjusted annual rate) in the second quarter of 2025 is 4.6 percent on June 2, up from 3.8 percent on May 30. After this morning’s releases from the US Census Bureau and the Institute for Supply Management, the nowcasts of second-quarter real personal consumption expenditures growth and real gross private domestic investment growth increased from 3.3 percent and -1.4 percent, respectively, to 4.0 percent and 0.5 percent.

"OMG even California Democrats are GHOSTING their representatives. This guy is preaching about going after Trump to a dozen people. NOBODY likes the Democrats anymore." GuntherEagleman X (Video)

Tucker Carlson said he's not sure he can support the Republican party after a Florida congressman called for Gaza to be nuked. Congressman Randy Fine, who was recently elected to replace Mike Waltz in Florida as the preferred candidate of President Trump, made the jaw dropping comments in a Fox News interview last month. He said: 'In World War 2 we did not negotiate a surrender with the Nazis, we did not negotiate a surrender with the Japanese. 'We nuked the Japanese twice in order to get unconditional surrender. That needs to be the same here in Gaza. 'There is...

Sowell's top 10 worst US presidents.I think he's nailed to top five. 1. bammy 2. LBJ 3. FDR 4. Wilson 5. Carter

Progressive California Rep. Maxine Waters' campaign has agreed to pay a $68,000 fine after an investigation found it violated multiple election rules.The Federal Election Commission (FEC) said the longtime House lawmaker's 2020 campaign committee, Citizens for Waters, ran afoul of several campaign finance laws in a tranche of documents released Friday.The FEC accused Citizens for Waters of "failing to accurately report receipts and disbursements in calendar year 2020," "knowingly accepting excessive contributions" and "making prohibited cash disbursements," according to one document that appears to be a legally binding agreement that allows both parties to avoid going to court.

https://nsarchive.gwu.edu/briefing-book/russia-programs/2017-12-12/nato-expansion-what-gorbachev-heard-western-leaders-early Declassified documents show security assurances against NATO expansion to Soviet leaders from Baker, Bush, Genscher, Kohl, Gates, Mitterrand, Thatcher, Hurd, Major, and Woerner U.S. Secretary of State James Baker’s famous “not one inch eastward” assurance about NATO expansion in his meeting with Soviet leader Mikhail Gorbachev on February 9, 1990, was part of a cascade of assurances about Soviet security given by Western leaders to Gorbachev and other Soviet officials throughout the process of German unification in 1990 and on into 1991, according to declassified U.S., Soviet, German, British and French documents posted today by the National Security Archive...

Paperwork with the word "USAID" was found in the car of Mohamed Sabry Soliman, who's accused of allegedly throwing explosives at a group in Boulder, Colorado, peacefully protesting for the release of Hamas' hostages. The incident happened on Sunday as the pro-Israel group "Run for Their Lives" was protesting on Pearl Street. Boulder police said eight people were injured in the alleged terror attack, adding that they initially received reports of a man setting people on fire. According to an arrest affidavit, law enforcement officials found paperwork with the words "USAID" inside Soliman's 2015 silver Toyota Prius. Other paperwork with...

Google is launching AI Mode, a new AI-powered search feature for US-based users. After a short testing period in its Labs environment, the feature will be rolling out for everyone in the coming weeks via a new Search tab and the Google app. The company describes AI Mode as its “most powerful AI search, with more advanced reasoning and multimodality, and the ability to go deeper through follow-up questions and helpful links to the web.” New features of AI Mode include Deep Search with longer-than-usual, report-style responses, Search Live, which enables users to talk with Search about what they see...

Girls given antibiotics during their first year of life, especially in the first three months, are more likely to enter puberty at an earlier age, according to research. The likelihood of early puberty was also higher among those exposed to a greater variety of antibiotic classes. The findings highlight the importance of using these medicines in infants appropriately and how early-life drug exposure could shape future health outcomes. Early puberty, also known as central precocious puberty (CPP), is a condition characterized by the early onset of secondary sexual development in children. In girls this means before age 8 and, in...

Unfortunately, Raskin was not arguing that people really need to learn to use their guns against terrorists more quickly and with deadly accuracy, which is the lesson that any normal human being would have to stop crazed Islamist terrorists from setting Jews on fire. Instead, he really went on television to argue that the attack in Colorado, in which an enraged Islamist attacked Jewish protesters, is a prime example of why we need more gun restrictions and stricter background checks for gun purchasers.